Cas no 88319-43-1 ((2R)-2-amino-4,4-dimethylpentanoic acid)

(2R)-2-amino-4,4-dimethylpentanoic acid structure
88319-43-1 structure
Product Name:(2R)-2-amino-4,4-dimethylpentanoic acid
CAS No:88319-43-1
MF:C7H15NO2
MW:145.199502229691
MDL:MFCD00038404
CID:720979
PubChem ID:6950508
Update Time:2024-10-26

(2R)-2-amino-4,4-dimethylpentanoic acid Chemical and Physical Properties

Names and Identifiers

    • (R)-2-Amino-4,4-dimethylpentanoic acid
    • 3-tertbutyl-D-β-alanine
    • BETA-T-BUTYL-D-ALANINE
    • D-Neopentylglycine
    • H-D-NptGly-OH
    • H-β-tBu-D-Ala-OH
    • Pentanoic acid,2-amino-4,4-dimethyl-, (2R)-
    • β-tert-Butyl-D-alanine
    • H-D-beta-tbu-Ala-OH
    • 4-Methyl-D-leucine
    • (2R)-2-amino-4,4-dimethylpentanoic acid
    • (2R)-2-Amino-4,4-dimethylpentanoic acid (ACI)
    • D-Leucine, 4-methyl- (9CI)
    • (R)-2-Amino-4,4-dimethylpentanoicacid
    • D-tert-Butylalanine
    • γ-Methyl-D-leucine
    • AC-6597
    • AKOS006272330
    • DTXSID90426199
    • 88319-43-1
    • DS-6589
    • 3-tert-butyl-D-alanine
    • BETA-TERT-BUTYL-D-ALANINE
    • (R)-2-AMINO-4,4-DIMETHYL-PENTANOIC ACID
    • SCHEMBL197139
    • LPBSHGLDBQBSPI-RXMQYKEDSA-N
    • H-D-ALA(TBU)-OH
    • H-BETA-TBU-D-ALA-OH
    • H-D-tBuAla-OH
    • H--tBu-D-Ala-OH
    • CS-0053492
    • DB-290161
    • (2R)-2-amino-4,4-dimethyl-pentanoic acid
    • H-D-Neopentylgly-OH;H--Me-D-Leu-OH;H-D-Tba-OH
    • MFCD00038404
    • EN300-295099
    • D-Leucine, 4-methyl-
    • MDL： MFCD00038404
    • Inchi： 1S/C7H15NO2/c1-7(2,3)4-5(8)6(9)10/h5H,4,8H2,1-3H3,(H,9,10)/t5-/m1/s1
    • InChI Key： LPBSHGLDBQBSPI-RXMQYKEDSA-N
    • SMILES： [C@H](N)(C(=O)O)CC(C)(C)C

Computed Properties

  • Exact Mass: 145.110278721g/mol
  • Monoisotopic Mass: 145.110278721g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 10
  • Rotatable Bond Count: 3
  • Complexity: 126
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 1
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: -1.3
  • Topological Polar Surface Area: 63.3?2

Experimental Properties

  • Color/Form: White to Yellow Solid
  • Density: 1.016
  • Boiling Point: 236 oC
  • Flash Point: 97 oC
  • Refractive Index: 1.471
  • PSA: 63.32000
  • LogP: 1.53480

(2R)-2-amino-4,4-dimethylpentanoic acid Security Information

(2R)-2-amino-4,4-dimethylpentanoic acid Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
NAN JING YAO SHI KE JI GU FEN Co., Ltd.
PB92805-1 G
(2R)-2-amino-4,4-dimethylpentanoic acid
 88319-43-1 97%
1g
 ￥ 1,254.00 2021-05-07
NAN JING YAO SHI KE JI GU FEN Co., Ltd.
PB92805-5 G
(2R)-2-amino-4,4-dimethylpentanoic acid
 88319-43-1 97%
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NAN JING YAO SHI KE JI GU FEN Co., Ltd.
PB92805-10 G
(2R)-2-amino-4,4-dimethylpentanoic acid
 88319-43-1 97%
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NAN JING YAO SHI KE JI GU FEN Co., Ltd.
PB92805-25 G
(2R)-2-amino-4,4-dimethylpentanoic acid
 88319-43-1 97%
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SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
H187615-1g
(2R)-2-amino-4,4-dimethylpentanoic acid
 88319-43-1 96%
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SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
H187615-250mg
(2R)-2-amino-4,4-dimethylpentanoic acid
 88319-43-1 96%
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SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
H187615-5g
(2R)-2-amino-4,4-dimethylpentanoic acid
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AstaTech
51152-1/G
3-TERT-BUTYL-D-ALANINE
 88319-43-1 97%
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AstaTech
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3-TERT-BUTYL-D-ALANINE
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AstaTech
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 88319-43-1 97%
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(2R)-2-amino-4,4-dimethylpentanoic acid Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ;  3 h, rt
1.2 Reagents: Sodium carbonate Solvents: Water ;  pH 9
Reference
In vitro synthesis of new cyclodepsipeptides of the PF1022-type: probing the α-D-hydroxy acid tolerance of PF1022 synthetase
Mueller, Jane; et al, ChemBioChem, 2009, 10(2), 323-328

Production Method 2

Reaction Conditions
1.1 Reagents: Triethylamine Solvents: Dimethylformamide
2.1 Catalysts: Cuprous iodide Solvents: Tetrahydrofuran
2.2 Reagents: Methanol
3.1 Reagents: Hydrogen Catalysts: Palladium dihydroxide Solvents: Methanol ,  Tetrahydrofuran
3.2 Reagents: Hydrochloric acid Solvents: Ethanol
3.3 Reagents: Ammonium hydroxide
3.4 Reagents: Dowex 50W Solvents: Water
Reference
Asymmetric Synthesis of α-Amino Acids by Copper-Catalyzed Conjugate Addition of Grignard Reagents to Optically Active Carbamatoacrylates
Lander, Peter A.; et al, Journal of the American Chemical Society, 1994, 116(18), 8126-32

Production Method 3

Reaction Conditions
1.1 Reagents: Piperidine, 2,2,6,6-tetramethyl-, lithium salt (1:1) Solvents: Tetrahydrofuran ,  Hexane
2.1 Reagents: Butyllithium Solvents: Diethyl ether ,  Pentane ,  Tetrahydrofuran ,  Hexane
2.2 -
2.3 Reagents: Hydrochloric acid Solvents: Water
3.1 Reagents: Triethylamine Solvents: Dimethylformamide
4.1 Catalysts: Cuprous iodide Solvents: Tetrahydrofuran
4.2 Reagents: Methanol
5.1 Reagents: Hydrogen Catalysts: Palladium dihydroxide Solvents: Methanol ,  Tetrahydrofuran
5.2 Reagents: Hydrochloric acid Solvents: Ethanol
5.3 Reagents: Ammonium hydroxide
5.4 Reagents: Dowex 50W Solvents: Water
Reference
Asymmetric Synthesis of α-Amino Acids by Copper-Catalyzed Conjugate Addition of Grignard Reagents to Optically Active Carbamatoacrylates
Lander, Peter A.; et al, Journal of the American Chemical Society, 1994, 116(18), 8126-32

Production Method 4

Reaction Conditions
1.1 Reagents: Hydrogen bromide Solvents: Water
Reference
Peptides containing a neopentylglycine residue
Pospisek, Jan; et al, Collection of Czechoslovak Chemical Communications, 1987, 52(2), 514-21

Production Method 5

Reaction Conditions
1.1 Reagents: Hydrogen Catalysts: Palladium dihydroxide Solvents: Methanol ,  Tetrahydrofuran
1.2 Reagents: Hydrochloric acid Solvents: Ethanol
1.3 Reagents: Ammonium hydroxide
1.4 Reagents: Dowex 50W Solvents: Water
Reference
Asymmetric Synthesis of α-Amino Acids by Copper-Catalyzed Conjugate Addition of Grignard Reagents to Optically Active Carbamatoacrylates
Lander, Peter A.; et al, Journal of the American Chemical Society, 1994, 116(18), 8126-32

Production Method 6

Reaction Conditions
1.1 Reagents: 2,2-Diphenylglycine Catalysts: Benzeneacetamide, N-[(R)-[4-(aminomethyl)-5-hydroxy-3-pyridinyl][1,1′-biphenyl]-… Solvents: Methanol ,  Water ;  3 d, 20 °C
Reference
A new type of chiral-pyridoxamines for catalytic asymmetric transamination of α-keto acids
Chen, Jianfeng; et al, Tetrahedron Letters, 2016, 57(41), 4612-4615

Production Method 7

Reaction Conditions
1.1 Catalysts: Cuprous iodide Solvents: Tetrahydrofuran
1.2 Reagents: Methanol
2.1 Reagents: Hydrogen Catalysts: Palladium dihydroxide Solvents: Methanol ,  Tetrahydrofuran
2.2 Reagents: Hydrochloric acid Solvents: Ethanol
2.3 Reagents: Ammonium hydroxide
2.4 Reagents: Dowex 50W Solvents: Water
Reference
Asymmetric Synthesis of α-Amino Acids by Copper-Catalyzed Conjugate Addition of Grignard Reagents to Optically Active Carbamatoacrylates
Lander, Peter A.; et al, Journal of the American Chemical Society, 1994, 116(18), 8126-32

Production Method 8

Reaction Conditions
1.1 -
2.1 Reagents: 2,2-Diphenylglycine Catalysts: Benzeneacetamide, N-[(R)-[4-(aminomethyl)-5-hydroxy-3-pyridinyl][1,1′-biphenyl]-… Solvents: Methanol ,  Water ;  3 d, 20 °C
Reference
A new type of chiral-pyridoxamines for catalytic asymmetric transamination of α-keto acids
Chen, Jianfeng; et al, Tetrahedron Letters, 2016, 57(41), 4612-4615

Production Method 9

Reaction Conditions
1.1 Reagents: Trimethyltin chloride ,  Piperidine, 2,2,6,6-tetramethyl-, lithium salt (1:1) Solvents: Tetrahydrofuran ,  Hexane
1.2 Reagents: Butyllithium Solvents: Diethyl ether ,  Pentane ,  Tetrahydrofuran ,  Hexane
1.3 -
1.4 Reagents: Hydrochloric acid Solvents: Water
1.5 Reagents: Triethylamine Solvents: Dimethylformamide
2.1 Catalysts: Cuprous iodide Solvents: Tetrahydrofuran
2.2 Reagents: Methanol
3.1 Reagents: Hydrogen Catalysts: Palladium dihydroxide Solvents: Methanol ,  Tetrahydrofuran
3.2 Reagents: Hydrochloric acid Solvents: Ethanol
3.3 Reagents: Ammonium hydroxide
3.4 Reagents: Dowex 50W Solvents: Water
Reference
Asymmetric Synthesis of α-Amino Acids by Copper-Catalyzed Conjugate Addition of Grignard Reagents to Optically Active Carbamatoacrylates
Lander, Peter A.; et al, Journal of the American Chemical Society, 1994, 116(18), 8126-32

Production Method 10

Reaction Conditions
1.1 Reagents: Butyllithium Solvents: Diethyl ether ,  Pentane ,  Tetrahydrofuran ,  Hexane
1.2 -
1.3 Reagents: Hydrochloric acid Solvents: Water
2.1 Reagents: Triethylamine Solvents: Dimethylformamide
3.1 Catalysts: Cuprous iodide Solvents: Tetrahydrofuran
3.2 Reagents: Methanol
4.1 Reagents: Hydrogen Catalysts: Palladium dihydroxide Solvents: Methanol ,  Tetrahydrofuran
4.2 Reagents: Hydrochloric acid Solvents: Ethanol
4.3 Reagents: Ammonium hydroxide
4.4 Reagents: Dowex 50W Solvents: Water
Reference
Asymmetric Synthesis of α-Amino Acids by Copper-Catalyzed Conjugate Addition of Grignard Reagents to Optically Active Carbamatoacrylates
Lander, Peter A.; et al, Journal of the American Chemical Society, 1994, 116(18), 8126-32

(2R)-2-amino-4,4-dimethylpentanoic acid Raw materials

(2R)-2-amino-4,4-dimethylpentanoic acid Preparation Products

(2R)-2-amino-4,4-dimethylpentanoic acid Related Literature

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88319-43-1 ((2R)-2-amino-4,4-dimethylpentanoic acid) Related Products

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