Cas no 88150-46-3 (2-(2-Azidoethoxy)methyl-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine)

2-(2-Azidoethoxy)methyl-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine structure
88150-46-3 structure
Product Name:2-(2-Azidoethoxy)methyl-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine
CAS No:88150-46-3
MF:C20H23ClN4O5
MW:434.873423814774
CID:643078
Update Time:2023-12-05

2-(2-Azidoethoxy)methyl-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine Chemical and Physical Properties

Names and Identifiers

    • 3,5-Pyridinedicarboxylic acid,2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-,3-ethyl 5-methyl ester
    • 2-[(2-Azidoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine
    • 2-[(2-Azidoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydr
    • 3,5-Pyridinedicarboxylic acid,2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methy...
    • 3-O-ethyl 5-O-methyl 2-(2-azidoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
    • 3-Ethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate (ACI)
    • 2-(2-Azido-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester
    • 2-[(2-Azidoethoxy)methyl]-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine
    • 3-Ethyl 5-methyl 2-((2-azidoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
    • 2-(2-Azidoethoxy)methyl-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine
    • Inchi： 1S/C20H23ClN4O5/c1-4-30-20(27)18-15(11-29-10-9-23-25-22)24-12(2)16(19(26)28-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,24H,4,9-11H2,1-3H3
    • InChI Key： ORRUHLWSVNVRGO-UHFFFAOYSA-N
    • SMILES： [N-]=[N+]=NCCOCC1=C(C(OCC)=O)C(C2C(Cl)=CC=CC=2)C(C(OC)=O)=C(C)N1

Computed Properties

  • Exact Mass: 434.13600

Experimental Properties

  • Melting Point: 143-145°C
  • PSA: 123.61000
  • LogP: 3.39946

2-(2-Azidoethoxy)methyl-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
TRC
A848950-5mg
2-[(2-Azidoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine
 88150-46-3
5mg
 $ 115.00 2023-04-19
TRC
A848950-10mg
2-[(2-Azidoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine
 88150-46-3
10mg
 $ 150.00 2023-04-19
TRC
A848950-25mg
2-[(2-Azidoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine
 88150-46-3
25mg
 $ 385.00 2023-04-19
TRC
A848950-50mg
2-[(2-Azidoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine
 88150-46-3
50mg
 $ 770.00 2023-04-19
TRC
A848950-100mg
2-[(2-Azidoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine
 88150-46-3
100mg
 $ 1126.00 2023-04-19
A2B Chem LLC
AD88490-25mg
2-[(2-Azidoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine
 88150-46-3
25mg
 $495.00 2024-04-19
A2B Chem LLC
AD88490-100mg
2-[(2-Azidoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine
 88150-46-3
100mg
 $1216.00 2024-04-19

2-(2-Azidoethoxy)methyl-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Pyridinium tribromide Solvents: Dichloromethane ;  0 °C
1.2 Reagents: Sodium hydride Solvents: Diethyl ether ;  0 °C
Reference
Synthesis of 1,4-dihydropyridine using microwave-assisted aza-Diels-Alder reaction and its application to amlodipine
Lee, Youn A.; et al, Journal of Industrial and Engineering Chemistry (Amsterdam, 2011, 17(3), 401-403

Production Method 2

Reaction Conditions
Reference
A novel method for Knoevenagel condensation
, Taiwan, , ,

Production Method 3

Reaction Conditions
1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran
1.2 -
2.1 Reagents: Ammonium acetate Solvents: Ethanol
2.2 -
Reference
Long-acting dihydropyridine calcium antagonists. 1. 2-Alkoxymethyl derivatives incorporating basic substituents
Arrowsmith, John E.; et al, Journal of Medicinal Chemistry, 1986, 29(9), 1696-702

Production Method 4

Reaction Conditions
Reference
A novel method for Knoevenagel condensation
, Taiwan, , ,

Production Method 5

Reaction Conditions
1.1 Reagents: Formic acid Catalysts: Palladium Solvents: Methanol ;  reflux
2.1 Reagents: Pyridinium tribromide Solvents: Dichloromethane ;  0 °C
2.2 Reagents: Sodium hydride Solvents: Diethyl ether ;  0 °C
Reference
Synthesis of 1,4-dihydropyridine using microwave-assisted aza-Diels-Alder reaction and its application to amlodipine
Lee, Youn A.; et al, Journal of Industrial and Engineering Chemistry (Amsterdam, 2011, 17(3), 401-403

Production Method 6

Reaction Conditions
1.1 Reagents: Formic acid Catalysts: Palladium Solvents: Methanol
2.1 -
2.2 -
Reference
Synthesis of amlodipine using aza Diels-Alder reaction
Kim, Seok-Chan; et al, Bulletin of the Korean Chemical Society, 2002, 23(1), 143-144

Production Method 7

Reaction Conditions
Reference
A novel method for Knoevenagel condensation
, Taiwan, , ,

Production Method 8

Reaction Conditions
1.1 Reagents: Potassium bicarbonate ,  Oxygen ,  Sulfuryl azide fluoride Solvents: Dimethylformamide ,  tert-Butyl methyl ether ,  Water ;  5 min, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 1, rt
Reference
Modular click chemistry libraries for functional screens using a diazotizing reagent
Meng, Genyi; et al, Nature (London, 2019, 574(7776), 86-89

Production Method 9

Reaction Conditions
Reference
Synthesis of amlodipine using aza Diels-Alder reaction
Kim, Seok-Chan; et al, Bulletin of the Korean Chemical Society, 2002, 23(1), 143-144

Production Method 10

Reaction Conditions
1.1 Reagents: Ammonium acetate Solvents: Ethanol
1.2 -
Reference
Long-acting dihydropyridine calcium antagonists. 1. 2-Alkoxymethyl derivatives incorporating basic substituents
Arrowsmith, John E.; et al, Journal of Medicinal Chemistry, 1986, 29(9), 1696-702

Production Method 11

Reaction Conditions
Reference
A novel method for Knoevenagel condensation
, Taiwan, , ,

Production Method 12

Reaction Conditions
1.1 Reagents: Sulfuric acid magnesium salt (1:1) ;  40 s, 70 °C
1.2 15 min, 130 °C
2.1 Reagents: Formic acid Catalysts: Palladium Solvents: Methanol ;  reflux
3.1 Reagents: Pyridinium tribromide Solvents: Dichloromethane ;  0 °C
3.2 Reagents: Sodium hydride Solvents: Diethyl ether ;  0 °C
Reference
Synthesis of 1,4-dihydropyridine using microwave-assisted aza-Diels-Alder reaction and its application to amlodipine
Lee, Youn A.; et al, Journal of Industrial and Engineering Chemistry (Amsterdam, 2011, 17(3), 401-403

Production Method 13

Reaction Conditions
1.1 Reagents: Sulfuric acid magnesium salt (1:1) Solvents: Toluene
2.1 Reagents: Formic acid Catalysts: Palladium Solvents: Methanol
3.1 -
3.2 -
Reference
Synthesis of amlodipine using aza Diels-Alder reaction
Kim, Seok-Chan; et al, Bulletin of the Korean Chemical Society, 2002, 23(1), 143-144

Production Method 14

Reaction Conditions
1.1 heated
2.1 Reagents: Sulfuric acid magnesium salt (1:1) ;  40 s, 70 °C
2.2 15 min, 130 °C
3.1 Reagents: Formic acid Catalysts: Palladium Solvents: Methanol ;  reflux
4.1 Reagents: Pyridinium tribromide Solvents: Dichloromethane ;  0 °C
4.2 Reagents: Sodium hydride Solvents: Diethyl ether ;  0 °C
Reference
Synthesis of 1,4-dihydropyridine using microwave-assisted aza-Diels-Alder reaction and its application to amlodipine
Lee, Youn A.; et al, Journal of Industrial and Engineering Chemistry (Amsterdam, 2011, 17(3), 401-403

2-(2-Azidoethoxy)methyl-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine Raw materials

2-(2-Azidoethoxy)methyl-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine Preparation Products

2-(2-Azidoethoxy)methyl-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine Related Literature

Related Categories

88150-46-3 (2-(2-Azidoethoxy)methyl-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl)-6-methyl-1,4-dihydropyridine) Related Products

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