Cas no 888719-03-7 (BMS-2)

BMS-2 structure
BMS-2 structure
Product Name:BMS-2
CAS No:888719-03-7
MF:C25H16F2N4O3
MW:458.416352272034
MDL:MFCD16619360
CID:69353
PubChem ID:21081761
Update Time:2024-10-26

BMS-2 Chemical and Physical Properties

Names and Identifiers

    • 1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide
    • Bms-2
    • BMS-2 MET KINASE INHIBITOR
    • N-(4-((1H-Pyrrolo[2,3-b]pyridin-4-yl)oxy)-3-fluorophenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
    • MET kinase-IN-4
    • 1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide (ACI)
    • 1-(4-Fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxopyridine-3-carboxamide
    • BMS 2
    • CHEMBL509101
    • 888719-03-7
    • Q27095800
    • NS00071621
    • CS-0007413
    • BCPP000329
    • DTXSID50610618
    • N-(3-fluoro-4-{1H-pyrrolo[2,3-b]pyridin-4-yloxy}phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
    • N-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
    • 3ce3
    • 1-(4-Fluorophenyl)-N-{3-fluoro-4-[(1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl}-2-oxo-1,2-dihydropyridine-3-carboxamide
    • TS-09790
    • N-(3-fluoro-4-{1H-pyrrolo[2,3-b]pyridin-4-yloxy}phenyl)-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide
    • CID 21081761
    • GLXC-15828
    • NCGC00345824-02
    • SCHEMBL4817260
    • NCGC00345824-01
    • 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide
    • BDBM24440
    • 1FN
    • BCP9000423
    • SYN-1022
    • AKOS027323284
    • HY-18309
    • MFCD16619360
    • DB06896
    • JMC521251 Compound 1
    • BMS-2
    • MDL： MFCD16619360
    • Inchi： 1S/C25H16F2N4O3/c26-15-3-6-17(7-4-15)31-13-1-2-19(25(31)33)24(32)30-16-5-8-22(20(27)14-16)34-21-10-12-29-23-18(21)9-11-28-23/h1-14H,(H,28,29)(H,30,32)
    • InChI Key： OBSFXHDOLBYWRJ-UHFFFAOYSA-N
    • SMILES： O=C(C1C(=O)N(C2C=CC(F)=CC=2)C=CC=1)NC1C=C(F)C(OC2C3=C(NC=C3)N=CC=2)=CC=1

Computed Properties

  • Exact Mass: 458.11904671g/mol
  • Monoisotopic Mass: 458.11904671g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 7
  • Heavy Atom Count: 34
  • Rotatable Bond Count: 6
  • Complexity: 829
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 4.1
  • Topological Polar Surface Area: 87.3?2

Experimental Properties

  • Density: 1.41
  • Melting Point: 212-214℃
  • Boiling Point: 701.5 °C at 760 mmHg
  • Flash Point: 378.1 °C

BMS-2 Security Information

BMS-2 Pricemore >>

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N-(4-((1H-Pyrrolo[2,3-b]pyridin-4-yl)oxy)-3-fluorophenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide, 97%
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BMS-2 Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Diisopropylethylamine ,  O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate Solvents: Dimethylformamide ,  Acetonitrile ;  0 °C; 0 °C → rt; 2 h, rt; 3 h, rt
1.2 Reagents: Sodium hydroxide Solvents: Water ;  30 min, rt
Reference
Discovery of Pyrrolopyridine-Pyridone Based Inhibitors of Met Kinase: Synthesis, X-ray Crystallographic Analysis, and Biological Activities
Kim, Kyoung Soon; Zhang, Liping; Schmidt, Robert; Cai, Zhen-Wei; Wei, Donna; et al, Journal of Medicinal Chemistry, 2008, 51(17), 5330-5341

BMS-2 Raw materials

BMS-2 Preparation Products

BMS-2 Suppliers

Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:888719-03-7)BMS-2
Order Number:A900063
Stock Status:in Stock
Quantity:100g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 12:04
Price ($):1435.0

BMS-2 Related Literature

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Recommended suppliers
Amadis Chemical Company Limited
(CAS:888719-03-7)BMS-2
A900063
Purity:99%
Quantity:100g
Price ($):1435.0
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