Cas no 87913-26-6 (Bromantane)

Bromantane (C16H20BrNO2) is a synthetic adamantane derivative with psychostimulant and anxiolytic properties. Its mechanism of action involves modulating dopaminergic and serotonergic neurotransmission while enhancing stress resistance through indirect effects on the gamma-aminobutyric acid (GABA) system. Bromantane exhibits a favorable pharmacokinetic profile, including good oral bioavailability and prolonged duration of action. Unlike classical stimulants, it demonstrates minimal peripheral side effects and low abuse potential. The compound has shown potential in improving cognitive performance under fatigue conditions and enhancing physical endurance. Its unique dual-action profile makes it a subject of interest for research in neuropharmacology and stress-related disorders.
Bromantane structure
Bromantane structure
Product Name:Bromantane
CAS No:87913-26-6
MF:C16H20BrN
MW:306.240703582764
CID:726407
PubChem ID:4660557
Update Time:2025-06-07

Bromantane Chemical and Physical Properties

Names and Identifiers

    • Tricyclo[3.3.1.13,7]decan-2-amine,N-(4-bromophenyl)-
    • Bromantane
    • N-(2-ADAMANTYL)-N-(4-BROMOPHENYL)AMINE
    • N-(4-bromophenyl)adamantan-2-amine
    • 2-(4-Bromophenyl)aminoadamantane
    • Bromantan
    • N-(4-Bromophenyl)-tricyclo[3.3.1.1(3,7)]decan-2-amine
    • N-(4-Bromophenyl)tricyclo[3.3.1.13,7]decan-2-amine (ACI)
    • DB-082762
    • 87913-26-6
    • AKOS037644786
    • Tricyclo[3.3.1.13,7]decan-2-amine, N-(4-bromophenyl)-
    • 2-bromophenyl-1-amino adamantane
    • Z440843598
    • DTXSID40405333
    • EN300-154642
    • Ladasten
    • AS-54469
    • A842407
    • N-(4-bromophenyl)-2-adamantanamine
    • Tricyclo(3.3.1.13,7)decan-2-amine, N-(4-bromophenyl)-
    • BRD-K86358349-001-02-0
    • UNII-N1ILS53XWK
    • ALBB-035069
    • BROMANTANE [WHO-DD]
    • AKOS004120981
    • N-(2-adamantyl)-N-(p-bromophenyl)-amine
    • NS00093636
    • DTXCID10356186
    • Tricyclo[3.3.1.13,7]decan-2-amine, N-(4-bromophenyl)-; N-(4-Bromophenyl)tricyclo[3.3.1.13,7]decan-2-amine; Bromantan; Bromantane
    • GLXC-02985
    • bromontan
    • Q385533
    • N-(4-Bromophenyl)tricyclo(3.3.1.13,7)decan-2-amine
    • N-(2-Adamantyl)-N-(4-bromophenyl)-amine
    • S10385
    • BRD-K86358349-001-01-2
    • CHEMBL4303520
    • SCHEMBL737152
    • N1ILS53XWK
    • Inchi： 1S/C16H20BrN/c17-14-1-3-15(4-2-14)18-16-12-6-10-5-11(8-12)9-13(16)7-10/h1-4,10-13,16,18H,5-9H2
    • InChI Key： LWJALJDRFBXHKX-UHFFFAOYSA-N
    • SMILES： BrC1C=CC(NC2C3CC4CC(C3)CC2C4)=CC=1

Computed Properties

  • Exact Mass: 305.07800
  • Monoisotopic Mass: 305.078
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 18
  • Rotatable Bond Count: 2
  • Complexity: 280
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: 5
  • Topological Polar Surface Area: 12A^2

Experimental Properties

  • Density: 1.388±0.06 g/cm3 (20 oC 760 Torr),
  • Boiling Point: 404.8 °C at 760 mmHg
  • Flash Point: 198.6 °C
  • Solubility: Insuluble (8.3E-4 g/L) (25 oC),
  • PSA: 12.03000
  • LogP: 4.75870

Bromantane Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
TRC
B678450-500mg
Bromantane
 87913-26-6
500mg
 $ 227.00 2023-09-08
TRC
B678450-5g
Bromantane
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 $ 1777.00 2023-09-08
SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd.
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 87913-26-6 98%
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Enamine
EN300-154642-50mg
N-(4-bromophenyl)adamantan-2-amine
 87913-26-6 95.0%
50mg
 $151.0 2023-09-25
Enamine
EN300-154642-100mg
N-(4-bromophenyl)adamantan-2-amine
 87913-26-6 95.0%
100mg
 $225.0 2023-09-25
Enamine
EN300-154642-250mg
N-(4-bromophenyl)adamantan-2-amine
 87913-26-6 95.0%
250mg
 $321.0 2023-09-25
Enamine
EN300-154642-500mg
N-(4-bromophenyl)adamantan-2-amine
 87913-26-6 95.0%
500mg
 $506.0 2023-09-25
Enamine
EN300-154642-1000mg
N-(4-bromophenyl)adamantan-2-amine
 87913-26-6 95.0%
1000mg
 $649.0 2023-09-25
Enamine
EN300-154642-2500mg
N-(4-bromophenyl)adamantan-2-amine
 87913-26-6 95.0%
2500mg
 $1270.0 2023-09-25
Enamine
EN300-154642-5000mg
N-(4-bromophenyl)adamantan-2-amine
 87913-26-6 95.0%
5000mg
 $1879.0 2023-09-25

Bromantane Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Sodium tert-butoxide Catalysts: Bis(dibenzylideneacetone)palladium ,  BINAP Solvents: 1,4-Dioxane ;  7 h, reflux
Reference
Palladium-catalyzed amination of isomeric dihalobenzenes with 1- and 2-aminoadamantanes
Averin, A. D.; et al, Russian Journal of Organic Chemistry, 2010, 46(1), 64-72

Production Method 2

Reaction Conditions
1.1 Reagents: 1,3,5-Trioxane ,  Hydrochloric acid
Reference
N-Adamantyl derivatives of aromatic amines. I. Synthesis and neurotropic activity of N-(adamant-2-yl)anilines
Morozov, I. S.; et al, Khimiko-Farmatsevticheskii Zhurnal, 1998, 32(1), 3-6

Production Method 3

Reaction Conditions
1.1 Reagents: Carbon monoxide Catalysts: Ruthenium trichloride Solvents: Acetonitrile ;  11 h, 30 atm, 140 °C
Reference
Ruthenium-Catalyzed Reductive Amination without an External Hydrogen Source
Kolesnikov, Pavel N.; et al, Organic Letters, 2015, 17(2), 173-175

Production Method 4

Reaction Conditions
1.1 Reagents: Sodium tert-butoxide Catalysts: Bis(dibenzylideneacetone)palladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: 1,4-Dioxane ;  7 h, reflux
Reference
Palladium-catalyzed amination of isomeric dihalobenzenes with 1- and 2-aminoadamantanes
Averin, A. D.; et al, Russian Journal of Organic Chemistry, 2010, 46(1), 64-72

Production Method 5

Reaction Conditions
1.1 Reagents: Sodium tert-butoxide Catalysts: Bis(dibenzylideneacetone)palladium ,  2′-(Dicyclohexylphosphino)-N,N-dimethyl[1,1′-biphenyl]-2-amine Solvents: 1,4-Dioxane ;  7 h, reflux
Reference
Palladium-catalyzed amination of isomeric dihalobenzenes with 1- and 2-aminoadamantanes
Averin, A. D.; et al, Russian Journal of Organic Chemistry, 2010, 46(1), 64-72

Bromantane Raw materials

Bromantane Preparation Products

Bromantane Related Literature

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