Production Method 1

373354-37-1

88-18-6

Reaction Conditions

1.1 Solvents: Chloroform

Reference

Photochemistry of 3-Substituted Bicyclo[3.1.0]hex-3-en-2-ones. Regioselective Synthesis of Ortho-Substituted Phenols by Pauson-Khand Reaction

Marchueta, Iolanda; et al, Organic Letters, 2001, 3(20), 3197-3200

Production Method 2

373354-37-1

88-18-6

Reaction Conditions

Reference

Product class: monohydric phenol, and corresponding phenolates - synthesis by rearrangement

Gonzalez-Bello, C.; et al, Science of Synthesis, 2007, 31, 319-330

Production Method 3

373354-37-1

88-18-6

Reaction Conditions

Reference

Product class 1: monohydric phenols and corresponding phenolates - synthesis from nonaromatic precursors

Thomas, A. W., Science of Synthesis, 2007, 31, 337-401

Production Method 4

2944-48-1

88-18-6

Reaction Conditions

1.1 Reagents: Diphenylphosphine ,  Potassium tert-butoxide Solvents: Dimethylformamide ;  10 min, rt
1.2 12 h, 80 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ;  pH 1 - 2

Reference

A mild and practical method for deprotection of aryl methyl/benzyl/allyl ethers with HPPh2 and tBuOK

Pan, Wenjing; et al, Organic & Biomolecular Chemistry, 2021, 19(35), 7633-7640

Production Method 5

676-58-4

346433-46-3

88-18-6

Reaction Conditions

1.1 Solvents: Diethyl ether
1.2 Reagents: Hydrochloric acid Solvents: Water

Reference

A Mild Anionic Method for Generating o-Quinone Methides: Facile Preparations of Ortho-Functionalized Phenols

Jones, Ryan M.; et al, Journal of Organic Chemistry, 2001, 66(10), 3435-3441

Production Method 6

88-18-6

Reaction Conditions

1.1 Solvents: Dimethyl sulfoxide

Reference

Dioxygen activation by an organometallic Pd(II) precursor: formation of a Pd(IV)-OH complex and its C-O bond formation reactivity

Qu, Fengrui; et al, Chemical Communications (Cambridge, 2014, 50(23), 3036-3039

Production Method 7

98-06-6

88-18-6

Reaction Conditions

Reference

Oxygen atoms by microwave discharge: reaction with arenes

Zadok, Elazar; et al, Angewandte Chemie, 1980, 92(12), 1037-8

Production Method 8

98-06-6

88-18-6

Reaction Conditions

1.1 Reagents: Boron trifluoride ,  Hydrofluoric acid ,  Hydrogen peroxide

Reference

Oxyfunctionalization of hydrocarbons. 11. Hydroxylation of benzene and alkylbenzenes with hydrogen peroxide in hydrogen fluoride/boron trifluoride

Olah, George A.; et al, Journal of Organic Chemistry, 1981, 46(21), 4305-6

Production Method 9

100-67-4

88-18-6

Reaction Conditions

1.1 Reagents: Phenol Solvents: Chloroform

Reference

Acidity effect in the regiochemical control of the alkylation of phenol with alkenes

Sartori, Giovanni; et al, Journal of the Chemical Society, 1997, (3), 257-260

Production Method 10

88-18-6

Reaction Conditions

Reference

Catalysis by 12-heteropolymolybdic acid. II. Friedel-Crafts-type reaction of aromatic compounds

Nomiya, Kenji; et al, Bulletin of the Chemical Society of Japan, 1980, 53(7), 2089-90

Production Method 11

88-18-6

Reaction Conditions

Reference

Alkylation of phenols by aluminum alkoxides

Iyer, Padmini; et al, Indian Journal of Chemistry, 1978, (4), 321-2

Production Method 12

88-18-6

Reaction Conditions

1.1 Catalysts: 1-Butyl-3-methylimidazolium tosylate ;  3 h, 80 °C

Reference

Application of ionic liquids as recyclable green catalysts for selective alkylation of phenol

Amirfirouzkouhi, Hamideh; et al, Separation and Purification Technology, 2018, 196, 132-139

Production Method 13

88-18-6

Reaction Conditions

Reference

Alkylation of phenol with α-methylstyrene, propylene, butenes, isoamylene, 1-octene, and diisobutylene: heterogeneous vs. homogeneous catalysts

Chaudhuri, Basab; et al, Industrial & Engineering Chemistry Research, 1991, 30(1), 227-31

Production Method 14

10323-39-4

88-18-6

Reaction Conditions

1.1 Solvents: Ethanol ,  Water

Reference

o-tert-Butylphenol

Hart, Harold, Journal of the American Chemical Society, 1949, 71, 1966-7

Production Method 15

88-18-6

Reaction Conditions

1.1 Reagents: Diphenylphosphine ,  Potassium tert-butoxide Solvents: Dimethylformamide ;  10 min, rt
1.2 12 h, 80 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ;  pH 1 - 2

Reference

A mild and practical method for deprotection of aryl methyl/benzyl/allyl ethers with HPPh2 and tBuOK

Pan, Wenjing; et al, Organic & Biomolecular Chemistry, 2021, 19(35), 7633-7640

Production Method 16

1634-04-4

88-18-6

Reaction Conditions

1.1 Catalysts: Phosphoric acid Solvents: Toluene ;  rt → 100 °C; 50 - 60 min, 95 - 100 °C; 100 °C → 125 °C; 3.5 h, 120 - 125 °C; 125 °C → 100 °C; 30 min, 100 °C

Reference

Improvement of synthesis process of TBHO

Xiong, De-qin; et al, Huaxue Yu Nianhe, 2007, 29(6), 442-444

Production Method 17

2089-03-4

88-18-6

Reaction Conditions

1.1 Reagents: Diphenylphosphine ,  Potassium tert-butoxide Solvents: Dimethylformamide ;  10 min, rt
1.2 12 h, 70 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ;  pH 1 - 2

Reference

A mild and practical method for deprotection of aryl methyl/benzyl/allyl ethers with HPPh2 and tBuOK

Pan, Wenjing; et al, Organic & Biomolecular Chemistry, 2021, 19(35), 7633-7640

Production Method 18

128-39-2

88-18-6

Reaction Conditions

Reference

Thermal de-tert-butylation of 2,6-di-tert-butylphenol and its derivatives

Kun, O. B.; et al, Zhurnal Organicheskoi Khimii, 1984, 20(12), 2608-11

Production Method 19

128-39-2

88-18-6

Reaction Conditions

Reference

Reaction of triphenylphosphine dibromide with o-tert-butylphenols

Lee, Donald G., Chemical Communications (London), 1968, (23), 1554-5

Production Method 20

88-18-6

Reaction Conditions

1.1 Reagents: Phenol, gallium salt (3:1)

Reference

Phenoxide compounds. III. tert-Butylation of phenols in the presence of phenoxides

Berny, Marie F., Bulletin de la Societe Chimique de France, 1969, (3), 973-6

Production Method 21

14874-70-5

594-19-4

88-18-6

Reaction Conditions

1.1 Solvents: Diethyl ether ,  Tetrahydrofuran
1.2 Reagents: Water
1.3 Reagents: Trimethylamine oxide Solvents: Acetonitrile
1.4 Reagents: Hydrochloric acid Solvents: Diethyl ether ,  Water

Reference

Studies on the Chemistry of Manganese Tricarbonyl Cations of Phenol and Cresols

Seo, Hwimin; et al, Organometallics, 2002, 21(16), 3417-3425

Production Method 22

15460-12-5

88-18-6

Reaction Conditions

Reference

Studies on selective preparation of aromatic compounds. XII. The selective reductive dehalogenation of some halophenols with zinc powder in basic and acidic media

Tashiro, Masashi; et al, Journal of Organic Chemistry, 1977, 42(5), 835-8

Production Method 23

88-18-6

Reaction Conditions

1.1 Reagents: Alumina ,  Silica Solvents: Dichloromethane

Reference

Silica gel as an effective catalyst for the alkylation of phenols and some heterocyclic aromatic compounds

Kamitori, Yasuhiro; et al, Journal of Organic Chemistry, 1984, 49(22), 4161-5

2-tert-Butylphenol Raw materials

• Borate(1-),tetrafluoro-
• BENZENE, 1-(1,1-DIMETHYLETHYL)-2-(2-PROPENYLOXY)-
• 2,4-dibromo-6-tert-butylphenol
• LITHIUM-2-METHYL-2-PROPANIDE
• Methylmagnesium Chloride (3M in THF)
• 2-(2-methoxyphenyl)propan-2-ol
• tert-Butylbenzene
• 4-Bromo-2-tert-butylphenol
• Bicyclo[3.1.0]hex-3-en-2-one, 3-(1,1-dimethylethyl)-
• Methyl 2-[[(1,1-dimethylethoxy)carbonyl]oxy]benzoate
• tert-Butyl methyl ether
• 2,6-Di-tert-butylphenol
• phenol;potassium salt

2-tert-Butylphenol Preparation Products

• 2-tert-Butylphenol (88-18-6)

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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylpropanes
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

• 57354-65-1(4-tert-Butyl-2,6-diisopropylphenol)
• 96-70-8(2-tert-butyl-4-ethylphenol)
• 96-76-4(2,4-Di-tert-butylphenol)
• 2525-39-5(Phenoxy, 2,4,6-tris(1,1-dimethylethyl)-)
• 25567-40-2(Phenol,(1,1-dimethylethyl)-4-methyl-)
• 22791-95-3(Phenol,2-(1,1-dimethylethyl)-6-(1-methylethyl)-)
• 5427-03-2(Phenol,2,6-bis(1,1-dimethylethyl)-4-(1-methylethyl)-)
• 19126-15-9(9H-Fluorene, 9-methoxy-)
• 6858-01-1(1,3-Ditert-butyl-2-lambda1-oxidanyl-5-methylbenzene)
• 15773-11-2(Phenoxy, 2,6-bis(1,1-dimethylethyl)-)