Production Method 1

1016163-41-9

887572-60-3

Reaction Conditions

1.1 Reagents: Lithium hydroxide Solvents: Tetrahydrofuran ,  Water ;  4 h, 160 °C

Reference

Synthesis and in vitro opioid receptor functional antagonism of analogues of the selective kappa opioid receptor antagonist (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic)

Cai, Tingwei Bill; Zou, Zhou; Thomas, James B.; Brieaddy, Larry; Navarro, Hernan A.; et al, Journal of Medicinal Chemistry, 2008, 51(6), 1849-1860

Production Method 2

20033-99-2

887572-60-3

Reaction Conditions

1.1 Reagents: Permanganic acid (HMnO4), potassium salt (1:1)

Reference

Synthesis and evaluation of selected benzimidazole derivatives as potential antimicrobial agents

Alasmary, Fatmah A. S.; Snelling, Anna M.; Zain, Mohammed E.; Alafeefy, Ahmed M.; Awaad, Amani S.; et al, Molecules, 2015, 20(8), 15206-15223

Production Method 3

20033-99-2

887572-60-3

Reaction Conditions

1.1 Reagents: Sodium carbonate Solvents: Water ;  reflux; heated
1.2 Reagents: Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Water ;  1 h, heated; cooled
1.3 Reagents: Acetic acid Solvents: Water ;  neutralized

Reference

Synthesis and anti-inflammatory activity of some benzimidazole-2-carboxylic acids

Thakurdesai, Prasad A.; Wadodkar, Sudhir G.; Chopade, Chandrabhan T., Pharmacologyonline, 2007, (1), 314-329

5-methoxy-1H-1,3-benzodiazole-2-carboxylic acid Raw materials

• 6-methoxy-1H-Benzimidazole-2-carboxylic acid methyl ester
• (5-methoxy-1H-benzimidazol-2-yl)methanol

5-methoxy-1H-1,3-benzodiazole-2-carboxylic acid Preparation Products

• 5-methoxy-1H-1,3-benzodiazole-2-carboxylic acid (887572-60-3)

• 1. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
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• 4. Fe3O4 nanosphere@microporous organic networks: enhanced anode performances in lithium ion batteries through carbonization?
  Byungho Lim,Jaewon Jin,Jin Yoo,Seung Yong Han,Kyeongyeol Kim,Sungah Kang,Nojin Park,Sang Moon Lee,Hae Jin Kim,Seung Uk Son Chem. Commun., 2014,50, 7723-7726
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• 2849-93-6(1H-1,3-benzodiazole-2-carboxylic acid)
• 1000875-28-4(6-ethoxy-1H-Benzimidazole-2-carboxylic acid)
• 1016163-41-9(6-methoxy-1H-Benzimidazole-2-carboxylic acid methyl ester)
• 20033-99-2((5-methoxy-1H-benzimidazol-2-yl)methanol)
• 889961-14-2((5-ethoxy-1H-1,3-benzodiazol-2-yl)methanol)
• 420137-33-3(5-hydroxy-1H-1,3-benzodiazole-2-carboxylic acid)
• 849776-47-2(1H-Benzimidazole-2-carboxylic acid monohydrate)
• 910026-61-8(7-hydroxy-1H-Benzimidazole-2-carboxylic acid)
• 38786-60-6(6-methoxy-1H-1,3-benzodiazole-2-carbaldehyde)
• 889957-78-2(5-METHOXY-1H-BENZOIMIDAZOLE-2-CARBOXYLIC ACID ETHYL ESTER)