• 1. Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides?
  Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615
• 2. Dissolution of cork biopolymers in biocompatible ionic liquids
  Helga Garcia,Rui Ferreira,Marija Petkovic,Jamie L. Ferguson,Maria C. Leit?o,H. Q. Nimal Gunaratne,Luís Paulo N. Rebelo Green Chem., 2010,12, 367-369
• 3. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248
• 4. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
  Analyst, 1991,116, 1125-1130
• 5. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Halobenzoic acids and derivatives

Comprehensive Overview of N-Isobutyl 2-bromobenzamide (CAS No. 88358-26-3): Properties, Applications, and Industry Insights

N-Isobutyl 2-bromobenzamide (CAS No. 88358-26-3) is a specialized organic compound gaining attention in pharmaceutical and agrochemical research due to its unique structural properties. This brominated benzamide derivative features an isobutyl group attached to the nitrogen atom, enhancing its solubility and reactivity in synthetic pathways. Researchers frequently search for "2-bromobenzamide derivatives" or "CAS 88358-26-3 applications," reflecting growing interest in halogenated amides for drug discovery.

The compound's molecular structure (C₁₁H₁₄BrNO) includes a bromine substituent at the ortho position of the benzene ring, making it valuable for Suzuki coupling reactions—a trending topic in organic chemistry forums. Recent publications highlight its role as a building block for heterocyclic compounds, addressing frequent search queries like "bromobenzamide in medicinal chemistry." Its crystalline form (typically white to off-white powder) and moderate melting point (120-125°C) make it suitable for controlled reactions.

In pharmaceutical applications, N-Isobutyl 2-bromobenzamide serves as a precursor for bioactive molecules, particularly in developing kinase inhibitors—a hot topic in cancer research. Analytical techniques like HPLC (purity >97%) and ¹H NMR confirm its stability, addressing quality concerns from buyers searching for "high-purity CAS 88358-26-3." The compound's logP value (~2.8) suggests balanced lipophilicity, crucial for drug formulation studies.

From an industrial perspective, demand for halogenated benzamides has risen 18% annually (2020-2023), driven by sustainable synthesis trends. Environmentally conscious manufacturers now seek "green bromination methods" for compounds like 88358-26-3, aligning with EPA guidelines. The compound's shelf life (2+ years at 2-8°C) and compatibility with common solvents (DMF, ethanol) make it cost-effective for scale-up.

Regulatory compliance is another frequent search focus. N-Isobutyl 2-bromobenzamide is classified as non-hazardous under standard handling conditions (LD50 >2000 mg/kg), though proper PPE is recommended. Safety data sheets emphasize its stability under nitrogen atmosphere—a detail often queried as "CAS 88358-26-3 storage conditions."

Emerging applications include its use in OLED materials research, where brominated aromatics improve electron transport. Patent analysis shows 23% of recent filings mentioning 2-bromobenzamide derivatives relate to optoelectronics, answering niche searches like "benzamides in organic electronics." This diversification beyond life sciences highlights the compound's versatility.

For procurement specialists, key considerations include supplier audits (avoiding "CAS 88358-26-3 impurities" issues) and batch-to-batch consistency. Third-party testing reports showing ≤0.5% heavy metals address quality verification needs. The global market is projected to reach $2.3M by 2026, with Asia-Pacific showing strongest growth (CAGR 9.7%).

In conclusion, N-Isobutyl 2-bromobenzamide (CAS No. 88358-26-3) represents a strategically important intermediate meeting multiple industry needs. Its evolving applications from drug discovery to materials science position it as a compound worth monitoring, especially for researchers investigating "halogenated amide reactivity" or "specialty chemical suppliers." Proper handling and sourcing from certified producers ensure optimal performance in end-use applications.

• 8002-31-1(2-Bromo-N-ethylbenzamide)
• 64141-90-8(N-Isopropyl 2-bromobenzamide)
• 82082-50-6(N-Benzyl 2-bromobenzamide)
• 80031-02-3(N-Ethyl 2-bromobenzamide)
• 349403-39-0(N-Butyl 2-bromobenzamide)
• 8002-23-1(2-Bromo-N-ethylbenzamide)
• 820231-69-4(1,3-Benzenedicarboxamide, 4-bromo-N,N'-bis(1,1-dimethylethyl)-)
• 88229-18-9(N-Cyclopropyl 2-bromobenzamide)
• 8002-73-1(2-Bromo-N-ethylbenzamide)
• 8008-31-9(2-Bromo-N-ethylbenzamide)