Production Method 1

155396-71-7

88000-67-3

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: Dimethylformamide ;  3 h, rt
1.2 Reagents: Potassium peroxymonosulfate sulfate (2KHSO5.KHSO4.K2SO4) ;  1 h, rt

Reference

Direct Aldimine Oxidative Reaction: A General Approach toward Amides

Liu, Qing-Peng; et al, Asian Journal of Organic Chemistry, 2023, 12(3),

Production Method 2

4248-19-5

93-58-3

88000-67-3

Reaction Conditions

1.1 Reagents: Lithium tert-butoxide Solvents: Tetrahydrofuran ;  10 min, < -20 °C; 10 min, < -20 °C; 18 h, rt

Reference

Metal-free stereoselective synthesis of (E)- and (Z)-N-monosubstituted β-aminoacrylates via condensation reactions of carbamates

Pollack, Scott R. ; et al, Journal of Organic Chemistry, 2021, 86(17), 11748-11762

Production Method 3

271600-36-3

88000-67-3

Reaction Conditions

1.1 Reagents: Sodium cyanide ,  Potassium carbonate Solvents: Dimethylformamide ;  60 °C
1.2 Reagents: Sodium cyanide Solvents: Dimethylformamide ;  120 °C
1.3 Reagents: Sodium hydroxide Solvents: Water ;  10 min, rt

Reference

Formation of Amides from Imines via Cyanide-Mediated Metal-Free Aerobic Oxidation

Seo, Hong-Ahn; et al, Journal of Organic Chemistry, 2015, 80(24), 11993-11998

Production Method 4

271600-36-3

88000-67-3

Reaction Conditions

1.1 Reagents: 1,1,3,3-Tetramethylguanidine ,  m-Chloroperbenzoic acid Solvents: Dichloromethane ;  rt; 6 h, rt

Reference

Metal-Free Synthesis of Imido Derivatives by Direct Oxidation of α-Amido Sulfones

Martinelli, Fabio; et al, European Journal of Organic Chemistry, 2010, (26), 5085-5089

Production Method 5

42116-44-9

88000-67-3

Reaction Conditions

1.1 Catalysts: Silica

Reference

Oxidation of organic compounds by zinc permanganate

Wolfe, Saul; et al, Journal of the American Chemical Society, 1983, 105(26), 7755-7

Production Method 6

24424-99-5

55-21-0

88000-67-3

Reaction Conditions

1.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: Acetonitrile ;  15 h, rt

Reference

Zn-Catalyzed tert-Butyl Nicotinate-Directed Amide Cleavage as a Biomimic of Metallo-Exopeptidase Activity

Wybon, Clarence C. D. ; et al, ACS Catalysis, 2018, 8(1), 203-218

Production Method 7

150884-50-7

88000-67-3

Reaction Conditions

1.1 Reagents: Sodium cyanide Solvents: Dimethylformamide ;  120 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ;  10 min, rt

Reference

Formation of Amides from Imines via Cyanide-Mediated Metal-Free Aerobic Oxidation

Seo, Hong-Ahn; et al, Journal of Organic Chemistry, 2015, 80(24), 11993-11998

Production Method 8

4248-19-5

88000-67-3

Reaction Conditions

1.1 Reagents: Trichloroisocyanuric acid Solvents: Methanol ;  1 h, rt
1.2 Reagents: Sodium hydroxide Solvents: Methanol ;  rt → 0 °C; 30 min, rt
2.1 Solvents: Acetonitrile ;  3 h, 30 °C

Reference

Controlled Relay Process to Access N-Centered Radicals for Catalyst-free Amidation of Aldehydes under Visible Light

Lee, Wongyu; et al, Chem, 2021, 7(2), 495-508

Production Method 9

88000-67-3

Reaction Conditions

1.1 Solvents: Acetonitrile ;  12 h, 30 °C
2.1 Reagents: Trichloroisocyanuric acid Solvents: Methanol ;  1 h, rt
2.2 Reagents: Sodium hydroxide Solvents: Methanol ;  rt → 0 °C; 30 min, rt
3.1 Solvents: Acetonitrile ;  3 h, 30 °C

Reference

Controlled Relay Process to Access N-Centered Radicals for Catalyst-free Amidation of Aldehydes under Visible Light

Lee, Wongyu; et al, Chem, 2021, 7(2), 495-508

Production Method 10

769069-45-6

88000-67-3

Reaction Conditions

1.1 Solvents: Acetonitrile ;  3 h, 30 °C
2.1 Reagents: Trichloroisocyanuric acid Solvents: Methanol ;  1 h, rt
2.2 Reagents: Sodium hydroxide Solvents: Methanol ;  rt → 0 °C; 30 min, rt
3.1 Catalysts: Triethylborane ,  Benzoyl chloride Solvents: Acetonitrile ;  6 h, 30 °C

Reference

Controlled Relay Process to Access N-Centered Radicals for Catalyst-free Amidation of Aldehydes under Visible Light

Lee, Wongyu; et al, Chem, 2021, 7(2), 495-508

Production Method 11

73210-14-7

104-87-0

98-88-4

88000-67-3

874-60-2

Reaction Conditions

1.1 Solvents: Acetonitrile ;  3 h, 30 °C

Reference

Controlled Relay Process to Access N-Centered Radicals for Catalyst-free Amidation of Aldehydes under Visible Light

Lee, Wongyu; et al, Chem, 2021, 7(2), 495-508

Production Method 12

3601-66-9

88000-67-3

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Cupric acetate ,  2,9-Dimethyl-1,10-phenanthroline Solvents: Acetonitrile ,  Water ;  24 h, 30 °C

Reference

Copper(II)-photocatalyzed decarboxylative oxygenation of carboxylic acids

Reichle, Alexander; et al, Chemical Communications (Cambridge, 2022, 58(28), 4456-4459

Production Method 13

3601-66-9

88000-67-3

Reaction Conditions

1.1 Reagents: Cesium carbonate ,  Oxygen Catalysts: Iridium(1+), [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-κN1,κN1′]bis[3,5-diflu… Solvents: Dichloromethane ;  rt → 40 °C; 40 h, 40 °C

Reference

Decarboxylative Oxidation of Carboxylic Acids Using Photocatalysis and Copper Catalysis

Zaman, Muhammad Kashif; et al, Synlett, 2023, 34(17), 2029-2033

Production Method 14

3601-66-9

88000-67-3

Reaction Conditions

1.1 Reagents: Cesium carbonate ,  Oxygen ,  Sodium borohydride Catalysts: Iridium(1+), [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-κN1,κN1′]bis[3,5-diflu… Solvents: Dichloromethane ;  rt → 40 °C; 40 h, 40 °C
1.2 Reagents: Water

Reference

A General Method for Photocatalytic Decarboxylative Hydroxylation of Carboxylic Acids

Khan, Shah Nawaz; et al, Journal of Organic Chemistry, 2020, 85(7), 5019-5026

Production Method 15

73210-14-7

100-52-7

88000-67-3

Reaction Conditions

1.1 Solvents: Acetonitrile ;  3 h, 30 °C

Reference

Controlled Relay Process to Access N-Centered Radicals for Catalyst-free Amidation of Aldehydes under Visible Light

Lee, Wongyu; et al, Chem, 2021, 7(2), 495-508

Production Method 16

4248-19-5

93-58-3

88000-67-3

Reaction Conditions

1.1 Reagents: Lithium tert-butoxide Solvents: Tetrahydrofuran ;  -78 °C; overnight, -78 °C → rt
1.2 Reagents: Hydrochloric acid ,  Ammonium chloride Solvents: Water ;  < pH 4, rt

Reference

Cooperative carbene photocatalysis for β-amino ester synthesis

Tanaka, Nao; et al, ChemRxiv, 2023, 1, 1-8

Production Method 17

55-21-0

88000-67-3

Reaction Conditions

1.1 Solvents: 1,2-Dichloroethane ;  0 °C; 0 °C → 60 °C; 1 h, 60 °C; 60 °C → 0 °C
1.2 Solvents: 1,2-Dichloroethane ;  2 h, 0 °C
1.3 Reagents: Sodium bicarbonate Solvents: Water ;  0 °C

Reference

Asymmetric Auto-Tandem Catalysis with a Planar-Chiral Ruthenium Complex: Sequential Allylic Amidation and Atom-Transfer Radical Cyclization

Kanbayashi, Naoya; et al, Angewandte Chemie, 2013, 52(18), 4897-4901

Production Method 18

42116-44-9

88000-67-3

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: 2-Chloroanthraquinone Solvents: Ethyl acetate ;  30 h, rt

Reference

2-Chloroanthraquinone-catalyzed aerobic photo-oxidative synthesis of diacylamines from benzylamides

Itoh, Izuho; et al, Tetrahedron Letters, 2014, 55(20), 3160-3162

Production Method 19

42116-44-9

88000-67-3

Reaction Conditions

1.1 Reagents: Sodium periodate ,  Ruthenium dioxide Solvents: Ethyl acetate ,  Water

Reference

A new method for the synthesis of amides from amines: ruthenium tetroxide oxidation of N-protected alkylamines

Tanaka, Kenichi; et al, Chemical & Pharmaceutical Bulletin, 1988, 36(8), 3125-9

Production Method 20

24424-99-5

55-21-0

88000-67-3

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ;  rt → 0 °C; 0 °C; 10 min, 0 °C
1.2 overnight, rt

Reference

A reversible safety-catch method for the hydrogenolysis of N-benzyl moieties

Johnson, David C.; et al, Tetrahedron Letters, 2004, 45(46), 8483-8487

Production Method 21

41840-28-2

88000-67-3

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: 1,4-Dioxane ,  Water
2.1 Reagents: Sodium periodate ,  Ruthenium dioxide Solvents: Ethyl acetate ,  Water

Reference

A new method for the synthesis of amides from amines: ruthenium tetroxide oxidation of N-protected alkylamines

Tanaka, Kenichi; et al, Chemical & Pharmaceutical Bulletin, 1988, 36(8), 3125-9

Production Method 22

769069-45-6

88000-67-3

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Methanol ;  rt → 0 °C; 30 min, 25 °C
2.1 Solvents: Ethyl acetate ;  12 h, 30 °C

Reference

N-Chloro-N-sodio-carbamates as a Practical Amidating Reagent for Scalable and Sustainable Amidation of Aldehydes under Visible Light

Jeon, Hyun Ji; et al, Organic Process Research & Development, 2021, 25(5), 1176-1183

Production Method 23

769069-45-6

88000-67-3

Reaction Conditions

1.1 Reagents: Benzaldehyde Solvents: 2,2,2-Trifluoroethanol ;  12 h, 30 °C
2.1 Reagents: Trichloroisocyanuric acid Solvents: Methanol ;  1 h, rt
2.2 Reagents: Sodium hydroxide Solvents: Methanol ;  rt → 0 °C; 30 min, rt
3.1 Catalysts: Triethylborane ,  Benzoyl chloride Solvents: Acetonitrile ;  6 h, 30 °C

Reference

Controlled Relay Process to Access N-Centered Radicals for Catalyst-free Amidation of Aldehydes under Visible Light

Lee, Wongyu; et al, Chem, 2021, 7(2), 495-508

Production Method 24

769069-45-6

88000-67-3

Reaction Conditions

1.1 Solvents: Acetonitrile ;  3 h, 30 °C
2.1 Reagents: Trichloroisocyanuric acid Solvents: Methanol ;  1 h, rt
2.2 Reagents: Sodium hydroxide Solvents: Methanol ;  rt → 0 °C; 30 min, rt
3.1 Solvents: Acetonitrile ;  3 h, 30 °C

Reference

Controlled Relay Process to Access N-Centered Radicals for Catalyst-free Amidation of Aldehydes under Visible Light

Lee, Wongyu; et al, Chem, 2021, 7(2), 495-508

Production Method 25

100-52-7

2632873-25-5

88000-67-3

98-88-4

Reaction Conditions

1.1 Solvents: Acetonitrile ;  3 h, 30 °C

Reference

Controlled Relay Process to Access N-Centered Radicals for Catalyst-free Amidation of Aldehydes under Visible Light

Lee, Wongyu; et al, Chem, 2021, 7(2), 495-508

Production Method 26

73210-14-7

100-52-7

88000-67-3

4248-19-5

Reaction Conditions

1.1 Solvents: Acetonitrile ;  3 h, 30 °C

Reference

Controlled Relay Process to Access N-Centered Radicals for Catalyst-free Amidation of Aldehydes under Visible Light

Lee, Wongyu; et al, Chem, 2021, 7(2), 495-508

Carbamic acid, benzoyl-, 1,1-dimethylethyl ester Raw materials

• Di-tert-butyl dicarbonate
• Carbamic acid, [phenyl(phenylsulfonyl)methyl]-, 1,1-dimethylethyl ester
• Carbamic acid, (phenylmethyl)-, 1,1-dimethylethyl ester (9CI)
• Boc-DL-Phg-OH
• Benzamide
• Carbamic acid, (phenylmethylene)-, 1,1-dimethylethyl ester
• Carbamic acid, chloro-, 1,1-dimethylethyl ester, sodium salt
• tert-Butyl carbamate
• Methyl benzoate
• 4-Methylbenzaldehyde
• N-[phenyl(toluene-4-sulfonyl)methyl]tert-butoxycarboxyamide
• Carbamic acid, chloro-,1,1-dimethylethyl ester (9CI)
• s-Boc-2-mercapto-4,6-dimethylpyrimidine
• Benzoyl chloride
• Benzaldehyde
• Carbamic acid, N-benzoyl-N-chloro-, 1,1-dimethylethyl ester

Carbamic acid, benzoyl-, 1,1-dimethylethyl ester Preparation Products

• p-Toluoyl chloride (874-60-2)
• tert-Butyl carbamate (4248-19-5)
• Carbamic acid, benzoyl-, 1,1-dimethylethyl ester (88000-67-3)
• Benzoyl chloride (98-88-4)

• 1. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)