Production Method 1

100523-84-0

88770-19-8

Reaction Conditions

1.1 Reagents: p-Toluenesulfonic acid Solvents: Methanol ;  12 h, reflux

Reference

Carboxylate-Substituted Polythiophenes for Efficient Fullerene-Free Polymer Solar Cells: The Effect of Chlorination on Their Properties

Wang, Qi; Li, Miaomiao; Zhang, Xiaowei; Qin, Yunpeng; Wang, Junke; et al, Macromolecules (Washington, 2019, 52(12), 4464-4474

Production Method 2

100523-84-0

88770-19-8

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  30 min, 80 °C; 80 °C → rt
1.2 rt; 60 min, 80 °C

Reference

Thermal behavior of dicarboxylic ester bithiophene polymers exhibiting a high open-circuit voltage

Heuvel, Ruurd; Colberts, Fallon J. M.; Wienk, Martijn M.; Janssen, Rene A. J., Journal of Materials Chemistry C: Materials for Optical and Electronic Devices, 2018, 6(14), 3731-3742

Production Method 3

100523-84-0

88770-19-8

Reaction Conditions

1.1 Solvents: Diethyl ether

Reference

Synthesis and Solid-State Structures of Dimethyl 2,2'-Bithiophenedicarboxylates

Pomerantz, Martin; Amarasekara, Ananda S.; Dias, H. V. Rasika, Journal of Organic Chemistry, 2002, 67(20), 6931-6937

Production Method 4

100523-84-0

88770-19-8

Reaction Conditions

1.1 Reagents: Lithium hydroxide Solvents: Tetrahydrofuran ;  30 min, rt
1.2 2 h, reflux

Reference

Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors

Wallace-Povirk, Adrianne; Tong, Nian; Wong-Roushar, Jennifer; O'Connor, Carrie; Zhou, Xilin; et al, Bioorganic & Medicinal Chemistry, 2021, 37,

Production Method 5

100523-84-0

88770-19-8

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  reflux

Reference

Macrocycles with bithiophene units: synthesis, structure, and electrochemical properties

Demeter, Dora; Lar, Claudia; Roncali, Jean; Grosu, Ion, Tetrahedron Letters, 2013, 54(11), 1460-1462

Methyl 5-bromothiophene-3-carboxylate Raw materials

• 5-Bromothiophene-3-carboxylic acid

Methyl 5-bromothiophene-3-carboxylate Preparation Products

• Methyl 5-bromothiophene-3-carboxylate (88770-19-8)

• 1. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
  Sowmyalakshmi Venkataraman RSC Adv., 2015,5, 73807-73813
• 2. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 3. Emerging investigator series: first-principles and thermodynamics comparison of compositionally-tuned delafossites: cation release from the (001) surface of complex metal oxides?
  Joseph W. Bennett,Diamond T. Jones,Blake G. Hudson,Joshua Melendez-Rivera,Robert J. Hamers,Sara E. Mason Environ. Sci.: Nano, 2020,7, 1642-1651
• 4. Excited state potential energy surfaces and their interactions in FeIVO active sites
  Shaun D. Wong,Edward I. Solomon Dalton Trans., 2014,43, 17567-17577
• 5. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Thiophenes Thiophene carboxylic acids and derivatives

• 289470-44-6(Ethyl 2,5-dibromothiophene-3-carboxylate)
• 100523-84-0(5-Bromothiophene-3-carboxylic acid)
• 7311-70-8(2,5-Dibromothiophene-3-carboxylic acid)
• 76360-43-5(Methyl 2-bromothiophene-3-carboxylate)
• 24287-95-4(2-Bromothiophene-3-carboxylic acid)
• 89280-91-1(Methyl 2,5-dibromothiophene-3-carboxylate)
• 170355-38-1(Ethyl 5-bromothiophene-3-carboxylate)
• 1259396-11-6(Methyl 5-bromo-2-methylthiophene-3-carboxylate)
• 1015423-45-6(4,6-Dibromothieno3,4-cfuran-1,3-dione)
• 632325-50-9(Ethyl 2-bromothiophene-3-carboxylate)