Production Method 1

261762-35-0

887584-98-7

Reaction Conditions

1.1 Reagents: Magnesium ,  Iodine Solvents: Diethyl ether ;  2 h, reflux
1.2 Solvents: Tetrahydrofuran ;  1 h, 10 °C
1.3 Reagents: Hydrochloric acid Solvents: Water

Reference

Development of potential preclinical candidates with promising in vitro ADME profile for the inhibition of type 1 and type 2 17β-Hydroxysteroid dehydrogenases: Design, synthesis, and biological evaluation

Abdelsamie, Ahmed S. ; Salah, Mohamed; Siebenbuerger, Lorenz; Hamed, Mostafa M.; Boerger, Carsten; et al, European Journal of Medicinal Chemistry, 2019, 178, 93-107

3,4-Difluoro-5-methoxybenzoic acid Raw materials

• 5-Bromo-2,3-difluoroanisole

3,4-Difluoro-5-methoxybenzoic acid Preparation Products

• 3,4-Difluoro-5-methoxybenzoic acid (887584-98-7)

• 1. Excitation dependent bidirectional electron transfer in phthalocyanine-functionalised MoS2 nanosheets?
  Christopher J. Harrison,Kyle J. Berean,Enrico Della Gaspera,Jian Zhen Ou,Richard B. Kaner,Kourosh Kalantar-zadeh,Torben Daeneke Nanoscale, 2016,8, 16276-16283
• 2. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
  Sowmyalakshmi Venkataraman RSC Adv., 2015,5, 73807-73813
• 3. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 4. Excellent humidity sensor based on ultrathin HKUST-1 nanosheets?
  Qiaoe Wang,Meiling Lian,Xiaowen Zhu,Xu Chen RSC Adv., 2021,11, 192-197
• 5. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Methoxybenzoic acids and derivatives

• 319-60-8(3,5-Difluoro-4-methoxybenzoic acid)
• 82846-18-2(4-Fluoro-3-methoxybenzoic acid)
• 5710-64-5(4-ethoxy-3-fluorobenzoic acid)
• 918629-69-3(Benzoic acid, 3-fluoro-4-(4-fluorophenoxy)-)
• 403-20-3(3-Fluoro-4-methoxybenzoic acid)
• 1261927-20-1(3-(3-Fluoro-4-hydroxyphenyl)-5-methoxybenzoic acid)
• 1195945-01-7(3-fluoro-5-hydroxy-4-methoxybenzoic acid)
• 1785030-01-4(4-Fluoro-3,5-dimethoxybenzoic Acid)
• 77279-89-1(4-Fluoro-3-phenoxybenzoic Acid)
• 749230-45-3(3,4-Difluoro-5-hydroxybenzoic acid)