Production Method 1

13939-06-5

88982-82-5

88982-82-5

Reaction Conditions

1.1 Solvents: Acetonitrile ,  Water ;  overnight, pH 9.5, rt
1.2 Reagents: Ethanol
1.3 Reagents: Cesium hydroxide Catalysts: Palladate(1-), [2′-(amino-κN)[1,1′-biphenyl]-2-yl-κC]chloro[2′-(dicyclohexylphos… Solvents: 1-Methoxy-2-propanol ,  Water ;  15 h, 80 °C

Reference

Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis

Li, Jian-Yuan; Miklossy, Gabriella; Modukuri, Ram K.; Bohren, Kurt M.; Yu, Zhifeng; et al, Bioconjugate Chemistry, 2019, 30(8), 2209-2215

Production Method 2

959755-96-5

88982-82-5

Reaction Conditions

1.1 Reagents: Lithium hydroxide Solvents: Methanol ;  1 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 1, rt

Reference

Synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as mGluR5 (metabotropic glutamate receptor 5) antagonists

Vu, Hoang Nam; Kim, Ji Young; Hassan, Ahmed H. E.; Choi, Kihang; Park, Jong-Hyun; et al, Bioorganic & Medicinal Chemistry Letters, 2016, 26(1), 140-144

Production Method 3

4175-77-3

88982-82-5

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Diethyl ether
1.2 Reagents: Carbon dioxide

Reference

Fluorinations with sulfur tetrafluoride and hydrogen fluoride. 2. Preparation of trifluoromethylated thiazoles and isothiazoles

Nickson, Thomas E., Journal of Fluorine Chemistry, 1991, 55(2), 173-7

Production Method 4

167366-05-4

88982-82-5

Reaction Conditions

1.1 Reagents: 2-Methyl-2-butene ,  Monosodium phosphate ,  Sodium chlorite Solvents: tert-Butanol ,  Water ;  rt; 12 h, rt
1.2 Reagents: Sodium chloride Solvents: Water ;  rt

Reference

Discovery, Structure-Activity Relationship, and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP

Wu, Fangrui; Hua, Yuanda; Kaochar, Salma; Nie, Shenyou; Lin, Yi-Lun; et al, Journal of Medicinal Chemistry, 2020, 63(9), 4716-4731

4-Bromo-1,3-thiazole-2-carboxylic acid Raw materials

• Hexacarbonylmolybdenum
• 2,4-Dibromothiazole
• 4-Bromo-1,3-thiazole-2-carboxylic acid
• 4-bromo-1,3-thiazole-2-carbaldehyde
• ethyl 4-bromo-1,3-thiazole-2-carboxylate

4-Bromo-1,3-thiazole-2-carboxylic acid Preparation Products

• 4-Bromo-1,3-thiazole-2-carboxylic acid (88982-82-5)

• 1. Aggregation of biologically important peptides and proteins: inhibition or acceleration depending on protein and metal ion concentrations
  Benjamin Gabriel Poulson,Kacper Szczepski,Joanna Izabela Lachowicz,Lukasz Jaremko,Abdul-Hamid Emwas,Mariusz Jaremko RSC Adv., 2020,10, 215-227
• 2. An investigation of surface properties, local elastic modulus and interaction with simulated pulmonary surfactant of surface modified inhalable voriconazole dry powders using atomic force microscopy
  Michael Kappl,Paul M. Young,Daniela Traini,Sanyog Jain RSC Adv., 2016,6, 25789-25798
• 3. Aggregation, pretransitional behavior, and optical properties in the isotropic phase of lyotropic chromonic liquid crystals studied in high magnetic fields
  Tanya Ostapenko,Peter J. Collings,Samuel N. Sprunt,J. T. Gleeson Soft Matter, 2013,9, 9487-9498
• 4. Aggregation-induced chiroptical generation and photoinduced switching of achiral azobenzene-alt-fluorene copolymer endowed with left- and right-handed helical polysilanes?
  Hailing Chen,Lu Yin,Meng Liu,Laibing Wang,Michiya Fujiki,Wei Zhang RSC Adv., 2019,9, 4849-4856
• 5. An insight into the origin of room-temperature ferromagnetism in SnO2 and Mn-doped SnO2 quantum dots: an experimental and DFT approach?
  Dhamodaran Manikandan,S. Amirthapandian,I. S. Zhidkov,A. I. Kukharenko,S. O. Cholakh,Ramaswamy Murugan Phys. Chem. Chem. Phys., 2018,20, 6500-6514

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Thiazolecarboxylic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Thiazoles Thiazolecarboxylic acids and derivatives

• 2172596-90-4(sodium 4-bromo-1,3-thiazole-2-carboxylate)
• 167366-05-4(4-bromo-1,3-thiazole-2-carbaldehyde)
• 1540130-95-7(4-Bromo-5-methyl-1,3-thiazole-2-carboxylic acid)
• 959755-96-5(ethyl 4-bromo-1,3-thiazole-2-carboxylate)
• 1806352-39-5(4,5-Dibromothiazole-2-carboxylic acid)
• 1025468-06-7(methyl 4-bromo-1,3-thiazole-2-carboxylate)
• 204513-31-5((4-bromo-1,3-thiazol-2-yl)methanol)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)