Production Method 1

14667-47-1

88312-64-5

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Nitric acid ;  0 °C; 0 °C → rt; 2 h, rt
1.2 Reagents: Sodium carbonate Solvents: Water ;  pH 8, 0 °C

Reference

Rational multistep synthesis of a novel polyfunctionalized benzo[d]thiazole and its thiazolo[5,4-b]pyridine analogue

Hedou, Damien; et al, Tetrahedron, 2014, 70(35), 5541-5549

Production Method 2

14667-47-1

88312-64-5

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Nitric acid Solvents: Water ;  45 min, 0 °C; 19 h, rt; 4 h, 70 °C; 70 °C → 0 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  pH 8

Reference

Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease

Harrison, Justin R.; et al, Journal of Medicinal Chemistry, 2020, 63(6), 3066-3089

Production Method 3

5345-47-1

88312-64-5

Reaction Conditions

1.1 Reagents: Sulfuric acid ;  0 °C; 1.5 h, 60 °C
1.2 Reagents: Sodium carbonate Solvents: Water ;  pH 8, 0 °C
2.1 Reagents: Sulfuric acid ,  Nitric acid ;  0 °C; 0 °C → rt; 2 h, rt
2.2 Reagents: Sodium carbonate Solvents: Water ;  pH 8, 0 °C

Reference

Rational multistep synthesis of a novel polyfunctionalized benzo[d]thiazole and its thiazolo[5,4-b]pyridine analogue

Hedou, Damien; et al, Tetrahedron, 2014, 70(35), 5541-5549

Methyl 2-amino-5-nitronicotinate Raw materials

• 2-aminopyridine-3-carboxylic acid
• methyl 2-aminopyridine-3-carboxylate

Methyl 2-amino-5-nitronicotinate Preparation Products

• Methyl 2-amino-5-nitronicotinate (88312-64-5)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids

• 1078-05-3(4-Nitronicotinic acidn-oxide)
• 6760-14-1(2-amino-5-nitropyridine-3-carboxylic acid)
• 619-50-1(Methyl 4-nitrobenzoate)
• 641-70-3(3-Nitrophthalic anhydride)
• 1955-46-0(Methyl 5-Nitroisophthalate)
• 2047-49-6(5-Nitro Nicotinic Acid)
• 618-95-1(Methyl 3-nitrobenzoate)
• 99-42-3(Methyl 4-hydroxy-3-nitrobenzoate)
• 99-77-4(ethyl-P-nitrobenzoate)
• 88312-65-6(Ethyl 2-amino-5-nitronicotinate)