Production Method 1

882-09-7

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Acetone ,  Water ;  rt; 0.5 h, reflux
1.2 Solvents: Acetone ;  reflux; 3.5 h, reflux

Reference

Synthesis and preliminary antihyperlipidaemic activities evaluation of andrographolide derivatives

Wang, Bin; et al, Medicinal Chemistry, 2012, 8(2), 293-298

Production Method 2

57-15-8

882-09-7

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Acetone

Reference

ipso Nitration in p-halophenyl ethers

Clewley, Robin G.; et al, Canadian Journal of Chemistry, 1989, 67(9), 1472-9

Production Method 3

594-58-1

882-09-7

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  neutralized, rt
1.2 Reagents: Sodium hydroxide Solvents: Water ;  rt; rt → 80 °C; 3 h, 75 - 80 °C

Reference

Novel Shikonin Derivatives Targeting Tubulin as Anticancer Agents

Guo, Jing; et al, Chemical Biology & Drug Design, 2014, 84(5), 603-615

Production Method 4

55162-41-9

882-09-7

Reaction Conditions

1.1 Reagents: Sodium hydroxide ,  Hydrochloric acid Solvents: Water ;  50 °C

Reference

Optimization of clofibrate with O-desmethyl anetholtrithione lead to a novel hypolipidemia compound with hepatoprotective effect

Liu, Haitao; et al, Bioorganic & Medicinal Chemistry Letters, 2022, 72,

Production Method 5

64416-88-2

882-09-7

Reaction Conditions

Reference

Late-Stageβ-C(sp3)-H Deuteration of Carboxylic Acids

Uttry, Alexander; et al, Journal of the American Chemical Society, 2021, 143(29), 10895-10901

Production Method 6

23877-12-5

882-09-7

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Sulfuric acid magnesium salt (1:1) ;  overnight, rt → 100 °C
2.1 Solvents: Dichloromethane ,  Trifluoroacetic acid ;  5 h, rt

Reference

Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers

Sijbesma, Eline; et al, Journal of the American Chemical Society, 2019, 141(8), 3524-3531

Production Method 7

31637-97-5

882-09-7

107-21-1

59-67-6

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Methanol ,  Water ;  20 min, 75 °C

Reference

Substituted tertiary phosphine Ru(II) organometallics: Catalytic utility on the hydrolysis of etofibrate in pharmaceuticals

Reddy, P. Muralidhar; et al, Spectrochimica Acta, 2008, (5), 1231-1237

Production Method 8

882-09-7

Reaction Conditions

1.1 Reagents: Sodium hydroxide Catalysts: Benzyltriethylammonium chloride ,  Polyethylene glycol Solvents: Water

Reference

Synthesis of clofibric acid under PTC condition

Chen, Yi-Ping, Zhongguo Yiyao Gongye Zazhi, 2000, 31(6), 281-282

Production Method 9

882-09-7

Reaction Conditions

1.1 Catalysts: Potassium hydroxide ,  Trioctylmethylammonium chloride ,  Polyethylene glycol Solvents: Acetone ,  Water ;  32 - 35 °C; 20 min, 32 - 35 °C
1.2 35 °C → reflux; 50 min, reflux
1.3 Reagents: Hydrochloric acid Solvents: Water ;  pH 2, reflux; reflux → rt; 1.5 h, rt

Reference

Improvement of synthesis process for p-Chlorophenoxyisobutyric acid

Fang, Hui-zhen; et al, Guangzhou Huagong, 2010, 38(7), 99-100

Production Method 10

637-07-0

882-09-7

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Methanol ,  Tetrahydrofuran ,  Water ;  3 h, 60 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  acidified, rt

Reference

Design, Synthesis of Novel, Potent, Selective, Orally Bioavailable Adenosine A2A Receptor Antagonists and Their Biological Evaluation

Basu, Sujay ; et al, Journal of Medicinal Chemistry, 2017, 60(2), 681-694

Production Method 11

637-07-0

882-09-7

Reaction Conditions

1.1 Reagents: Sodium hydroxide ;  5 h, 50 °C; 50 °C → rt
1.2 Reagents: Hydrochloric acid ;  acidified

Reference

The combination of sesamol and clofibric acid moieties leads to a novel potent hypolipidemic agent with antioxidant, anti-inflammatory and hepatoprotective activity

Xie, Yundong; et al, Bioorganic & Medicinal Chemistry Letters, 2021, 44,

Production Method 12

467254-02-0

882-09-7

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ,  Tetrahydrofuran ;  rt; 30 min, 50 °C; 50 °C → rt
1.2 Catalysts: Tetrabutylammonium iodide ,  Potassium iodide ;  rt; 12 h, 50 °C; cooled
1.3 Reagents: Sodium hydroxide Solvents: Water ;  12 h, rt
1.4 Reagents: Hydrochloric acid Solvents: Water ;  pH 2 - 3, rt

Reference

Liquid-phase synthesis of 2-methyl-2-aryloxypropanoic acid derivatives from poly(ethylene glycol)-supported 2-bromo-2-methylpropanoate

Huang, Bin; et al, Journal of the Chinese Chemical Society (Taipei, 2007, 54(3), 575-578

Production Method 13

2052-01-9

882-09-7

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Methyl ethyl ketone ;  0.5 h, rt → 50 °C; 1 h, 50 °C
1.2 Solvents: Methyl ethyl ketone ;  1 h, 50 °C; 1.5 h, 50 °C

Reference

Improved method for the synthesis of 2-methyl-2-aryloxypropanoic acid derivatives

Davis, Roman D.; et al, Synthesis, 2004, (12), 1959-1962

Production Method 14

2052-01-9

882-09-7

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Methyl ethyl ketone ;  rt → 50 °C; 2 h, 50 °C
1.2 Solvents: Methyl ethyl ketone ;  8 h, 50 °C; 3 h, 50 °C
1.3 Reagents: Water ;  overnight, rt
1.4 Reagents: Sodium bisulfite ,  Hydrochloric acid Solvents: Water ;  overnight, pH 6.5, rt
1.5 Reagents: Hydrochloric acid Solvents: Water ;  pH 1.6

Reference

Pd(II)-Catalyzed ortho- or meta-C-H Olefination of Phenol Derivatives

Dai, Hui-Xiong; et al, Journal of the American Chemical Society, 2013, 135(20), 7567-7571

Production Method 15

882-09-7

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  12 h, 70 °C
1.2 Reagents: Sodium hydroxide Solvents: Methanol ,  Tetrahydrofuran ,  Water ;  16 h, 60 °C; 0 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ;  acidified, 0 °C

Reference

Direct synthesis and applications of solid silylzinc reagents

Chandrasekaran, Revathi; et al, ChemRxiv, 2021, 1, 1-10

Production Method 16

882-09-7

Reaction Conditions

1.1 Solvents: Dichloromethane ,  Trifluoroacetic acid ;  5 h, rt

Reference

Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers

Sijbesma, Eline; et al, Journal of the American Chemical Society, 2019, 141(8), 3524-3531

Production Method 17

7314-47-8

882-09-7

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Water ;  pH 1

Reference

Selective radical cascade (4+2) annulation with olefins towards the synthesis of chroman derivatives via organo-photoredox catalysis

Guan, Zhipeng; et al, Chemical Science, 2022, 13(21), 6316-6321

Production Method 18

25322-68-3

2052-01-9

882-09-7

Reaction Conditions

1.1 Reagents: Dicyclohexylcarbodiimide Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ;  24 h, rt
2.1 Reagents: Sodium hydride Solvents: Dimethylformamide ,  Tetrahydrofuran ;  rt; 30 min, 50 °C; 50 °C → rt
2.2 Catalysts: Tetrabutylammonium iodide ,  Potassium iodide ;  rt; 12 h, 50 °C; cooled
2.3 Reagents: Sodium hydroxide Solvents: Water ;  12 h, rt
2.4 Reagents: Hydrochloric acid Solvents: Water ;  pH 2 - 3, rt

Reference

Liquid-phase synthesis of 2-methyl-2-aryloxypropanoic acid derivatives from poly(ethylene glycol)-supported 2-bromo-2-methylpropanoate

Huang, Bin; et al, Journal of the Chinese Chemical Society (Taipei, 2007, 54(3), 575-578

Clofibric acid Raw materials

• Polyethylene Glycol
• Poly(ethylene glycol) bis(2-bromoisobutyrate)
• Propanoic acid,2-(4-chlorophenoxy)-2-methyl-, methyl ester
• Etofibrate
• 2-Bromoisobutyric Acid
• 2-Chloro-2-methylpropanoic acid
• Chlorobutanol
• tert-Butyl 2-bromo-2-methylpropanoate
• Clofibrate
• Propanoic acid,2-(4-chlorophenoxy)-2-methyl-, sodium salt (1:1)
• 2-(4-Chlorophenoxy)-2-methyl-1-methylethyl Ester Propanoic Acid

Clofibric acid Preparation Products

• Ethylene Glycol, Dehydrated (107-21-1)
• Clofibric acid (882-09-7)
• Niacin (59-67-6)

• 1. An insight into the origin of room-temperature ferromagnetism in SnO2 and Mn-doped SnO2 quantum dots: an experimental and DFT approach?
  Dhamodaran Manikandan,S. Amirthapandian,I. S. Zhidkov,A. I. Kukharenko,S. O. Cholakh,Ramaswamy Murugan Phys. Chem. Chem. Phys., 2018,20, 6500-6514
• 2. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699
• 3. An assessment of strategies for the development of solid-state adsorbents for vehicular hydrogen storage
  Mark D. Allendorf,Alauddin Ahmed,Tom Autrey,Jeffrey Camp,Eun Seon Cho,Maciej Haranczyk,Abhi Karkamkar,Di-Jia Liu,Katie R. Meihaus,Iffat H. Nayyar,Roman Nazarov,Donald J. Siegel,Vitalie Stavila,Jeffrey J. Urban,Srimukh Prasad Veccham,Brandon C. Wood Energy Environ. Sci., 2018,11, 2784-2812
• 4. An atlas of endohedral Sc2S cluster fullerenes?
  Li-Hua Gan,Rui Wu,Jian-Lei Tian,Patrick W. Fowler Phys. Chem. Chem. Phys., 2017,19, 419-425
• 5. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenoxyacetic acid derivatives

• 26723-02-4(Propanoic acid,2-(4-chlorophenoxy)-2-methyl-, potassium salt (1:1))
• 24215-47-2(alpha-(p-Chlorophenoxy)isobutyric acid, (2-hydroxyethylamino) ester)
• 39087-48-4(Propanoic acid,2-(4-chlorophenoxy)-2-methyl-, calcium salt (2:1))
• 1914-66-5(2-(2,4-Dichlorophenoxy)-2-methylpropanoic acid)
• 14496-66-3(Propionic acid,2-(p-chlorophenoxy)-2-methyl-, propylene ester (8CI))
• 17413-79-5(2-(2-Chlorophenoxy)-2-methylpropanoic acid)
• 14496-63-0(Propionic acid,2-(p-chlorophenoxy)-2-methyl-, ethylene ester (8CI))
• 14613-30-0(Propanoic acid,2-(4-chlorophenoxy)-2-methyl-, magnesium salt (2:1))
• 3307-39-9(2-(4-Chlorophenoxy)propanoic acid)
• 637-07-0(Clofibrate)