Production Method 1

1779-49-3

211108-50-8

882033-92-3

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ;  -78 °C; 2 h, -78 °C
1.2 Solvents: Tetrahydrofuran ;  -78 °C; -78 °C → rt; overnight, rt
1.3 Reagents: Water ;  rt

Reference

Synthesis and in vitro characterization of trans- and cis-[18F]-4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]-3-fluoropiperidine-1-carboxylates as new potential PET radiotracer candidates for the NR2B subtype N-methyl-D-aspartate receptor

Koudih, Radouane; et al, European Journal of Medicinal Chemistry, 2012, 53, 408-415

Production Method 2

75-77-4

882033-92-3

Reaction Conditions

1.1 Reagents: Triethylamine
2.1 Reagents: Selectfluor
3.1 Reagents: Butyllithium Solvents: Tetrahydrofuran

Reference

Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model

Barberis, Claude; et al, Bioorganic & Medicinal Chemistry Letters, 2020, 30(23),

Production Method 3

1779-49-3

211108-50-8

882033-92-3

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran

Reference

Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model

Barberis, Claude; et al, Bioorganic & Medicinal Chemistry Letters, 2020, 30(23),

Production Method 4

211108-48-4

882033-92-3

Reaction Conditions

1.1 Reagents: Selectfluor
2.1 Reagents: Butyllithium Solvents: Tetrahydrofuran

Reference

Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model

Barberis, Claude; et al, Bioorganic & Medicinal Chemistry Letters, 2020, 30(23),

tert-butyl 3-fluoro-4-methylidenepiperidine-1-carboxylate Raw materials

• Methyltriphenylphosphonium bromide
• Chlorotrimethylsilane
• Tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate
• tert-Butyl 4-((trimethylsilyl)oxy)-5,6-dihydropyridine-1(2H)-carboxylate

tert-butyl 3-fluoro-4-methylidenepiperidine-1-carboxylate Preparation Products

• tert-butyl 3-fluoro-4-methylidenepiperidine-1-carboxylate (882033-92-3)

• 1. Excellent kinetics of single-phase Gd-doped ceria fuel electrodes in solid oxide cells?
  Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431
• 2. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 3. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
  Analyst, 1991,116, 1125-1130
• 4. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
• 5. Dissociation of large gaseous serine clusters produces abundant protonated serine octamer
  Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidinecarboxylic acids and derivatives Piperidinecarboxylic acids

• 1068560-26-8(Tert-butyl 3-fluoropiperidine-1-carboxylate)
• 1260612-08-5(tert-butyl (3R,4R)-4-amino-3-fluoropiperidine-1-carboxylate)
• 907544-16-5(tert-butyl trans-4-amino-3-fluoropiperidine-1-carboxylate)
• 873221-81-9((3R)-3-Fluoropiperidine-1-carboxylic acid tert-butyl ester)
• 1196712-26-1(1-Piperidinecarboxylic acid, 5-fluoro-3,3-dimethyl-, 1,1-dimethylethyl ester)
• 907544-20-1(tert-butyl (3S,4R)-4-amino-3-fluoropiperidine-1-carboxylate)
• 577691-56-6(tert-butyl cis-4-amino-3-fluoropiperidine-1-carboxylate)
• 1219832-36-6(tert-butyl 3-(aminomethyl)-3-fluoropiperidine-1-carboxylate)
• 934536-10-4(tert-Butyl 4-amino-3-fluoropiperidine-1-carboxylate)
• 1228185-45-2(tert-butyl (3S,4S)-4-amino-3-fluoropiperidine-1-carboxylate)