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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Thiazolecarboxylic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Thiazoles Thiazolecarboxylic acids and derivatives

Comprehensive Overview of 2-(4-Bromo-phenyl)-thiazole-4-carboxylic acid ethyl ester (CAS No. 885278-75-1)

The compound 2-(4-Bromo-phenyl)-thiazole-4-carboxylic acid ethyl ester (CAS No. 885278-75-1) is a highly versatile thiazole derivative that has garnered significant attention in pharmaceutical and agrochemical research. With its unique molecular structure featuring a bromophenyl group and an ethyl ester moiety, this compound serves as a critical intermediate in the synthesis of bioactive molecules. Researchers and industries are increasingly exploring its potential applications, particularly in drug discovery and material science, aligning with current trends in green chemistry and sustainable synthesis.

One of the most searched questions about 2-(4-Bromo-phenyl)-thiazole-4-carboxylic acid ethyl ester revolves around its synthetic routes and reaction mechanisms. The compound is typically synthesized via condensation reactions involving 4-bromobenzaldehyde and ethyl 2-chloroacetoacetate, followed by cyclization to form the thiazole ring. This process highlights the growing demand for efficient catalytic methods and atom-economical transformations, which are hot topics in modern organic chemistry. Additionally, its solubility in common organic solvents like DMSO and ethanol makes it a practical choice for laboratory-scale applications.

In the context of drug development, 2-(4-Bromo-phenyl)-thiazole-4-carboxylic acid ethyl ester is often investigated for its pharmacophore properties. The thiazole core is known to exhibit diverse biological activities, including antimicrobial and anti-inflammatory effects. Recent studies have linked derivatives of this compound to potential kinase inhibition, a key area in cancer therapeutics. Such findings resonate with the rising interest in targeted therapies and personalized medicine, which dominate scientific discussions today.

From an industrial perspective, the compound’s stability under ambient conditions and ease of purification make it a preferred choice for scale-up processes. Its melting point (typically ranging between 120–125°C) and spectroscopic data (e.g., NMR and IR spectra) are well-documented, aiding in quality control. These attributes align with the increasing focus on process optimization and cost-effective manufacturing in the fine chemicals sector.

Environmental and regulatory considerations are also pivotal when discussing 2-(4-Bromo-phenyl)-thiazole-4-carboxylic acid ethyl ester. While the compound is not classified as hazardous, its handling protocols emphasize the use of personal protective equipment (PPE) to minimize exposure. This reflects broader industry shifts toward occupational safety and regulatory compliance, particularly in regions with stringent chemical regulations like the EU and North America.

In summary, 2-(4-Bromo-phenyl)-thiazole-4-carboxylic acid ethyl ester (CAS No. 885278-75-1) represents a compelling case study at the intersection of synthetic chemistry, drug discovery, and industrial applications. Its relevance to contemporary research themes—such as catalyst design, therapeutic innovation, and sustainable production—ensures its continued prominence in scientific literature and commercial pipelines alike.

• 7113-02-2(4-Thiazolecarboxylicacid, 2-phenyl-, methyl ester)
• 730234-73-8(2-(4-Amino-phenyl)-thiazole-4-carboxylic Acid ethyl ester)
• 132089-33-9(ethyl 2-m-tolylthiazole-4-carboxylate)
• 885278-51-3(2-(o-Tolyl)-thiazole-4-carboxylic Acid Ethyl Ester)
• 132089-32-8(2-p-Tolyl-thiazole-4-carboxylic Acid Ethyl Ester)
• 59937-01-8(ethyl 2-phenyl-1,3-thiazole-4-carboxylate)
• 21160-50-9(2-(4-Bromophenyl)thiazole-4-carboxylic acid)
• 11334-60-4(2-(4-Hydroxyphenyl)thiazole-4-carboxylic acid ethyl ester)
• 89401-56-9(Ethyl 2-(pyridin-4-yl)-1,3-thiazole-4-carboxylate hydrobromide)
• 786654-97-5(2-(3-Bromo-phenyl)-thiazole-4-carboxylic acid ethyl ester)