Cas no 885277-08-7 (5-Chloropyridine-2-sulfonyl chloride)

5-Chloropyridine-2-sulfonyl chloride is a versatile sulfonylating reagent widely used in organic synthesis and pharmaceutical applications. Its key advantages include high reactivity as a sulfonyl chloride derivative, enabling efficient introduction of the 5-chloropyridine-2-sulfonyl moiety into target molecules. The compound serves as a valuable intermediate for constructing sulfonamides, sulfonate esters, and other functionalized pyridine derivatives. Its electron-withdrawing chloropyridine ring enhances electrophilicity, facilitating nucleophilic substitution reactions. The product is particularly useful in medicinal chemistry for modifying bioactive compounds or developing new drug candidates. Careful handling is required due to its moisture sensitivity and reactivity. It is typically stored under inert conditions to maintain stability.
5-Chloropyridine-2-sulfonyl chloride structure
885277-08-7 structure
Product Name:5-Chloropyridine-2-sulfonyl chloride
CAS No:885277-08-7
MF:C5H3Cl2NO2S
MW:212.053817987442
MDL:MFCD06739113
CID:711412
PubChem ID:44558098
Update Time:2025-05-27

5-Chloropyridine-2-sulfonyl chloride Chemical and Physical Properties

Names and Identifiers

    • 5-Chloropyridine-2-sulfonyl chloride
    • 2-Pyridinesulfonylchloride, 5-chloro-
    • 5-CHLORO-PYRIDINE-2-SULFONYL CHLORIDE
    • 5-Chloro-2-pyridinesulfonyl chloride (ACI)
    • SCHEMBL1465207
    • AKOS010078372
    • ZPHYQPBAPHPVAL-UHFFFAOYSA-N
    • CS-0044336
    • EN300-149920
    • AB28625
    • BS-17875
    • 885277-08-7
    • 5-Chloropyridine-2-sulfonylchloride
    • MFCD06739113
    • 2-Pyridinesulfonylchloride,5-chloro-
    • DTXSID70659342
    • MDL： MFCD06739113
    • Inchi： 1S/C5H3Cl2NO2S/c6-4-1-2-5(8-3-4)11(7,9)10/h1-3H
    • InChI Key： ZPHYQPBAPHPVAL-UHFFFAOYSA-N
    • SMILES： O=S(C1C=CC(Cl)=CN=1)(Cl)=O

Computed Properties

  • Exact Mass: 210.92600
  • Monoisotopic Mass: 210.9261549g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 1
  • Complexity: 223
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: 1.8
  • Topological Polar Surface Area: 55.4?2

Experimental Properties

  • PSA: 55.41000
  • LogP: 2.74330

5-Chloropyridine-2-sulfonyl chloride Pricemore >>

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5-Chloropyridine-2-sulfonyl chloride Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Sulfuric acid ,  Sodium hypochlorite Solvents: Water ;  4 h, 0 °C
1.2 Reagents: Chlorine
Reference
Desulfonative Suzuki-Miyaura Coupling of Sulfonyl Fluorides
Chatelain, Paul; Muller, Cyprien ; Sau, Abhijit ; Brykczynska, Daria; Bahadori, Maryam ; et al, Angewandte Chemie, 2021, 60(48), 25307-25312

5-Chloropyridine-2-sulfonyl chloride Raw materials

5-Chloropyridine-2-sulfonyl chloride Preparation Products

5-Chloropyridine-2-sulfonyl chloride Related Literature

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