Cas no 885270-79-1 ((2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester)

(2-Amino-6-methyl-phenyl)carbamic acid tert-butyl ester is a protected aniline derivative widely used as an intermediate in organic synthesis and pharmaceutical development. Its tert-butyloxycarbonyl (Boc) group provides stability under basic and nucleophilic conditions while allowing selective deprotection under acidic conditions, making it valuable for stepwise reactions. The compound’s methyl substitution enhances steric control in coupling reactions, improving regioselectivity. It is particularly useful in peptide and heterocycle synthesis, where protecting group strategies are critical. The crystalline solid form ensures consistent handling and purity, while its well-defined reactivity profile supports reproducible results in complex multi-step syntheses.

(2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester structure

885270-79-1 structure

Product Name:(2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester

CAS No:885270-79-1

MF:C₁₂H₁₈N₂O₂

MW:222.283523082733

MDL:MFCD05663968

CID:710754

PubChem ID:43152277

Update Time:2025-05-28

(2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester Chemical and Physical Properties

Names and Identifiers

- Carbamic acid,N-(2-amino-6-methylphenyl)-, 1,1-dimethylethyl ester
- (2-AMINO-6-METHYL-PHENYL)CARBAMIC ACID TERT-BUTYL ESTER,
- tert-butyl N-(2-amino-6-methylphenyl)carbamate
- (2-AMINO-6-METHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER
- tert-Butyl (2-amino-6-methylphenyl)carbamate
- 1,1-Dimethylethyl N-(2-amino-6-methylphenyl)carbamate (ACI)
- Carbamic acid, (2-amino-6-methylphenyl)-, 1,1-dimethylethyl ester (9CI)
- (2-Amino-6-methyl-phenyl)-carbamic acid t-butyl ester
- MFCD05663968
- CS-0342280
- SCHEMBL3577461
- tert-Butyl(2-amino-6-methylphenyl)carbamate
- AKOS009329015
- (2-Amino-6-methyl-phenyl)-carbamic acid tert-butyl ester, AldrichCPR
- DTXSID20655591
- AB22083
- 885270-79-1
- (2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester
- MDL： MFCD05663968
- Inchi： 1S/C12H18N2O2/c1-8-6-5-7-9(13)10(8)14-11(15)16-12(2,3)4/h5-7H,13H2,1-4H3,(H,14,15)
- InChI Key： DUMFKNCZZQVNHD-UHFFFAOYSA-N
- SMILES： O=C(NC1C(C)=CC=CC=1N)OC(C)(C)C

Computed Properties

Exact Mass: 222.13700
Monoisotopic Mass: 222.137
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 4
Heavy Atom Count: 16
Rotatable Bond Count: 4
Complexity: 248
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Surface Charge: 0
Tautomer Count: 2
XLogP3: nothing
Topological Polar Surface Area: 64.4A^2

Experimental Properties

PSA: 64.35000
LogP: 3.57840

(2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester Customs Data

HS CODE：2924299090
Customs Data：

China Customs Code:
2924299090

Overview:

2924299090. Other cyclic amides(Including cyclic carbamates)(Including their derivatives as well as their salts). VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%

Declaration elements:

Product Name, component content, use to, packing

Summary:

2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

(2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
TRC	A898970-50mg	(2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester	885270-79-1		50mg	$ 70.00	2022-06-01
TRC	A898970-100mg	(2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester	885270-79-1		100mg	$ 95.00	2022-06-01
TRC	A898970-500mg	(2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester	885270-79-1		500mg	$ 365.00	2022-06-01
JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd.	20R0118-1g	(2-Amino-6-methyl-phenyl)-carbamic acid tert-butyl ester	885270-79-1	97%	1g	5071.29CNY	2021-05-08
JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd.	20R0118-5g	(2-Amino-6-methyl-phenyl)-carbamic acid tert-butyl ester	885270-79-1	97%	5g	20268.21CNY	2021-05-08
JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd.	20R0118-500mg	(2-Amino-6-methyl-phenyl)-carbamic acid tert-butyl ester	885270-79-1	97%	500mg	2959.67CNY	2021-05-08
JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd.	20R0118-250mg	(2-Amino-6-methyl-phenyl)-carbamic acid tert-butyl ester	885270-79-1	97%	250mg	1908.1CNY	2021-05-08
JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd.	20R0118-100mg	(2-Amino-6-methyl-phenyl)-carbamic acid tert-butyl ester	885270-79-1	97%	100mg	1382.31CNY	2021-05-08
JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd.	20R0118-50mg	(2-Amino-6-methyl-phenyl)-carbamic acid tert-butyl ester	885270-79-1	97%	50mg	1110.94CNY	2021-05-08
eNovation Chemicals LLC	D967427-100mg	(2-Amino-6-methyl-phenyl)-carbamic acid tert-butyl ester	885270-79-1	95%	100mg	$340	2024-07-28

(2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester Production Method

Production Method 1

885953-51-5

885270-79-1

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ; overnight, rt

Reference

2-Aminopyrimidine Derivatives as New Selective Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors

Mo, Cheng; et al, ACS Medicinal Chemistry Letters, 2017, 8(5), 543-548

Production Method 2

24424-99-5

570-24-1

885270-79-1

Reaction Conditions

1.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: Tetrahydrofuran ; 3 h, reflux; reflux → rt
1.2 Reagents: Potassium carbonate Solvents: Methanol ; 3 h, reflux
2.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ; overnight, rt

Reference

2-Aminopyrimidine Derivatives as New Selective Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors

Mo, Cheng; et al, ACS Medicinal Chemistry Letters, 2017, 8(5), 543-548

(2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester Raw materials

(2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester Preparation Products

(2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester (885270-79-1)

(2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester Related Literature

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Related Categories

Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylcarbamic acid esters

885270-79-1 ((2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester) Related Products

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Cas no 885270-79-1 ((2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester)

(2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester Chemical and Physical Properties

Names and Identifiers

Computed Properties

Experimental Properties

(2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester Customs Data

China Customs Code:

Overview:

Declaration elements:

Summary:

(2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester Pricemore >>

(2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester Production Method

Production Method 1

Production Method 2

(2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester Raw materials

(2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester Preparation Products

(2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester Related Literature

Related Categories

885270-79-1 ((2-Amino-6-methyl-phenyl)carbamic Acid tert-butyl ester) Related Products