• 1. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 2. An integrated microfluidic 3D tumor system for parallel and high-throughput chemotherapy evaluation?
  Dan Liu,Rui Hu,Zhongchao Huang,Meilin Sun,Kai Han Analyst, 2020,145, 6447-6455
• 3. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
• 4. An amorphous Cu–In–S nanoparticle-based precursor ink with improved atom economy for CuInSe2 solar cells with 10.85% efficiency?
  Green Chem., 2017,19, 1268-1277
• 5. An ion-gating multinanochannel system based on a copper-responsive self-cleaving DNAzyme?
  Yang Chen,Di Zhou,Zheyi Meng,Jin Zhai Chem. Commun., 2016,52, 10020-10023

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines

Piperidine, 1-(6-bromohexyl)-, hydrobromide (CAS No. 88805-98-5): A Comprehensive Overview

Piperidine, 1-(6-bromohexyl)-, hydrobromide, identified by its CAS number 88805-98-5, is a significant compound in the realm of pharmaceutical chemistry and medicinal research. This compound belongs to the piperidine class of heterocyclic amines, characterized by a six-membered ring containing one nitrogen atom. The presence of a bromo-substituted hexyl side chain and a hydrobromide salt form enhances its utility in synthetic chemistry and drug development.

The< strong> bromo group in the molecular structure of Piperidine, 1-(6-bromohexyl)-, hydrobromide serves as a versatile handle for further functionalization. This feature makes it a valuable intermediate in the synthesis of more complex molecules, particularly in the development of novel therapeutic agents. The< strong> hydrobromide salt form improves the compound's solubility in water, facilitating its use in various biochemical assays and pharmaceutical formulations.

In recent years, there has been growing interest in< strong>piperidine derivatives due to their broad spectrum of biological activities. The< strong>1-(6-bromohexyl)piperidine moiety has been explored in several pharmacological contexts, including the development of central nervous system (CNS) drugs, antiviral agents, and anti-inflammatory compounds. Its structural motif is often incorporated into drug candidates to enhance binding affinity and metabolic stability.

One of the most compelling aspects of< strong>Piperidine, 1-(6-bromohexyl)-, hydrobromide is its role in medicinal chemistry as a building block for more intricate molecules. Researchers have leveraged its< strong>bromo substituent to introduce diverse functional groups through cross-coupling reactions such as Suzuki-Miyaura and Buchwald-Hartwig couplings. These reactions enable the construction of biaryl structures and other complex scaffolds that are prevalent in modern drug designs.

The< strong>hydrobromide salt form of this compound also contributes to its practicality in laboratory settings. It provides a stable crystalline form that is easy to handle and store, ensuring consistent quality for research applications. Furthermore, its improved solubility allows for efficient dissolution in solvents commonly used in high-throughput screening (HTS) and other biochemical assays.

Recent studies have highlighted the potential of< strong>piperidine derivatives, including< strong>Piperidine, 1-(6-bromohexyl)-, hydrobromide, in addressing unmet medical needs. For instance, researchers have investigated its efficacy as a precursor in the synthesis of kinase inhibitors, which are crucial for treating cancers and inflammatory diseases. The< strong>bromo group's reactivity allows for precise modifications that can fine-tune the pharmacokinetic properties of these inhibitors.

The development of CNS drugs has also benefited from< strong>piperidine-based compounds. The structural features of< strong>Piperidine, 1-(6-bromohexyl)-, hydrobromide, particularly the piperidine ring and the< strong>6-bromohexyl side chain, contribute to favorable pharmacokinetic profiles. These characteristics make it an attractive scaffold for designing ligands that interact with neurotransmitter receptors involved in mood regulation and cognitive function.

In addition to its applications in small-molecule drug discovery, Piperidine, 1-(6-bromohexyl)-, hydrobromide has found utility in biopharmaceutical research. Its ability to serve as a precursor for more complex molecules has been exploited in the synthesis of monoclonal antibodies and other biologic drugs. The< strong>bromo-substituted piperidine core can be incorporated into antibody-drug conjugates (ADCs), enhancing their therapeutic efficacy.

The compound's versatility extends to its role as an intermediate in peptide and protein modification studies. Researchers have utilized< strong>Piperidine, 1-(6-bromohexyl)-, hydrobromide to introduce fluorophores or other functional groups into biomolecules for imaging and diagnostic applications. Its compatibility with various synthetic methodologies makes it a valuable tool in proteomics and structural biology.

The future prospects of< strong>Piperidine, 1-(6-bromohexyl)-, hydrobromide are promising, given its broad utility across multiple domains of pharmaceutical research. As synthetic chemistry advances, new methodologies will likely emerge that further expand its applications. The continued exploration of piperidine derivatives will undoubtedly lead to innovative therapeutic solutions addressing diverse medical conditions.

• 74509-66-3(1-Hexanamine,6-bromo-N,N-diethyl-)
• 104304-09-8(1-Pentanaminium, 5-bromo-N,N,N-triethyl-, bromide)
• 596810-52-5(Piperidine, 4-(4-bromobutyl)-1-methyl-)
• 90733-28-1(6-Bromo-N,N-dipropylhexan-1-amine)
• 15008-33-0(5-Bromopentyltrimethylammonium Bromide)
• 58689-34-2(1-(3-Bromopropyl)piperidine hydrobromide)
• 61272-70-6(1-(3-bromopropyl)piperidine)
• 76150-19-1(1-Decanamine, 10-bromo-N,N-dimethyl-, hydrobromide)
• 161097-76-3(6-BROMOHEXYLTRIETHYLAMMONIUM BROMIDE)
• 1159174-36-3(1-BROMO-7-(TRIMETHYLAMMONIUM)HEPTYL BROMIDE)