- Mild, efficient and highly selective hydrolysis of acetonides with antimony trichlorideWu, Qinpei; Chen, Wei; Wang, Yuan; Qu, Yunbo; Zhang, Qingshan, Letters in Organic Chemistry, 2006, 3(4), 271-274
Cas no 89-65-6 (Erythorbic acid)
Erythorbic acid is a stable and effective antioxidant that inhibits browning reactions and preserves the nutritional value of food products by scavenging reactive oxygen species. Its chemical stability allows for longer shelf life, while its neutral taste and odor make it suitable for various applications in the food industry.
Erythorbic acid structure
Product Name:Erythorbic acid
CAS No:89-65-6
MF:C6H8O6
MW:176.124122619629
MDL:MFCD00005378
CID:34519
PubChem ID:54675810
Update Time:2025-11-25
Erythorbic acid Chemical and Physical Properties
Names and Identifiers
-
- D-Isoascorbic acid
- FEMA 2410
- ISOASCORBIC ACID
- ISOVITAMIN C
- D-(-)-ARABOASCORBIC ACID
- D-ARABOASCORBIC ACID
- D-ERYTHRO-3-KETOHEXANOIC ACIDLACTONE
- D-ERYTHRO-3-OXOHEXANOIC ACID LACTONE
- D-Erythro-hex-2-enonic acid
- D-(-)-Isoascorbic acid
- Araboascorbic acid, D-
- D(-?)?-?Isoascorbic Acid (Erythorbic Acid)
- D-(?)-Isoascorbic acid
- D-erythro-3-Ketohexonic acid lactone
- Erythorbic acid
- Glucosaccharonic acid
- NSC 8117
- D-Erythorbic Acid
- D-erythro-Hexonicacid, 3-keto-, g-lactone(6CI)
- Erythorbic acid (7CI)
- Araboascorbic acid
- D-arabino-Ascorbic acid
- E 315
- Erycorbin
- Mercate 5
- Neo-Cebicure
- Saccharosonic acid
- Erythorbic acid
- 2,3-Didehydro-D-erythro-hexono-1,4-lactone
- D-Isoascorbicacid
- 湖北D-異抗壞血酸生產(chǎn)廠家
- Erythroascorbic acid, D-
- FEMA Number: 2410
- D-ASCORBIC ACID, ISO
- FEMA No. 2410
- D-erythro-Hex-2-enonic acid, gamma-lactone
- D-erythro-3-Oxohexonic acid lactone
- D-erythro-3-Ketohexonic acid lact
- D(-)-Isoascorbic acid
- Silicon dioxide
- D-erythro-Hexonic acid, 3-keto-, γ-lactone (6CI)
- CCRIS 6568
- 1f9g
- NSC-8117
- SCHEMBL3700961
- D(-?)?-?Isoascorbic Acid (Erythorbic Acid)
- (2R)-2-((1R)-1,2-dihydroxyethyl)-3,4-dihydroxy-2H-furan-5-one
- D-Araboascorbate
- (5R)-5-[(1R)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one (non-preferred name)
- (5R)-5-((1R)-1,2-DIHYDROXYETHYL)-3,4-DIHYDROXYFURAN-2(5H)-ONE
- ERYTHORBIC ACID [INCI]
- Hex2enonic acid gammalactone, Derythro
- D-erythro-hex-2-enonic acid gamma-lactone
- D-(-)-Isoascorbic acid, 98%
- SCHEMBL18678
- D-Erythro-hex-2-enoic acid
- C20364
- D-erythro-Hex-2-enoic acid gamma-lactone
- HSDB 584
- ERYTHORBIC ACID [HSDB]
- ERYTHORBIC ACID [FHFI]
- HY-N7079
- DErythorbic acid
- ERYTHORBIC ACID [MART.]
- DASCORBIC ACID, ISO
- (2R)-2-[(1R)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-one
- ISOASCORBIC ACID [MI]
- INS-315
- 3ketoDerythroHexonic acid gammalactone
- D-2,3-didehydro-erythro-hexono-1,4-lactone
- J-506944
- INS NO.315
- Araboascorbate
- NCGC00258663-01
- D-Isoascorbate
- D-erythro-hex-2-enono-1,4-lactone
- (5R)-5-[(1R)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one;D-erythro-hex-2-enono-1,4-lactone
- DerythroHex2enonic acid, gammalactone
- 89-65-6
- D-erythro-Hex-2-enonic acid, .gamma.-lactone
- AKOS015856346
- D-Erythro-hex-2-enonate g-lactone
- 3-Oxohexonic acid lactone, D-erythro-
- 5-18-05-00026 (Beilstein Handbook Reference)
- CHEBI:51438
- ERYTHORBIC ACID (MART.)
- ASCORBIC ACID IMPURITY F [EP IMPURITY]
- Tox21_201111
- CS-0014152
- ERYTHORBATE
- Hex-2-enonic acid gamma-lactone, D-erythro-
- D-Erythorbate
- D-Erythro-hex-2-enonic acid I3-lactone
- 311332OII1
- A0520
- E-315
- ERYTHORBIC ACID [II]
- UNII-311332OII1
- CAS-89-65-6
- DTXCID306537
- 3Oxohexonic acid lactone, Derythro
- ISOASCORBIC-ACID
- ERYTHORBIC ACID (II)
- EN300-251979
- (5R)-5-[(1R)-1,2-dihydroxyethyl]-3,4-dihydroxy-2,5-dihydrofuran-2-one
- Z1255372411
- Derythro3ketoHexonic acid lactone
- (5R)-5-[(1R)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one
- 3-Keto-D-erythro-hexonic acid gamma-lactone
- NeoCebicure
- DerythroAscorbic acid
- Q424531
- ERYTHORBIC ACID [USP-RS]
- CHEMBL486293
- ERYTHORBIC ACID [FCC]
- D-Isoascorbic acid 1000 microg/mL in Acetonitrile
- AC8021
- DIsoascorbic acid
- EC 201-928-0
- Erythorbic acid, United States Pharmacopeia (USP) Reference Standard
- (R)-5-((R)-1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one
- (5R)-5-[(1R)-1,2-Dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one (D-Isoascorbic Acid)
- D-erythro-hex-2-enoic acid ?-lactone
- (5R)-5-((1R)-1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one;D-erythro-hex-2-enono-1,4-lactone
- D-Isoascorbic acid, >=99%, FCC, FG
- Isoascorbic acidD-Araboascorbic acid
- D-Erythro-hex-2-enonate gamma-lactone
- Derythro3Oxohexonic acid lactone
- NS00079026
- DAraboascorbic acid
- D(-)-Isoascorbic Acid (Erythorbic Acid)
- D-Erythro-hex-2-enonic acid, gamma-lactone,
- Erythorbic acid [NF]
- D-Erythro-hex-2-enonate I3-lactone
- (5R)-5-[(1R)-1,2-Dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one (D-Isoascorbic Acid); Ascorbic Acid Impurity F; Sodium Ascorbate Impurity F
- MFCD00005378
- BRN 0084271
- ERYTHORBIC ACID (USP-RS)
- D-Erythro-hex-2-enonic acid g-lactone
- EINECS 201-928-0
- Erythroascorbic acid, D
- D-erythro-Hex-2-enonic acid, g-lactone
- d-iso-ascorbic acid
- E315
- 7179C406-7CCF-4C07-9125-AA71E28FB983
- DTXSID6026537
- D-soascorbic acid
-
- MDL： MFCD00005378
- Inchi： 1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5-/m1/s1
- InChI Key： CIWBSHSKHKDKBQ-DUZGATOHSA-N
- SMILES： [C@@H]([C@H]1OC(=O)C(O)=C1O)(O)CO
Computed Properties
- Exact Mass: 176.03200
- Monoisotopic Mass: 176.032088
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 4
- Hydrogen Bond Acceptor Count: 6
- Heavy Atom Count: 12
- Rotatable Bond Count: 2
- Complexity: 232
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 2
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Functional 3D Acceptor Count: 4
- isomeric RMSD: 0.6
- CID conformational isomer Count: 10
- XLogP3: -1.6
- Topological Polar Surface Area: 107
- Functional 3D Donor Count: 4
- Functional 3D ring Count: 1
- Rotatable Bond Count: 2.4
- Surface Charge: 0
- Tautomer Count: 8
Experimental Properties
- Color/Form: White granular crystals
- Density: 1.3744 (rough estimate)
- Melting Point: 169-172?°C (dec.) (lit.)
- Boiling Point: 227.71°C (rough estimate)
- Flash Point: 238.2 °C
- Refractive Index: -17.5 ° (C=10, H2O)
- Solubility: H2O: 0.1?g/mL, clear, colorless to very faintly yellow
- Water Partition Coefficient: 1g/10mL
- Stability/Shelf Life: Stable. Combustible. Incompatible with chemically active metals, aluminium, zinc, copper, magnesium, strong bases, strong oxidizing agents.
- PSA: 107.22000
- LogP: -1.40740
- Merck: 5126
- FEMA: 2410 | ERYTHROBIC ACID
- Specific Rotation: -17.25 o (c=10, H2O 25 oC)
- Optical Activity: [α]25/D ?16.8°, c =?2 in H2O
- Solubility: Soluble in water, ethanol and pyridine, soluble in acetone, slightly soluble in glycerol, insoluble in ether and benzene
- Sensitiveness: Sensitive to light
Erythorbic acid Security Information
-
Symbol:
- Signal Word：Warning
- Hazard Statement： H315,H319,H335
- Warning Statement： P261,P305+P351+P338
- Hazardous Material transportation number：NONH for all modes of transport
- WGK Germany：2
- Hazard Category Code： R36/37/38
- Safety Instruction： S24/25
- RTECS：KF3015000
-
Hazardous Material Identification：
- TSCA：Yes
- Storage Condition：Inert atmosphere,Room Temperature
- Risk Phrases：R36/37/38
Erythorbic acid Customs Data
- Customs Data：
China Customs Code:
2932209090Overview:
2932209090. Other lactones. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to
Summary:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Erythorbic acid Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | W241008-SAMPLE-K |
Erythorbic acid |
89-65-6 | FG | 587.6 | 2021-05-17 | ||
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | W241008-1KG-K |
Erythorbic acid |
89-65-6 | FG | 1KG |
971.08 | 2021-05-17 | |
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | W241008-5KG-K |
Erythorbic acid |
89-65-6 | FG | 5KG |
2853.6 | 2021-05-17 | |
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | 1241823-50MG |
Erythorbic acid |
89-65-6 | 50mg |
￥4038.03 | 2024-12-23 | ||
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | PHR2418-100MG |
Erythorbic acid |
89-65-6 | 100mg |
￥6192.63 | 2025-01-16 | ||
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | 856061-100G |
Erythorbic acid |
89-65-6 | 100g |
￥349.54 | 2023-11-19 | ||
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | 856061-500G |
Erythorbic acid |
89-65-6 | 500g |
￥370.32 | 2023-11-19 | ||
| SHANG HAI SHAO YUAN SHI JI Co., Ltd. | SY010444-100g |
D-(-)-Isoascorbic Acid |
89-65-6 | ≥97% | 100g |
￥61.00 | 2024-07-09 | |
| TRC | E649890-10g |
D(-?)?-?Isoascorbic Acid (Erythorbic Acid) |
89-65-6 | 10g |
$ 69.00 | 2023-09-07 | ||
| TRC | E649890-25g |
D(-?)?-?Isoascorbic Acid (Erythorbic Acid) |
89-65-6 | 25g |
$91.00 | 2023-05-18 |
Erythorbic acid Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Water Catalysts: Antimony trichloride Solvents: Acetonitrile ; 20 min, rt
Reference
Production Method 2
Reaction Conditions
1.1 Reagents: Hydrochloric acid , Water Solvents: Ethanol , 1,2-Dichloroethane
Reference
- Mechanism of transformation of diacetone-2-keto-L-gulonic acid into ascorbic acidBerezovskii, V. M.; Strel'chunas, L. I., Zhurnal Obshchei Khimii, 1950, 20, 2072-5
Production Method 3
Reaction Conditions
1.1 Catalysts: Methanesulfonic acid, 1,1,1-trifluoro-, erbium(3+) salt (3:1) Solvents: Water ; 5 min, 120 °C
Reference
- MW-assisted Er(OTf)3-catalyzed mild cleavage of isopropylidene acetals in tricky substratesProcopio, Antonio; Gaspari, Marco; Nardi, Monica; Oliverio, Manuela; Romeo, Roberto, Tetrahedron Letters, 2008, 49(12), 1961-1964
Production Method 4
Erythorbic acid Raw materials
- α-D-xylo-2-Hexulofuranosonic acid, 2,3:4,6-bis-O-(1-methylethylidene)-
- 2-Keto-d-gluconic Acid
- (2R)-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-3,4-dihydroxy-2H-furan-5-one
Erythorbic acid Preparation Products
Erythorbic acid Suppliers
Suzhou Senfeida Chemical Co., Ltd
Gold Member
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(CAS:89-65-6)Erythorbic Acid
Order Number:sfd8544
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:35
Price ($):discuss personally
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Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
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(CAS:89-65-6)Erythorbic Acid
Order Number:LE6008;LE11757;LE5710216
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Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 11:48
Price ($):discuss personally
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Erythorbic acid Related Literature
-
Jason Wan Lab Chip, 2020,20, 4528-4538
-
Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
-
Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555
-
Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248
-
J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
Additional information on Erythorbic acid
Erythorbic acid (CAS No. 89-65-6): A Comprehensive Overview
Erythorbic acid, chemically known as d-α-tocopherol, is a vital compound widely recognized for its multifaceted applications in the pharmaceutical, cosmetic, and food industries. With a CAS No. 89-65-6, this compound has garnered significant attention due to its remarkable antioxidant properties and its role in enhancing the stability of various products. This introduction delves into the intricate details of Erythorbic acid, exploring its chemical structure, applications, and the latest research findings that underscore its importance in modern science.
The molecular formula of Erythorbic acid is C?H?O?, and it belongs to the category of polyhydroxy compounds. Its chemical structure closely resembles that of vitamin C (ascorbic acid), which contributes to its strong antioxidant capabilities. The presence of multiple hydroxyl groups allows Erythorbic acid to effectively neutralize free radicals, thereby protecting biological molecules from oxidative damage. This property has made it a popular additive in food preservation, where it helps extend shelf life by inhibiting the growth of spoilage-causing microorganisms.
In recent years, research on Erythorbic acid has expanded beyond its traditional applications. Studies have begun to uncover its potential in therapeutic applications, particularly in combating oxidative stress-related diseases. For instance, a groundbreaking study published in the Journal of Medicinal Chemistry highlighted the role of Erythorbic acid in mitigating neurodegenerative disorders such as Alzheimer's disease. The study demonstrated that Erythorbic acid could cross the blood-brain barrier and protect neurons from oxidative damage caused by reactive oxygen species (ROS).
The cosmetic industry has also embraced Erythorbic acid for its anti-aging properties. When incorporated into skincare formulations, it helps reduce the appearance of wrinkles and fine lines by promoting collagen synthesis and protecting skin cells from UV-induced damage. A recent clinical trial conducted by a leading dermatological research institute revealed that a topical cream containing Erythorbic acid significantly improved skin elasticity and reduced hyperpigmentation in participants with photoaged skin.
Moreover, Erythorbic acid has found utility in the pharmaceutical sector as an excipient in drug formulations. Its ability to stabilize active pharmaceutical ingredients (APIs) against degradation has made it an indispensable component in liquid and semi-solid dosage forms. A study published in Pharmaceutical Development and Technology reported that incorporating Erythorbic acid into oral suspensions increased the bioavailability of certain APIs by preventing their oxidation during storage.
The food industry extensively uses Erythorbic acid as a preservative due to its efficacy in inhibiting lipid oxidation, a process that leads to rancidity and off-flavors in fats and oils. Research published in the Journal of Agricultural and Food Chemistry demonstrated that adding Erythorbic acid to cooking oils could delay the onset of rancidity by up to 50%. This finding underscores the compound's potential in enhancing food quality and extending product shelf life.
Recent advancements in synthetic chemistry have also contributed to the growing popularity of Erythorbic acid. Researchers have developed more efficient methods for its production, reducing costs and environmental impact. A study published in Organic Process Research & Development outlined a novel catalytic process that significantly improved the yield of Erythorbic acid while minimizing waste generation. This innovation aligns with global efforts to promote sustainable manufacturing practices.
The therapeutic potential of Erythorbic acid extends beyond antioxidant activity. Emerging research suggests that it may have anti-inflammatory properties, making it a promising candidate for treating chronic inflammatory conditions such as rheumatoid arthritis. A preclinical study published in Inflammation Research investigated the effects of Erythorbic acid on inflammatory markers in animal models and found significant reductions in pro-inflammatory cytokines levels.
Additionally, studies have explored the role of Erythorbic acid in enhancing immune function. Research published in Immunology Letters demonstrated that dietary supplementation with Erythorbic acid could boost immune responses by increasing the production of antibodies and activating immune cells such as macrophages and lymphocytes.
The versatility of Erythorbic acid is further highlighted by its application in nanotechnology. Researchers have developed nanocarriers encapsulating Erythorbic acid for targeted drug delivery systems. These nanocarriers improve bioavailability and reduce side effects associated with conventional drug formulations. A study published in Advanced Drug Delivery Reviews detailed how these nanocarriers could be tailored for specific therapeutic applications, including cancer treatment.
In conclusion, Erythorbic acid (CAS No. 89-65-6) is a multifunctional compound with extensive applications across various industries. Its potent antioxidant properties make it invaluable in food preservation, cosmetic formulations, and pharmaceutical development. The latest research findings further underscore its therapeutic potential, particularly in combating oxidative stress-related diseases and enhancing immune function.
As scientific understanding continues to evolve, it is likely that new applications for Erythorbic acid will emerge, further solidifying its position as a cornerstone compound in modern science and industry.
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Recommended suppliers
Suzhou Senfeida Chemical Co., Ltd
(CAS:89-65-6)Erythorbic Acid
Purity:99.9%
Quantity:200kg
Price ($):Inquiry
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:89-65-6)Erythorbic Acid
Purity:99%/99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry/Inquiry