Cas no 88738-78-7 (Bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate)

Bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate structure
88738-78-7 structure
Product Name:Bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate
CAS No:88738-78-7
MF:C7H9F6O5P
MW:318.107544660568
MDL:MFCD00009901
CID:722554
PubChem ID:184894
Update Time:2024-10-26

Bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate Chemical and Physical Properties

Names and Identifiers

    • Methyl 2-(bis(2,2,2-trifluoroethoxy)phosphoryl)acetate
    • Bis(2,2,2-trifluoroethyl) (Methoxycarbonylmethyl)phosphonate
    • Acetic acid,2-[bis(2,2,2-trifluoroethoxy)phosphinyl]-, methyl ester
    • Methyl 2-(bis(2,2,2-trifluoroethoxy)-phosphoryl)acetate
    • methyl 2-[bis(2,2,2-trifluoroethoxy)phosphoryl]acetate
    • Methyl Bis(2,2,2-trifluoroethyl)phosphonoacetate
    • Methyl O,O'-bis(2,2,2-trifluoroethyl)phosphonoacetate
    • Bis(2,2,2-trifluoroethyl)phosphonoacetic Acid Methyl Ester
    • Methyl [Bis(2,2,2-trifluoroethoxy)phosphinyl]acetate
    • Aceticacid, [bis(2,2,2-trifluoroethoxy)phosphinyl]-, methyl ester (9CI)
    • Bis(2,2,2-trifluoroethyl) methyl phosphonoacetate
    • Methyl(bis(2,2,2-trifluoroethoxy)phosphinyl)acetate
    • Methyl[bis(2,2,2-trifluoroethyl)phosphono]acetate
    • NSC 634137
    • [(Methoxycarbonyl)methyl]phosphonic acid bis(2,2,2-trifluoroethyl) ester
    • [Bis(2,2,2-trifluoroethoxy)phosphoryl]acetic acid methyl ester
    • [Bis(2,2,2-trifluoroethyl)phosphono]acetic acid methyl ester
    • Methyl [bis(2,2,2-trifluoroethyl)phosphono]acetate
    • Acetic acid, [bis(2,2,2-trifluoroethoxy)phosphinyl]-, methyl ester (9CI)
    • Bis(2,2,2-trifluoroethyl) (2-methoxy-2-oxoethyl)phosphonate
    • Methyl (bis(2,2,2-trifluoroethoxy)phosphinyl)acetate
    • Methyl [bis(2,2,2-trifluoroethoxy)phosphoryl]acetate
    • Methyl P,P-bis(2,2,2-trifluoroethyl)phosphonoacetate
    • Acetic acid, [bis(2,2,2-trifluoroethoxy)phosphinyl]-, methyl ester
    • SY023287
    • CS-0150676
    • BBL102487
    • AKOS015909831
    • BP-12942
    • bis(2,2,2-trifluoroethyl)-(methoxycarbonylmethyl)phosphonoate
    • bis(2,2,2-trifluoroethyl)-(methoxycarbonylmethyl)phosphonate
    • methylbis(trifluoroethyl)phosphonoacetate
    • MFCD00009901
    • methyl P,P-bis(2,2,2-trifluoroethyl) phosphonoacetate
    • methyl [bis(2,2,2-trifluoroethoxy)-phosphoryl]acetate
    • bis(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonoate
    • methyl{bis[(2,2,2-trifluoroethyl)oxy]phosphoryl}acetate
    • methyl 2-[bis(2,2,2-trifluoroethyl) phosphono]acetate
    • AS-19998
    • bis(2,2,2-trifluoroethyl) (methoxycarbonyl-methyl)phosphonate
    • bis(2,2,2-trifluoroethyl)(methoxycarbonyl-methyl)phosphonate
    • Bis(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate
    • NSC634137
    • STL556290
    • B1714
    • SCHEMBL171078
    • DTXSID60237279
    • Methyl P,P-bis(2,2,2-trifluoroethyl)phosphonoacetate, 95%
    • DB-057101
    • EN300-298220
    • bis(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)-phosphonate
    • Methyl (bis(2,2,2-trifluoroethoxy)phosphoryl)acetate
    • bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)-phosphonate
    • NSC-634137
    • 88738-78-7
    • [Bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic methyl ester
    • Methyl Bis(2 pound not2 pound not2-trifluoroethyl)phosphonoacetate
    • methyl {bis[(2,2,2-trifluoroethyl)oxy]phosphoryl}acetate
    • Bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate
    • MDL： MFCD00009901
    • Inchi： 1S/C7H9F6O5P/c1-16-5(14)2-19(15,17-3-6(8,9)10)18-4-7(11,12)13/h2-4H2,1H3
    • InChI Key： PVSJXEDBEXYLML-UHFFFAOYSA-N
    • SMILES： O=C(CP(OCC(F)(F)F)(OCC(F)(F)F)=O)OC

Computed Properties

  • Exact Mass: 318.00900
  • Monoisotopic Mass: 318.009179
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 5
  • Heavy Atom Count: 19
  • Rotatable Bond Count: 9
  • Complexity: 329
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: 1.6
  • Topological Polar Surface Area: 61.8

Experimental Properties

  • Color/Form: Clear liquid
  • Density: 1.504?g/mL?at 25?°C(lit.)
  • Melting Point: No data available
  • Boiling Point: 246.6±40.0 oC (760 Torr),
  • Flash Point: Degrees Fahrenheit:230°F
    Degrees Celsius:110°C
  • Refractive Index: n20/D 1.370(lit.)
  • Solubility: Slightly soluble (11 g/l) (25 o C),
  • PSA: 71.64000
  • LogP: 2.51030
  • Solubility: Not determined

Bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate Security Information

Bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate Customs Data

  • HS CODE：2931900090
  • Customs Data：

    China Customs Code:

    2931900090

    Overview:

    2931900090. Other organic-Inorganic compound. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:AB(Customs clearance form for Inbound Goods,Customs clearance form for outbound goods). MFN tariff:6.5%. general tariff:30.0%

    Summary:

    2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

Bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate Pricemore >>

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Bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate
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abcr
AB138024-1 g
Bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate, 95%; .
 88738-78-7 95%
1g
 €88.20 2023-06-24
abcr
AB138024-5 g
Bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate, 95%; .
 88738-78-7 95%
5g
 €150.60 2023-06-24
abcr
AB138024-10 g
Bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate, 95%; .
 88738-78-7 95%
10g
 €213.00 2023-06-24
abcr
AB138024-25 g
Bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate, 95%; .
 88738-78-7 95%
25g
 €369.00 2023-06-24

Bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Triphenylphosphine ,  Iodine Solvents: Chloroform ;  15 min, rt
1.2 Reagents: Imidazole ;  15 min, rt; 30 min, 50 °C
1.3 5 h, 60 °C
Reference
Cooperative Palladium/Isothiourea Catalyzed Enantioselective Formal (3+2) Cycloaddition of Vinylcyclopropanes and α,β-Unsaturated Esters
Bitai, Jacqueline; Nimmo, Alastair J.; Slawin, Alexandra M. Z. ; Smith, Andrew D., Angewandte Chemie, 2022, 61(25),

Production Method 2

Reaction Conditions
1.1 Reagents: Triethylamine Solvents: Benzene
Reference
Trifluoroethanol
Crousse, Benoit; Legros, Julien, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2007, ,

Production Method 3

Reaction Conditions
1.1 Reagents: Bromotrimethylsilane Solvents: Dichloromethane ;  5 h, rt
1.2 Reagents: Triphenylphosphine ,  Iodine Solvents: Chloroform ;  15 min, rt
1.3 Reagents: Imidazole ;  15 min, rt; 30 min, 50 °C
1.4 Solvents: Chloroform ;  5 h, 60 °C
Reference
Facile Two-Step Synthesis of Methyl Bis(2,2,2-trifluoroethyl)phosphonoacetate by Exploiting Garegg-Samuelsson Reaction Conditions
Sano, Shigeki; Matsumoto, Tomoya; Toguchi, Munehisa; Nakao, Michiyasu, Synlett, 2018, 29(11), 1461-1464

Production Method 4

Reaction Conditions
1.1 Reagents: Triethylamine Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ;  0 °C; 1 d, rt
Reference
Stereoselective Synthesis of the Benzodihydropentalene Core of the Fijiolides
Kurzawa, Timon; Harms, Klaus; Koert, Ulrich, Organic Letters, 2018, 20(5), 1388-1391

Production Method 5

Reaction Conditions
1.1 Reagents: Chlorotrimethylsilane ;  4 d, 80 °C
1.2 Reagents: Oxalyl chloride Catalysts: Dimethylformamide Solvents: Dichloromethane ;  rt; 1 h, rt
1.3 Reagents: Triethylamine Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ;  cooled; 16 h, rt
Reference
An expedient access to Still-Gennari phosphonates
Messik, Frauke; Oberthuer, Markus, Synthesis, 2013, 45(2), 167-170

Production Method 6

Reaction Conditions
1.1 Solvents: Dichloromethane ;  5 min, rt; 10 min, rt
Reference
A Straightforward, Purification-Free Procedure for the Synthesis of Ando and Still-Gennari Type Phosphonates
Janicki, Ignacy ; Kielbasinski, Piotr, Synthesis, 2022, 54(2), 378-382

Production Method 7

Reaction Conditions
Reference
Asymmetric Total Synthesis of (2E)-Macrolactin 3
Reddy, Aedula Vishnu V.; Choudhury, Utkal Mani; Sarma, Akella V. S.; Mohapatra, Debendra K., Synlett, 2023, 34(1), 67-72

Production Method 8

Reaction Conditions
1.1 Solvents: Benzene
Reference
Methyl Bis(2,2,2-trifluoroethoxy)phosphinyl acetate
DeHoff, Brad; Roy, Marie-Noelle, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2012, 1, 1-4

Production Method 9

Reaction Conditions
1.1 Catalysts: Diisopropylethylamine
Reference
Direct synthesis of Z-unsaturated esters. A useful modification of the Horner-Emmons olefination
Still, W. Clark; Gennari, Cesare, Tetrahedron Letters, 1983, 24(41), 4405-8

Bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate Raw materials

Bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate Preparation Products

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Tiancheng Chemical (Jiangsu) Co., Ltd
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(CAS:88738-78-7)Methyl Bis(2,2,2-trifluoroethyl)phosphonoacetate
Order Number:LE7597
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 11:57
Price ($):discuss personally

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88738-78-7 (Bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate) Related Products

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Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:88738-78-7)Methyl Bis(2,2,2-trifluoroethyl)phosphonoacetate
LE7597
Purity:99%
Quantity:25KG,200KG,1000KG
Price ($):Inquiry
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