Production Method 1

29509-06-6

88786-11-2

Reaction Conditions

1.1 Reagents: Sodium acetate ,  Hydroxyamine hydrochloride Solvents: Methanol ;  1 h, rt
1.2 overnight, rt
1.3 Solvents: Water ;  rt

Reference

An enantioselective aza-Friedel-Crafts reaction of 5-aminoisoxazoles with isatin-derived N-Boc ketimines

Liu, Hui; Yan, Yingkun; Li, Min; Zhang, Xiaomei, Organic & Biomolecular Chemistry, 2021, 19(17), 3820-3824

Production Method 2

29509-06-6

88786-11-2

Reaction Conditions

1.1 Reagents: Sodium hydroxide ,  Hydroxylamine, sulfate Solvents: Ethanol ,  Water ;  pH 7.5, rt; 15 h, 80 °C

Reference

Identification of 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Hydrochloride (CEP-32496), a Highly Potent and Orally Efficacious Inhibitor of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) V600E

Rowbottom, Martin W.; Faraoni, Raffaella; Chao, Qi; Campbell, Brian T.; Lai, Andiliy G.; et al, Journal of Medicinal Chemistry, 2012, 55(3), 1082-1105

Production Method 3

29509-06-6

88786-11-2

Reaction Conditions

1.1 Reagents: Sodium hydroxide ,  Hydroxylamine, sulfate Solvents: Water ;  pH 8 - 11, rt; 1.5 h, rt → 100 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  15 min, 100 °C; cooled
1.3 Reagents: Sodium hydroxide Solvents: Water ;  pH 11

Reference

A reliable synthesis of 3-amino-5-alkyl and 5-amino-3-alkyl isoxazoles

Johnson, Leland; Powers, James; Ma, Fupeng; Jendza, Keith; Wang, Bing; et al, Synthesis, 2013, 45(2), 171-173

3-(propan-2-yl)-1,2-oxazol-5-amine Raw materials

• 4-Methyl-3-oxopentanenitrile

3-(propan-2-yl)-1,2-oxazol-5-amine Preparation Products

• 3-(propan-2-yl)-1,2-oxazol-5-amine (88786-11-2)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Isoxazoles

• 344746-40-3(3-(pentan-3-yl)-1,2-oxazol-5-amine)
• 59669-59-9(3-Tert-Butylisoxazol-5-amine)
• 1012879-79-6(3-(1-Methylcyclopentyl)-1,2-oxazol-5-amine)
• 59669-75-9(3-t-Butyl-5-methylaminoisoxazole)
• 344353-06-6(3-(sec-Butyl)-5-isoxazolamine)
• 344752-36-9(5-Isoxazolamine,3-(1,2,2-trimethylpropyl)-(9CI))
• 82560-06-3(5-Isoxazolamine,3-(1-ethyl-1-methylpropyl)-)
• 77479-49-3(3-Ethylisoxazol-5-amine)
• 21080-91-1(3-cyclopropyl-1,2-oxazol-5-amine)
• 500766-46-1(3-cyclohexyl-1,2-oxazol-5-amine)