Production Method 1

13943-58-3

883546-16-5

886500-41-0

Reaction Conditions

1.1 Reagents: Tetrabutylammonium bromide Catalysts: Copper diacetate monohydrate ,  Potassium iodide Solvents: Water ;  22 h, 180 °C

Reference

Ligand-free Cu-catalyzed cyanation of aryl halides with K4[Fe(CN)6] in water

Ren, Yunlai; Zhao, Shuang; Tian, Xinzhe; Liu, Zhifei; Wang, Jianji; et al, Letters in Organic Chemistry, 2009, 6(7), 564-567

4-Chloro-2,6-difluorobenzonitrile Raw materials

• Potassium hexacyanoferrate
• 2-Bromo-5-chloro-1,3-difluorobenzene

4-Chloro-2,6-difluorobenzonitrile Preparation Products

• 4-Chloro-2,6-difluorobenzonitrile (886500-41-0)

• 1. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
• 2. Evolution study of photo-synthesized gold nanoparticles by spectral deconvolution model: a quantitative approach
  Chung-Sung Yang,Mong-Shian Shih,Fang-Yi Chang New J. Chem., 2006,30, 729-735
• 3. Excited state potential energy surfaces and their interactions in FeIVO active sites
  Shaun D. Wong,Edward I. Solomon Dalton Trans., 2014,43, 17567-17577
• 4. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
• 5. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzonitriles
• Solvents and Organic Chemicals Organic Compounds cyanides/Cyanides

• 57381-51-8(4-Chloro-2-fluorobenzonitrile)
• 135748-35-5(4-Chloro-2,5-difluorobenzonitrile)
• 94087-40-8(3-Chloro-2-fluorobenzonitrile)
• 86225-73-2(3-Chloro-2,6-difluorobenzonitrile)
• 57381-34-7(5-Chloro-2-fluorobenzonitrile)
• 887267-38-1(3-Chloro-2,4-difluorobenzonitrile)
• 886502-19-8(6-Chloro-2-fluoro-3-methylbenzonitrile)
• 668-45-1(2-Chloro-6-fluorobenzonitrile)
• 146780-26-9(5-Chloro-2,4-difluorobenzonitrile)
• 1897-50-3(5-Chloro-2,4,6-trifluoroisophthalonitrile)