Production Method 1

885590-98-7

885590-99-8

Reaction Conditions

1.1 Reagents: Piperidine, 2,2,6,6-tetramethyl-, lithium salt (1:1) Solvents: Tetrahydrofuran ;  < -65 °C; 15 min, -78 °C
1.2 Reagents: Iodine Solvents: Tetrahydrofuran ;  1 h, -78 °C; -78 °C → rt
1.3 Reagents: Water
1.4 Reagents: Hydrochloric acid Solvents: Tetrahydrofuran ,  Water ;  18 h, reflux; reflux → rt

Reference

7-Fluoroindazoles as Potent and Selective Inhibitors of Factor Xa

Lee, Yu-Kai; Parks, Daniel J.; Lu, Tianbao; Thieu, Tho V.; Markotan, Thomas; et al, Journal of Medicinal Chemistry, 2008, 51(2), 282-297

2,3-Difluoro-4-iodobenzaldehyde Raw materials

• 1,3-Dioxolane, 2-(2,3-difluoro-4-iodophenyl)-

2,3-Difluoro-4-iodobenzaldehyde Preparation Products

• 2,3-Difluoro-4-iodobenzaldehyde (885590-99-8)

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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoyl derivatives

• 61794-44-3(Benzene, 1,2,4,5-tetrafluoro-3-iodo-6-methyl-)
• 699016-40-5(2-Fluoro-4-iodobenzaldehyde)
• 914100-41-7(2,3-Difluoro-1-iodo-4-methylbenzene)
• 501433-05-2(2,3-Difluoro-4-iodobenzoic acid)
• 146137-83-9(2-Fluoro-3-iodobenzaldehyde)
• 1003709-57-6(3-Fluoro-4-iodobenzaldehyde)
• 146137-76-0(2-Fluoro-5-iodobenzaldehyde)
• 837368-26-0(Benzaldehyde, 2,3,5,6-tetrafluoro-4-iodo-)
• 1160573-10-3(2,6-Difluoro-4-iodobenzaldehyde)
• 873536-93-7(2,3,5,6-tetrafluoro-4-iodobenzoic acid)