Production Method 1

363-51-9

885453-49-6

Reaction Conditions

1.1 Reagents: Bromine Solvents: Dichloromethane ;  0 °C; 0 °C → rt; overnight, rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  rt

Reference

Rational Design of RNA Demethylase FTO Inhibitors with Enhanced Antileukemia Drug-Like Properties

Xiao, Pan; Duan, Zongliang; Liu, Zeyu; Chen, Liang; Zhang, Deyan; et al, Journal of Medicinal Chemistry, 2023, 66(14), 9731-9752

Production Method 2

363-51-9

885453-49-6

Reaction Conditions

1.1 Reagents: Bromine Solvents: Chloroform ;  30 - 60 min, rt
1.2 Reagents: Sodium thiosulfate Solvents: Dichloromethane ,  Water

Reference

Synthesis of dioxin-like monofluorinated PCBs: for the use as internal standards for PCB analysis

Sott, Richard; Hawner, Christine; Johansen, Jon E., Tetrahedron, 2008, 64(18), 4135-4142

4-bromo-2-chloro-6-fluoroaniline Raw materials

• 2-chloro-6-fluoro-aniline

4-bromo-2-chloro-6-fluoroaniline Preparation Products

• 4-bromo-2-chloro-6-fluoroaniline (885453-49-6)

• 1. Fe/S-Catalyzed synthesis of 2-benzoylbenzoxazoles and 2-quinolylbenzoxazoles via redox condensation of o-nitrophenols with acetophenones and methylquinolines?
  Thi Thu Tram Nguyen,Thanh Binh Nguyen Org. Biomol. Chem., 2021,19, 6015-6020
• 2. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
• 3. Emergence of microfluidic wearable technologies
  Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090
• 4. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
• 5. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
  Sowmyalakshmi Venkataraman RSC Adv., 2015,5, 73807-73813

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