Production Method 1

1730-25-2

64248-63-1

886503-11-3

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride Solvents: Diethyl ether ;  1 h, 0 °C
1.2 24 h, -78 °C; -78 °C → 25 °C
1.3 Reagents: (Dimethyl sulfide)trihydroboron Solvents: Tetrahydrofuran ;  0 °C; 24 h, 25 °C
1.4 Reagents: Sodium hydroxide ,  Hydrogen peroxide Solvents: Methanol ,  Water ;  0 °C
1.5 Reagents: Thionyl chloride Solvents: 1,2-Dimethoxyethane ;  0 °C; 3 h, 25 °C
1.6 Reagents: Sodium hydroxide Solvents: Water ;  0 °C; 4 h, 25 °C

Reference

Synthesis of 2-substituted pyrrolidines from nitriles

Ramachandran, P. Veeraraghavan; Mitsuhashi, Wataru; Nicponski, Daniel R., Tetrahedron Letters, 2013, 54(37), 5001-5003

Production Method 2

2758623-48-0

886503-11-3

Reaction Conditions

1.1 Reagents: Sodium borohydride Solvents: Acetic acid ,  Methanol ;  1 h, rt

Reference

Rational drug design to explore the structure-activity relationship (SAR) of TRK inhibitors with 2,4-diaminopyrimidine scaffold

Wu, Tianxiao; Qin, Qiaohua; Liu, Nian ; Zhang, Chu; Lv, Ruicheng; et al, European Journal of Medicinal Chemistry, 2022, 230,

2-(3,5-difluorophenyl)pyrrolidine Raw materials

• Allylmagnesium Bromide (ca. 13% in Ethyl Ether, ca. 0.7mol/L)
• 2H-Pyrrole, 5-(3,5-difluorophenyl)-3,4-dihydro-
• 3,5-Difluorobenzonitrile

2-(3,5-difluorophenyl)pyrrolidine Preparation Products

• 2-(3,5-difluorophenyl)pyrrolidine (886503-11-3)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolidines Phenylpyrrolidines

• 72216-06-9(2-(4-Fluorophenyl)pyrrolidine)
• 298690-72-9(2-(3-Fluorophenyl)pyrrolidine)
• 298690-89-8((2R)-2-(4-fluorophenyl)pyrrolidine)
• 383130-06-1(2-(3-Fluorophenyl)azepane)
• 1364890-61-8((2R)-2-(3-fluorophenyl)pyrrolidine hydrochloride)
• 920274-04-0((2S)-2-(3-fluorophenyl)pyrrolidine)
• 298690-90-1((2S)-2-(4-fluorophenyl)pyrrolidine)
• 920274-03-9((2R)-2-(3-fluorophenyl)pyrrolidine)
• 77972-92-0(Pyrrolidine, 2-(3-fluorophenyl)-1-methyl-)
• 1193390-31-6(2-(3-Fluorophenyl)pyrrolidine Hydrochloride)