Production Method 1

2402-77-9

889865-45-6

Reaction Conditions

1.1 Reagents: Butyllithium ,  2,2,6,6-Tetramethylpiperidine Solvents: Diethyl ether ,  Hexane ;  -78 °C; 10 min, -78 °C
1.2 Solvents: Tetrahydrofuran ;  -78 °C; 30 min, -78 °C
1.3 Reagents: Iodine Solvents: Tetrahydrofuran ;  -78 °C; overnight, -78 °C → rt
1.4 Reagents: Sodium thiosulfate Solvents: Water

Reference

Regiocontrolled microwave assisted bifunctionalization of 7,8-dihalogenated Imidazo[1,2-α]pyridines: a one pot double-coupling approach

Marie, Emilie; Boucle, Sebastien; Enguehard-Gueiffier, Cecile; Gueiffier, Alain, Molecules, 2012, 17, 10683-10707

Production Method 2

2402-77-9

889865-45-6

Reaction Conditions

1.1 Reagents: Butyllithium ,  2,2,6,6-Tetramethylpiperidine Solvents: Diethyl ether ,  Hexane ;  -78 °C; 10 min, -78 °C
1.2 Solvents: Tetrahydrofuran ;  -78 °C; 45 min, -78 °C
1.3 Reagents: Iodine Solvents: Tetrahydrofuran ;  -78 °C → rt; 16 h, rt
1.4 Reagents: Sodium thiosulfate Solvents: Water

Reference

Imidazo[1,2-a]pyridines: Orally Active Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor

Trabanco, Andres A.; Tresadern, Gary; Macdonald, Gregor J.; Vega, Juan Antonio; de Lucas, Ana Isabel; et al, Journal of Medicinal Chemistry, 2012, 55(6), 2688-2701

Production Method 3

2402-77-9

889865-45-6

Reaction Conditions

1.1 Reagents: Butyllithium ,  2,2,6,6-Tetramethylpiperidine ,  Dichloro(N,N,N′,N′-tetramethylethylenediamine)zinc Solvents: Tetrahydrofuran ,  Hexane ;  15 min, 0 °C
1.2 2 h, rt
1.3 Reagents: Iodine Solvents: Tetrahydrofuran ;  overnight, rt

Reference

Deprotonative Metalation of Chloro- and Bromopyridines Using Amido-Based Bimetallic Species and Regioselectivity-Computed CH Acidity Relationships

Snegaroff, Katia; Nguyen, Tan Tai; Marquise, Nada; Halauko, Yury S.; Harford, Philip J.; et al, Chemistry - A European Journal, 2011, 17(47), 13284-13297

Production Method 4

2402-77-9

889865-45-6

Reaction Conditions

1.1 Reagents: Piperidine, 2,2,6,6-tetramethyl-, lithium salt (1:1) Solvents: Tetrahydrofuran ,  Hexane ;  -78 °C; 30 min, -78 °C
1.2 Reagents: Iodine Solvents: Tetrahydrofuran ;  1 h, -78 °C → rt
1.3 Reagents: Sodium thiosulfate Solvents: Water ;  rt

Reference

Synthesis and evaluation of the anticoccidial activity of trifluoropyrido[1,2-a]pyrimidin-2-one derivatives

Silpa, Laurence; Niepceron, Alisson; Laurent, Fabrice; Brossier, Fabien; Penichon, Melanie; et al, Bioorganic & Medicinal Chemistry Letters, 2016, 26(1), 114-120

2,3-Dichloro-4-iodopyridine Raw materials

• 2,3-Dichloropyridine

2,3-Dichloro-4-iodopyridine Preparation Products

• 2,3-Dichloro-4-iodopyridine (889865-45-6)

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• 30332-35-5(Pyridine,2,3,5,6-tetrachloro-4-iodo-)
• 796851-03-1(2,5-Dichloro-4-iodopyridine)
• 406676-23-1(2,3,5-Trichloro-4-iodopyridine)
• 97966-01-3(2,3-Dichloro-5-iodopyridine)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)