Production Method 1

334-48-5

88170-22-3

Reaction Conditions

1.1 Reagents: Water-d2 Catalysts: Platinum Solvents: Isopropanol ;  24 h, 120 °C; 120 °C → rt
1.2 Reagents: Sodium hydroxide ;  24 h, 70 °C; 70 °C → rt
1.3 Reagents: Hydrochloric acid Solvents: Water ;  < pH 2, rt

Reference

Mild and Direct Multiple Deuterium-Labeling of Saturated Fatty Acids

Yamada, Tsuyoshi; et al, Advanced Synthesis & Catalysis, 2016, 358(20), 3277-3282

Production Method 2

334-48-5

88170-22-3

Reaction Conditions

1.1 Reagents: Sodium hydroxide ,  Water-d2 Catalysts: Platinum ;  9 d, rt → 220 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 2

Reference

Synthesis of Deuterated and Protiated Triacylglycerides by Using 1,1'-Carbonyldiimidazole Activated Fatty Acids

Schwarzer, Kuno; et al, European Journal of Organic Chemistry, 2023, 26(40),

Decanoic acid-d19 Raw materials

• Decanoic acid

Decanoic acid-d19 Preparation Products

• Decanoic acid-d19 (88170-22-3)

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• 2. An approach to biodegradable star polymeric architectures using disulfide coupling?
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• 4. An assay for the enzyme N-acetyl-β-d-glucosaminidase (NAGase) based on electrochemical detection using screen-printed carbon electrodes (SPCEs)
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• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Fatty Acyls Medium-chain fatty acids
• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Fatty Acyls Fatty acids and conjugates Medium-chain fatty acids

Professional Introduction to Decanoic acid-d19 (CAS No. 88170-22-3)

Decanoic acid-d19, a deuterated derivative of nonanoic acid, is a compound of significant interest in the field of chemical and pharmaceutical research. With the CAS number 88170-22-3, this molecule has garnered attention due to its unique isotopic properties and potential applications in various scientific domains. The introduction of deuterium atoms into the decanoic acid molecule not only modifies its physical and chemical characteristics but also opens up new avenues for study in areas such as metabolic labeling, drug metabolism, and analytical chemistry.

The structure of Decanoic acid-d19 consists of a nonane backbone with nine carbon atoms, where one or more hydrogen atoms are replaced by deuterium (D). This substitution imparts distinct spectroscopic properties, making it an invaluable tool for researchers seeking high-resolution analytical techniques. Specifically, the deuterated version exhibits a shifted nuclear magnetic resonance (NMR) spectrum, which allows for better resolution and differentiation in complex mixtures. This feature is particularly useful in the study of biological systems where subtle differences in molecular environments can provide critical insights.

In recent years, Decanoic acid-d19 has found applications in the field of metabolomics. Metabolomics involves the comprehensive analysis of small molecules (metabolites) within a biological system, providing a snapshot of cellular processes. The use of deuterated compounds like Decanoic acid-d19 allows researchers to track metabolic pathways with high precision. For instance, studies have demonstrated its utility in monitoring the incorporation of deuterated fatty acids into triglycerides and other lipids, thereby offering insights into lipid metabolism and its regulation.

Furthermore, Decanoic acid-d19 has been employed in the development and validation of mass spectrometry methods for drug metabolism studies. The high mass accuracy provided by deuterated compounds helps in distinguishing between parent drugs and their metabolites, which is crucial for understanding drug efficacy and safety profiles. Recent research has highlighted its role in studying the metabolic fate of novel drug candidates, particularly those with complex structures that undergo multiple transformations within the body.

The pharmaceutical industry has also explored Decanoic acid-d19 as a potential intermediate in the synthesis of more complex molecules. Its stable structure and predictable reactivity make it an attractive candidate for use in multi-step synthetic routes. For example, researchers have utilized Decanoic acid-d19 to develop labeled probes for imaging studies, where its isotopic properties enhance signal detection without interfering with biological processes. This application is particularly relevant in preclinical research aimed at evaluating new therapeutic agents.

From an analytical chemistry perspective, Decanoic acid-d19 serves as an internal standard or reference compound in various analytical techniques. Its well-characterized properties enable researchers to calibrate instruments and validate methods with high confidence. This is especially important in regulatory settings where accurate quantification of substances is essential for compliance with safety and quality standards. The compound's stability under different conditions further enhances its utility as a reliable reference material.

The environmental science sector has also shown interest in Decanoic acid-d19 due to its potential use as a tracer molecule. Studies have investigated its behavior in aquatic systems, where it can help track the movement and degradation of organic compounds. This application is particularly valuable for assessing environmental impact and developing strategies for pollution control. The ability to detect trace amounts of Decanoic acid-d19 using advanced analytical techniques underscores its importance in environmental monitoring.

In conclusion, Decanoic acid-d19 (CAS No. 88170-22-3) is a versatile compound with broad applications across multiple scientific disciplines. Its unique isotopic properties make it an invaluable tool for metabolic studies, drug development, synthetic chemistry, and environmental analysis. As research continues to uncover new uses for deuterated compounds, Decanoic acid-d19 is poised to play an increasingly significant role in advancing scientific understanding and innovation.

• 505-48-6(Suberic acid)
• 110-94-1(pentanedioic acid)
• 111-20-6(Sebacic acid)
• 112-37-8(Undecanoic acid)
• 143-07-7(Lauric acid)
• 57-11-4(octadecanoic acid)
• 110-15-6(butanedioic acid)
• 111-16-0(Pimelic acid)
• 124-07-2(Octanoic acid)
• 57-10-3(Palmitic acid)