Production Method 1

217813-03-1

885278-98-8

Reaction Conditions

1.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  24 h, -78 °C → rt

Reference

Synthesis and characterization of photoaffinity probes that target the 5-HT3 receptor

Jack, Thomas; Ruepp, Marc-David; Thompson, Andrew J.; Muhlemann, Oliver; Lochner, Martin, Chimia, 2014, 68(4), 239-242

Production Method 2

217813-03-1

885278-98-8

Reaction Conditions

1.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  -78 °C; -78 °C → rt; 20 h, rt

Reference

Synthesis of Indazoles by the [3+2] Cycloaddition of Diazo Compounds with Arynes and Subsequent Acyl Migration

Liu, Zhijian; Shi, Feng; Martinez, Pablo D. G.; Raminelli, Cristiano; Larock, Richard C., Journal of Organic Chemistry, 2008, 73(1), 219-226

Production Method 3

885278-98-8

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Ethanol ,  Water ;  rt; 12 h, rt
1.2 Reagents: Sodium carbonate ;  neutralized, rt

Reference

Toward Biophysical Probes for the 5-HT3 Receptor: Structure-Activity Relationship Study of Granisetron Derivatives

Vernekar, Sanjeev Kumar V.; Hallaq, Hasan Y.; Clarkson, Guy; Thompson, Andrew J.; Silvestri, Linda; et al, Journal of Medicinal Chemistry, 2010, 53(5), 2324-2328

Production Method 4

217813-03-1

885278-98-8

Reaction Conditions

1.1 Reagents: Potassium fluoride ,  18-Crown-6 Solvents: Tetrahydrofuran ;  24 h, rt

Reference

Facile and efficient synthesis of indazole derivatives by 1,3-cycloaddition of arynes with diazo compounds and azomethine imides

Jin, Tienan; Yang, Fan; Yamamoto, Yoshinori, Collection of Czechoslovak Chemical Communications, 2009, 74(6), 957-972

Production Method 5

217813-03-1

885278-98-8

Reaction Conditions

1.1 Reagents: Potassium fluoride ,  18-Crown-6 Solvents: Tetrahydrofuran ;  24 h, rt

Reference

An efficient, facile, and general synthesis of 1H-indazoles by 1,3-dipolar cycloaddition of arynes with diazomethane derivatives

Jin, Tienan; Yamamoto, Yoshinori, Angewandte Chemie, 2007, 46(18), 3323-3325

Production Method 6

217813-03-1

885278-98-8

Reaction Conditions

1.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  -78 °C; -78 °C → rt; rt
1.2 -

Reference

High-affinity fluorescent ligands for the 5-HT3 receptor

Simonin, Jonathan; Vernekar, Sanjeev Kumar V.; Thompson, Andrew J.; Hothersall, J. Daniel; Connolly, Christopher N.; et al, Bioorganic & Medicinal Chemistry Letters, 2012, 22(2), 1151-1155

Ethyl 7-methoxy-1H-indazole-3-carboxylate Raw materials

• 3-Methoxy-2-(trimethylsilyl)phenyl Trifluoromethanesulfonate

Ethyl 7-methoxy-1H-indazole-3-carboxylate Preparation Products

• Ethyl 7-methoxy-1H-indazole-3-carboxylate (885278-98-8)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzopyrazoles Indazoles

• 133841-08-4(7-Methoxy-1H-indazole-3-carboxylic acid)
• 29281-06-9(1H-Indazole-3-carboxylicacid, 5,6-dimethoxy-, ethyl ester)
• 885278-65-9(Methyl 7-Benzyloxy-1h-Indazole-3-Carboxylate)
• 885278-92-2(Ethyl 7-(benzyloxy)-1H-indazole-3-carboxylate)
• 885279-34-5(1H-Indazole-3-carboxylicacid, 5,6-dimethoxy-, methyl ester)
• 885278-62-6(Methyl 5-(benzyloxy)-1H-indazole-3-carboxylate)
• 885279-49-2(Ethyl 4-methoxy-1H-indazole-3-carboxylate)
• 885278-53-5(Methyl 6-methoxy-1H-indazole-3-carboxylate)
• 177941-17-2(7-Benzyloxy-1H-indazole-3-carboxylic acid)
• 885278-95-5(Methyl 7-methoxy-1H-indazole-3-carboxylate)