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Comprehensive Overview of 2-(4-Phenylmethoxyphenyl)-1,3-Oxazol-4-YlMethanamine (CAS No. 885273-44-9): Properties, Applications, and Research Insights

The compound 2-(4-Phenylmethoxyphenyl)-1,3-Oxazol-4-YlMethanamine (CAS No. 885273-44-9) is a specialized organic molecule that has garnered significant attention in pharmaceutical and materials science research. This oxazole derivative features a unique structural framework, combining a phenylmethoxyphenyl moiety with an oxazole ring and a terminal methanamine group. Its molecular architecture makes it a promising candidate for various applications, particularly in drug discovery and functional material design.

Recent trends in scientific literature highlight growing interest in heterocyclic compounds like 2-(4-Phenylmethoxyphenyl)-1,3-Oxazol-4-YlMethanamine, as researchers explore their potential as kinase inhibitors and GPCR modulators. The compound's CAS No. 885273-44-9 frequently appears in patent filings related to neurodegenerative disease therapeutics and anti-inflammatory agents, aligning with current healthcare priorities such as Alzheimer's research and chronic pain management.

From a chemical perspective, the oxazole core in 2-(4-Phenylmethoxyphenyl)-1,3-Oxazol-4-YlMethanamine provides remarkable stability and hydrogen-bonding capacity, while the methanamine tail offers functionalization potential. This duality enables the compound to serve as both a pharmacophore and a molecular scaffold. Analytical studies using HPLC-MS and NMR spectroscopy confirm its high purity (>98%) when synthesized under optimized conditions, making it valuable for precision applications.

The synthesis of CAS No. 885273-44-9 typically involves a multi-step process starting from 4-hydroxybenzaldehyde derivatives, followed by oxazole ring formation through cyclization reactions. Recent advancements in green chemistry approaches have improved yield efficiency while reducing environmental impact—a crucial consideration given increasing focus on sustainable synthesis in the chemical industry.

In pharmacological contexts, preliminary studies suggest that 2-(4-Phenylmethoxyphenyl)-1,3-Oxazol-4-YlMethanamine may influence cell signaling pathways associated with metabolic regulation. This has sparked investigations into its potential role in diabetes management and obesity-related disorders, topics frequently searched in medical databases. However, researchers emphasize that extensive in vivo studies are needed to validate these observations.

Material scientists have explored CAS No. 885273-44-9 for its photophysical properties, with particular interest in its fluorescence characteristics. The compound's ability to exhibit solvatochromism makes it a candidate for sensor development—a hot topic in environmental monitoring and diagnostic technologies. Its electron-rich structure also shows promise in organic electronics, especially for OLED components.

Quality control protocols for 2-(4-Phenylmethoxyphenyl)-1,3-Oxazol-4-YlMethanamine emphasize chromatographic purity assessment and structural confirmation via FT-IR spectroscopy. Storage recommendations typically suggest anhydrous conditions at -20°C to maintain stability, addressing common concerns about compound degradation raised in research forums.

Emerging computational chemistry studies utilizing molecular docking simulations predict favorable interactions between 885273-44-9 and various enzyme active sites. These in silico analyses, combined with QSAR modeling, help prioritize the most promising biological targets for experimental validation—a strategy increasingly adopted in drug discovery pipelines to reduce development costs.

The global market for fine chemicals like 2-(4-Phenylmethoxyphenyl)-1,3-Oxazol-4-YlMethanamine reflects growing demand from both academic research and industrial R&D sectors. Suppliers frequently receive inquiries about custom synthesis options and bulk quantities, indicating its expanding utility. Regulatory documentation emphasizes compliance with REACH guidelines and proper safety data sheets for handling.

Future research directions for CAS No. 885273-44-9 may explore its structure-activity relationships through systematic derivatization studies. The compound's modular architecture allows for targeted modifications at the oxazole position or amine group, enabling creation of specialized analogs for specific applications—a strategy gaining traction in precision medicine development.

• 95128-29-3(Benzoxazole, 2-[4-(phenylmethoxy)phenyl]-)
• 885273-76-7(4-Oxazolemethanol,2-(4-methoxyphenyl)-)
• 885274-29-3(4-Oxazolemethanamine,2-(2-methoxyphenyl)-)
• 885273-30-3(2-[4-(benzyloxy)phenyl]-1,3-oxazole-4-carbaldehyde)
• 179170-38-8(BENZENEMETHANOL, 4-[2-(2-PHENYL-4-OXAZOLYL)ETHOXY]-)
• 885273-48-3(4-Oxazolemethanamine,2-(1,3-benzodioxol-5-yl)-)
• 1031655-08-9([2-(4-methoxy-phenyl)-5-methyl-oxazol-4-yl]-methylamine)
• 885273-17-6(2-(3-methoxyphenyl)-1,3-oxazol-4-ylmethanamine)
• 885273-38-1(4-Oxazolemethanamine,2-(3,4-dimethylphenyl)-)
• 885272-87-7(C-2-(4-Methoxyphenyl)oxazol-4-ylmethylamine)