Production Method 1

902658-81-5

88-61-9

Reaction Conditions

1.1 Solvents: Trifluoroacetic acid ,  Water ;  24 h, rt → 100 °C

Reference

Divergent C-H Functionalizations Directed by Sulfonamide Pharmacophores: Late-Stage Diversification as a Tool for Drug Discovery

Dai, Hui-Xiong; Stepan, Antonia F.; Plummer, Mark S.; Zhang, Yang-Hui; Yu, Jin-Quan, Journal of the American Chemical Society, 2011, 133(18), 7222-7228

Production Method 2

88-61-9

Reaction Conditions

1.1 Reagents: 1H-Imidazolium, 1,3-disulfo-, chloride (1:1) Solvents: Water ;  3 min, 50 °C

Reference

Regioselective Sulfonation of Aromatic Compounds over 1,3-Disulfonic Acid Imidazolium Chloride under Aqueous Media

Moosavi-Zare, Ahmad Reza; Zolfigol, Mohammad Ali; Noroozizadeh, Ehsan, Synlett, 2016, 27(11), 1682-1684

Production Method 3

81292-90-2

88-61-9

Reaction Conditions

1.1 Reagents: Hydrochloric acid

Reference

Sulfosilylation of aromatic hydrocarbons with trimethylsilyl chlorosulfonate

Hofmann, Karin; Simchen, Gerhard, Liebigs Annalen der Chemie, 1982, (2), 282-97

Production Method 4

88-61-9

Reaction Conditions

1.1 Reagents: Sodium bisulfite Catalysts: Dipyridinium dichromate ;  3.0 min, 2 bar, 100 °C

Reference

Cornforth and Corey-Suggs reagents as efficient catalysts for sulfonation of aromatic and heteroaromatic compounds using NaHSO3 under solvent free and microwave conditions

Fatima, Touheeth; Duguta, Govardhan; Purugula, Venkanna; Yelike, Hemanth Sriram; Kamatala, Chinna Rajanna, Phosphorus, 2020, 195(12), 1001-1006

Production Method 5

88-61-9

Reaction Conditions

1.1 Reagents: Sulfuric acid (silica supported) ;  30 min, 80 °C

Reference

A novel method for sulfonation of aromatic rings with silica sulfuric acid

Hajipour, Abdol R.; Mirjalili, Bi Bi F.; Zarei, Amin; Khazdooz, Leila; Ruoho, A. E., Tetrahedron Letters, 2004, 45(35), 6607-6609

Production Method 6

88-61-9

Reaction Conditions

1.1 Reagents: Sulfuric acid ;  45 min, 25 - 39 °C

Reference

Ultrasound assisted regioselective sulfonation of aromatic compounds with sulfuric acid

Qureshi, Ziyauddin S.; Deshmukh, Krishna M.; Jagtap, Sachin R.; Nandurkar, Nitin S.; Bhanage, Bhalchandra M., Ultrasonics Sonochemistry, 2008, 16(3), 308-311

Production Method 7

31033-06-4

88-61-9

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Sodium borohydride

Reference

Studies of reactions of amines with sulfur trioxide. VI. Thermal reactions of anilinium, dimethylanilinium, and trimethylanilinium salts of butylamidosulfuric acid

Kanetani, Fujio; Yamaguchi, Hachiro, Bulletin of the Chemical Society of Japan, 1981, 54(10), 3048-58

Production Method 8

88-61-9

47318-40-1

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Ethanol

Reference

Reactions of triarylbismuth bis(arenesulfonates)

Sharutin, V. V.; Sharutina, O. K.; Egorova, I. V.; Ettenko, E. N., Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii), 2001, 71(8), 1236-1237

Production Method 9

88-61-9

5184-75-8

Reaction Conditions

1.1 Reagents: Phosphorus pentoxide ,  Sodium bisulfate ;  3 h, rt

Reference

Mechanochemical sulfonation of aromatic compounds using NaHSO4·H2O/P2O5

Zuo, Lu-Lu; Qin, Shuai; Zhang, Pu ; Qin, Yu-Jun; Guo, Zhi-Xin, Journal of Chemical Research, 2021, 45(11-12), 942-949

2,4-Xylenesulfonic Acid Raw materials

• Benzenesulfonamide, 2,4-dimethyl-N-(2,3,4,5,6-pentafluorophenyl)-
• Benzenesulfonic acid, 2-amino-4,6-dimethyl-
• Benzenesulfonic acid, 2,4-dimethyl-, trimethylsilyl ester

2,4-Xylenesulfonic Acid Preparation Products

• Bismuthonium, triphenylsulfooxy-, inner salt (47318-40-1)
• 2,4-Xylenesulfonic Acid (88-61-9)
• Benzene,1,1'-sulfonylbis[2,4-dimethyl- (5184-75-8)

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• Solvents and Organic Chemicals Organic Compounds Acids/Esters
• Catalysts and Inorganic Chemicals Inorganic Compounds Salt

• 104-15-4(4-methylbenzene-1-sulfonic acid)
• 609-54-1(2,5-Dimethylbenzenesulfonic acid)
• 26447-10-9(Ammoniumxylenesulfonate -)
• 3453-83-6(2,4,6-Trimethylbenzenesulfonic acid)
• 66905-17-7(2,5-Dimethylbenzenesulfonic Acid Dihydrate)
• 25241-15-0(Benzenesulfonic acid,2,6-dimethyl-)
• 835617-36-2(Mesitylenesulfonic acid dihydrate)
• 25321-41-9(Dimethylbenzene Sulfonic Acid)
• 3453-84-7(2,4,5-Trimethylbenzenesulfonic acid)
• 6192-52-5(p-Toluenesulfonic acid monohydrate)