Production Method 1

1611-92-3

4885-02-3

88174-23-6

1427565-04-5

Reaction Conditions

1.1 Catalysts: Silver triflate Solvents: Dichloromethane ;  -78 °C; 1.5 h, rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  30 min, rt

Reference

A Direct and Mild Formylation Method for Substituted Benzenes Utilizing Dichloromethyl Methyl Ether-Silver Trifluoromethanesulfonate

Ohsawa, Kosuke; et al, Journal of Organic Chemistry, 2013, 78(7), 3438-3444

Production Method 2

1611-92-3

88174-23-6

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ;  30 min, -75 °C
1.2 30 min, -70 °C
1.3 Reagents: Sulfuric acid Solvents: Water ;  rt

Reference

Regiospecific Metalation of Oligobromobenzenes

Lulinski, Sergiusz; et al, Journal of Organic Chemistry, 2003, 68(13), 5384-5387

Production Method 3

104-87-0

88174-23-6

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Catalysts: 2-Trifluoromethyl-4-chloroaniline ,  Palladium diacetate Solvents: Trifluoroacetic acid ,  1,2-Dichloroethane ;  24 h, 60 °C

Reference

Palladium-catalyzed ortho-C(sp2)-H bromination of benzaldehydes via a monodentate transient directing group strategy

Yong, Qiyun; et al, Tetrahedron Letters, 2019, 60(46),

2,6-Dibromo-4-methylbenzaldehyde Raw materials

• 4-Methylbenzaldehyde
• 1,3-dibromo-5-methylbenzene
• 1,1-Dichlorodimethyl ether

2,6-Dibromo-4-methylbenzaldehyde Preparation Products

• 2,4-Dibromo-6-methylbenzaldehyde (1427565-04-5)
• 2,6-Dibromo-4-methylbenzaldehyde (88174-23-6)

• 1. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
• 2. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
  Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
• 3. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 4. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
  Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043
• 5. Acetylcholinesterase amperometric detection system based on a cobalt(II) tetraphenylporphyrin-modified electrode
  Analyst, 1996,121, 1123-1126

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoyl derivatives

• 90221-55-9(2-Bromo-5-methylbenzaldehyde)
• 67713-23-9(2,6-Dibromobenzaldehyde)
• 52698-81-4(Benzaldehyde, bromo-)
• 74553-29-0(2,5-Dibromobenzaldehyde)
• 6630-33-7(2-Bromobenzaldehyde)
• 5629-98-1(2,4-Dibromobenzaldehyde)
• 63525-48-4(2,5-Dibromoterephthalaldehyde)
• 824-54-4(2-Bromo-4-methylbenzaldehyde)
• 36276-24-1(3-Bromo-4-methylbenzaldehyde)
• 79839-49-9(2-bromobenzene-1,3-dicarbaldehyde)