Production Method 1

56004-61-6

87976-26-9

Reaction Conditions

1.1 Reagents: Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Water ;  6 h, 100 °C; 100 °C → rt
1.2 Reagents: Potassium hydroxide ,  Sodium bisulfite Solvents: Water ;  pH 12, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ;  pH 2, rt

Reference

Synthesis and properties of stable isotope deuterium labeled D4-rhodamine B

Wang, Haoran; et al, Yingyong Huaxue, 2016, 33(8), 939-944

Production Method 2

88-99-3

87976-26-9

Reaction Conditions

1.1 Reagents: Hydrogen ,  Water-d2 Catalysts: Platinum ;  24 h, 180 °C

Reference

Aromatic ring favorable and efficient H-D exchange reaction catalyzed by Pt/C

Sajiki, Hironao; et al, Tetrahedron Letters, 2005, 46(41), 6995-6998

Production Method 3

56004-61-6

87976-26-9

Reaction Conditions

1.1 Reagents: Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Isobutanol ,  Water ;  2 h, reflux

Reference

An efficient and general method for the synthesis of stable isotope deuterium labeled phthalate esters

Xu, Zhongjie ; et al, Journal of Labelled Compounds and Radiopharmaceuticals, 2021, 64(10), 378-384

Production Method 4

56004-61-6

87976-26-9

Reaction Conditions

1.1 Reagents: Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Water ;  6 h, rt → reflux

Reference

Synthesis of the internal standard reagent diphenyl phthalate-D4 for plasticizer residue test

Xu, Zhong-jie; et al, Huaxue Shiji, 2019, 41(10), 1089-1092

Phthalic acid-d Raw materials

• o-Xylene-d10
• Phthalic acid

Phthalic acid-d Preparation Products

• Phthalic acid-d (87976-26-9)

• 1. Distinction of trans–cis photoisomers with comparable optical properties in multiple-state photochromic systems – examining a molecule with three azobenzenes via in situ irradiation NMR spectroscopy?
  Jonas Kind,Lukas Kaltschnee,Martin Leyendecker,Christina M. Thiele Chem. Commun., 2016,52, 12506-12509
• 2. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
• 3. Excitonic and vibrational coherence in artificial photosynthetic systems studied by negative-time ultrafast laser spectroscopy
  Dongjia Han,Bing Xue,Juan Du,Tomohiro Miyatake,Hitoshi Tamiaki,Xin Xing,Wei Yuan,Yanyan Li Phys. Chem. Chem. Phys., 2016,18, 24252-24260
• 4. Fe3O4/PEG-SO3H as a heterogeneous and magnetically-recyclable nanocatalyst for the oxidation of sulfides to sulfones or sulfoxides
  Saeideh Mirfakhraei,Malak Hekmati,Fereshteh Hosseini Eshbala,Hojat Veisi New J. Chem., 2018,42, 1757-1761
• 5. Excited-state proton-coupled electron transfer within ion pairs?
  Gerald J. Meyer,Leif Hammarstr?m Chem. Sci., 2020,11, 3460-3473

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acids

Phthalic acid-d: A Comprehensive Overview in Modern Chemical Research

Phthalic acid-d, with the CAS number 87976-26-9, is a significant compound in the field of chemical and pharmaceutical research. This derivative of phthalic acid has garnered considerable attention due to its unique structural properties and potential applications in various scientific domains. The inclusion of the deuterium isotope (D) in its molecular structure imparts distinct characteristics that make it a valuable tool for researchers exploring isotope labeling and molecular dynamics.

The chemical formula of Phthalic acid-d can be represented as C₈H₄D₂O_{4, reflecting its composition with deuterium atoms replacing hydrogen atoms. This modification enhances the compound's stability and isotopic purity, making it particularly useful in nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry studies. These analytical techniques are pivotal in elucidating the structural and dynamic properties of complex molecules, which are essential for drug discovery and development.}

In recent years, Phthalic acid-d has been extensively studied for its role in pharmaceutical synthesis. Its derivatives serve as key intermediates in the production of various therapeutic agents. For instance, researchers have explored its application in synthesizing nonsteroidal anti-inflammatory drugs (NSAIDs) and other bioactive molecules. The deuterium labeling technique allows for the precise tracking of metabolic pathways and drug interactions, providing invaluable insights into pharmacokinetics and pharmacodynamics.

The use of Phthalic acid-d in isotope labeling has also found relevance in environmental chemistry. Deuterated compounds are often employed to study environmental degradation processes and pollutant behavior. By incorporating deuterium atoms, scientists can monitor the fate of organic compounds in ecosystems more effectively. This approach is particularly useful in assessing the persistence and transformation of pollutants, aiding in the development of sustainable environmental management strategies.

Advancements in synthetic methodologies have further expanded the applications of Phthalic acid-d. Modern techniques such as catalytic hydrogenation and oxidation have enabled the efficient production of high-purity derivatives. These methods are crucial for ensuring that researchers obtain consistent and reliable results in their experiments. The compound's versatility makes it a preferred choice for both academic research and industrial applications.

The pharmaceutical industry has also embraced Phthalic acid-d for its potential in developing novel drug formulations. Its incorporation into drug molecules can enhance their bioavailability and therapeutic efficacy. Additionally, deuterium labeling can improve drug stability, extending shelf life and reducing degradation rates. These benefits are particularly significant in formulations intended for long-term use or challenging storage conditions.

In conclusion, Phthalic acid-d (CAS no: 87976-26-9) represents a fascinating compound with broad implications across multiple scientific disciplines. Its unique isotopic composition and structural properties make it an indispensable tool for researchers engaged in pharmaceutical synthesis, environmental studies, and material science. As scientific understanding continues to evolve, the applications of Phthalic acid-d are expected to expand, further solidifying its role as a cornerstone in modern chemical research.

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