Production Method 1

1493-13-6

885273-81-4

Reaction Conditions

1.1 0 °C; 30 min, 25 °C

Reference

Synthesis of Medium-Ring-sized Benzolactams by Using Strong Electrophiles and Quantitative Evaluation of Ring-size Dependency of the Cyclization Reaction Rate

Kurouchi, Hiroaki; Ohwada, Tomohiko, Journal of Organic Chemistry, 2020, 85(2), 876-901

Production Method 2

1403029-66-2

885273-81-4

52516-13-9

Reaction Conditions

1.1 Reagents: Trifluoromethanesulfonic acid ;  0 °C; 45 h, 70 °C

Reference

Activation of Electrophilicity of Stable Y-Delocalized Carbamate Cations in Intramolecular Aromatic Substitution Reaction: Evidence for Formation of Diprotonated Carbamates Leading to Generation of Isocyanates

Kurouchi, Hiroaki; Kawamoto, Kyoko; Sugimoto, Hiromichi; Nakamura, Satoshi; Otani, Yuko; et al, Journal of Organic Chemistry, 2012, 77(20), 9313-9328

5,7-Dichloro-3,4-dihydro-2H-isoquinolin-1-one Raw materials

• Trifluoromethanesulfonic acid
• Carbamic acid, N-[2-(2,4-dichlorophenyl)ethyl]-, methyl ester

5,7-Dichloro-3,4-dihydro-2H-isoquinolin-1-one Preparation Products

• 2,4-Dichlorophenethylamine (52516-13-9)
• 5,7-Dichloro-3,4-dihydro-2H-isoquinolin-1-one (885273-81-4)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Isoquinolines and derivatives Isoquinolones and derivatives

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)