Cas no 879-18-5 (1-Naphthoyl chloride)

1-Naphthoyl chloride (C??H?ClO) is a versatile organic compound primarily used as an acylating agent in synthetic chemistry. Its naphthalene backbone and reactive acyl chloride group make it valuable for introducing the 1-naphthoyl moiety into target molecules, facilitating the synthesis of dyes, pharmaceuticals, and specialty chemicals. The compound exhibits high reactivity with nucleophiles, enabling efficient amidation and esterification reactions. It is typically handled under anhydrous conditions due to moisture sensitivity. Key advantages include its role in producing intermediates with enhanced aromatic properties and its utility in constructing complex molecular architectures. Proper storage and handling are essential to maintain stability and prevent hydrolysis.
1-Naphthoyl chloride structure
1-Naphthoyl chloride structure
Product Name:1-Naphthoyl chloride
CAS No:879-18-5
MF:C11H7ClO
MW:190.625682115555
MDL:MFCD00004002
CID:40177
PubChem ID:70146
Update Time:2025-05-23

1-Naphthoyl chloride Chemical and Physical Properties

Names and Identifiers

    • 1-Naphthoyl chloride
    • 1-NAPHTHALENECARBONYL CHLORIDE
    • naphthalene-1-carbonyl chloride
    • 1-Naphthoylchloride
    • 1-Naphthoic acid chloride
    • 1-(Chlorocarbonyl)naphthalene
    • alpha-Naphthoyl chloride
    • .alpha.-Naphthoyl chloride
    • naphthalenecarbonyl chloride
    • NSNPSJGHTQIXDO-UHFFFAOYSA-N
    • naphthoylchloride
    • naphthoyl chloride
    • l-naphthoylchloride
    • 1-Napthoylchloride
    • 1-napthoyl chloride
    • 1-naphtoyl chloride
    • l-naphthoyl chloride
    • 1-naphthaloylchlorid
    • 1-Naphthoyl chloride (6CI, 7CI, 8CI)
    • 1-Naphthalenecarboxylic acid chloride
    • 1-Naphthaloyl chloride
    • 1-Naphthylcarbonyl chloride
    • NSC 9841
    • α-Naphthoyl chloride
    • EN300-33504
    • F2190-0085
    • 1-Naphthylcarbonyl Chloride; NSC 9841; a-Naphthoyl Chloride;
    • AKOS005259079
    • InChI=1/C11H7ClO/c12-11(13)10-7-3-5-8-4-1-2-6-9(8)10/h1-7H
    • 1-Naphthoyl Chloride; 1-(Chlorocarbonyl)naphthalene;
    • NSC-9841
    • NS00043157
    • SCHEMBL123694
    • W-104001
    • NSC9841
    • F11279
    • naphthalene-1-carboxylic acid chloride
    • DTXSID4061252
    • N0047
    • DB-000119
    • napthalene-1-carbonyl chloride
    • NSNPSJGHTQIXDO-UHFFFAOYSA-
    • MFCD00004002
    • 879-18-5
    • 1-naphthaloylchloride
    • 1-Naphthoyl chloride, 97%
    • 1-Naphthalenecarbonylchloride1-Naphthoylchloride
    • 1-Naphthalenecarboxylic Acid Chloride; 1-Naphthoic Acid Chloride;
    • QEJ8QRD2LC
    • AS-14388
    • EINECS 212-903-9
    • BP-10738
    • MDL： MFCD00004002
    • Inchi： 1S/C11H7ClO/c12-11(13)10-7-3-5-8-4-1-2-6-9(8)10/h1-7H
    • InChI Key： NSNPSJGHTQIXDO-UHFFFAOYSA-N
    • SMILES： O=C(C1C2C(=CC=CC=2)C=CC=1)Cl
    • BRN： 775785

Computed Properties

  • Exact Mass: 190.01900
  • Monoisotopic Mass: 190.019
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 13
  • Rotatable Bond Count: 1
  • Complexity: 202
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 4.1
  • Topological Polar Surface Area: 17.1
  • Surface Charge: 0
  • Tautomer Count: nothing

Experimental Properties

  • Color/Form: Colorless Transparent Liquid
  • Density: 1.265?g/mL?at 25?°C(lit.)
  • Melting Point: 16-19?°C (lit.)
  • Boiling Point: 190?°C/35?mmHg(lit.)
  • Flash Point: Degrees Fahrenheit:>230°F
    Degrees Celsius:>110°C
  • Refractive Index: n20/D 1.652(lit.)
  • Water Partition Coefficient: Reacts with water.
  • Stability/Shelf Life: Stable. Incompatible with water, moisture, strong oxidizing agents, bases.
  • PSA: 17.07000
  • LogP: 3.21880
  • Solubility: Not determined
  • Sensitiveness: Moisture Sensitive

1-Naphthoyl chloride Security Information

  • Symbol: GHS05
  • Prompt：dangerous
  • Signal Word：Danger
  • Hazard Statement： H314
  • Warning Statement： P280,P305+P351+P338,P310
  • Hazardous Material transportation number：UN 3261 8/PG 2
  • WGK Germany：3
  • Hazard Category Code： 34-37
  • Safety Instruction： S26-S36/37/39-S45-S28A-S60-S30-S20-S8
  • FLUKA BRAND F CODES：21
  • Hazardous Material Identification： C
  • Safety Term：8
  • Packing Group：II
  • Risk Phrases：R34
  • HazardClass：8
  • PackingGroup：III
  • TSCA：Yes
  • Storage Condition：Store at room temperature

1-Naphthoyl chloride Customs Data

  • HS CODE：2916399090
  • Customs Data：

    China Customs Code:

    2916399090

    Overview:

    2916399090 Other aromatic monocarboxylic acids. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:6.5% general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to, Acrylic acid\Acrylates or esters shall be packaged clearly

    Summary:

    2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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1-Naphthoyl chloride Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Oxalyl chloride Catalysts: Dimethylformamide Solvents: Dichloromethane ;  rt → 0 °C; 0 °C; 5 h, rt
Reference
Direct Construction of Fused/Bridged 3D Rings via Visible-Light Induced Dearomative Cycloaddition of Arenes
Zhen, Guangjin; et al, Advanced Synthesis & Catalysis, 2023, 365(1), 43-52

Production Method 2

Reaction Conditions
1.1 Catalysts: Dimethylformamide Solvents: Dichloromethane ;  5 min, 0 °C
1.2 Reagents: Oxalyl chloride ;  0 °C; 12 h, rt
Reference
Chiral Bronsted acid-catalyzed dynamic kinetic resolution of atropisomeric ortho-formyl naphthamides
Gao, Zeng; et al, Chemical Communications (Cambridge, 2020, 56(53), 7265-7268

Production Method 3

Reaction Conditions
1.1 Catalysts: Tris(dibenzylideneacetone)dipalladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Toluene ;  12 h, 125 °C
Reference
Metathesis-active ligands enable a catalytic functional group metathesis between aroyl chlorides and aryl iodides
Lee, Yong Ho ; et al, Nature Chemistry, 2018, 10(10), 1016-1022

Production Method 4

Reaction Conditions
1.1 Catalysts: Tris(dibenzylideneacetone)dipalladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Toluene ;  12 h, 100 °C
Reference
Metathesis-active ligands enable a catalytic functional group metathesis between aroyl chlorides and aryl iodides
Lee, Yong Ho ; et al, Nature Chemistry, 2018, 10(10), 1016-1022

Production Method 5

Reaction Conditions
1.1 Catalysts: Tris(dibenzylideneacetone)dipalladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Toluene ;  12 h, 100 °C
2.1 Catalysts: Tris(dibenzylideneacetone)dipalladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Toluene ;  12 h, 100 °C
Reference
Metathesis-active ligands enable a catalytic functional group metathesis between aroyl chlorides and aryl iodides
Lee, Yong Ho ; et al, Nature Chemistry, 2018, 10(10), 1016-1022

Production Method 6

Reaction Conditions
1.1 Catalysts: Tris(dibenzylideneacetone)dipalladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Toluene ;  12 h, 125 °C
2.1 Catalysts: Tris(dibenzylideneacetone)dipalladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Toluene ;  12 h, 100 °C
Reference
Metathesis-active ligands enable a catalytic functional group metathesis between aroyl chlorides and aryl iodides
Lee, Yong Ho ; et al, Nature Chemistry, 2018, 10(10), 1016-1022

Production Method 7

Reaction Conditions
1.1 Catalysts: Tris(dibenzylideneacetone)dipalladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Toluene ;  12 h, 100 °C
2.1 Catalysts: Tris(dibenzylideneacetone)dipalladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Toluene ;  12 h, 100 °C
Reference
Metathesis-active ligands enable a catalytic functional group metathesis between aroyl chlorides and aryl iodides
Lee, Yong Ho ; et al, Nature Chemistry, 2018, 10(10), 1016-1022

Production Method 8

Reaction Conditions
1.1 Catalysts: Tris(dibenzylideneacetone)dipalladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Toluene ;  12 h, 100 °C
2.1 Catalysts: Tris(dibenzylideneacetone)dipalladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Toluene ;  12 h, 100 °C
Reference
Metathesis-active ligands enable a catalytic functional group metathesis between aroyl chlorides and aryl iodides
Lee, Yong Ho ; et al, Nature Chemistry, 2018, 10(10), 1016-1022

Production Method 9

Reaction Conditions
1.1 Catalysts: Tris(dibenzylideneacetone)dipalladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Toluene ;  12 h, 100 °C
2.1 Catalysts: Tris(dibenzylideneacetone)dipalladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Toluene ;  12 h, 100 °C
Reference
Metathesis-active ligands enable a catalytic functional group metathesis between aroyl chlorides and aryl iodides
Lee, Yong Ho ; et al, Nature Chemistry, 2018, 10(10), 1016-1022

Production Method 10

Reaction Conditions
1.1 Catalysts: Tris(dibenzylideneacetone)dipalladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Toluene ;  12 h, 100 °C
2.1 Catalysts: Tris(dibenzylideneacetone)dipalladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Toluene ;  12 h, 100 °C
Reference
Metathesis-active ligands enable a catalytic functional group metathesis between aroyl chlorides and aryl iodides
Lee, Yong Ho ; et al, Nature Chemistry, 2018, 10(10), 1016-1022

Production Method 11

Reaction Conditions
1.1 Catalysts: Dimethylformamide Solvents: Dichloromethane ;  5 min, 0 °C
1.2 Reagents: Oxalyl chloride ;  0 °C; 4 h, 25 °C
Reference
Simple and Practical Conversion of Benzoic Acids to Phenols at Room Temperature
Xiong, Wenzhang; et al, Journal of the American Chemical Society, 2022, 144(34), 15894-15902

Production Method 12

Reaction Conditions
1.1 Reagents: Benzyltriphenylphosphonium chloride Catalysts: Bis(tri-tert-butylphosphine)palladium Solvents: Toluene ;  24 h, 22 °C → 110 °C
Reference
A Palladium-Catalyzed Carbonylation Approach to Acid Chloride Synthesis
Quesnel, Jeffrey S.; et al, Journal of the American Chemical Society, 2013, 135(45), 16841-16844

Production Method 13

Reaction Conditions
1.1 Reagents: Benzyltriphenylphosphonium chloride Catalysts: Bis(tri-tert-butylphosphine)palladium Solvents: Toluene ;  24 h, 20 atm, rt → 110 °C
Reference
Acid chloride synthesis by the palladium-catalyzed chlorocarbonylation of aryl bromides
Quesnel, Jeffrey S.; et al, Chemistry - A European Journal, 2015, 21(26), 9550-9555

Production Method 14

Reaction Conditions
1.1 Catalysts: 2241736-67-2 Solvents: Benzene-d6 ;  20 h, 110 °C
Reference
Functional Group Transposition: A Palladium-Catalyzed Metathesis of Ar-X σ-Bonds and Acid Chloride Synthesis
De La Higuera Macias, Maximiliano; et al, Journal of the American Chemical Society, 2018, 140(32), 10140-10144

Production Method 15

Reaction Conditions
1.1 Catalysts: 2241736-67-2 Solvents: Benzene ;  20 h, 90 °C
Reference
Functional Group Transposition: A Palladium-Catalyzed Metathesis of Ar-X σ-Bonds and Acid Chloride Synthesis
De La Higuera Macias, Maximiliano; et al, Journal of the American Chemical Society, 2018, 140(32), 10140-10144

Production Method 16

Reaction Conditions
1.1 Catalysts: Tris(dibenzylideneacetone)dipalladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Toluene ;  12 h, 100 °C
2.1 Catalysts: Tris(dibenzylideneacetone)dipalladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Toluene ;  12 h, 100 °C
Reference
Metathesis-active ligands enable a catalytic functional group metathesis between aroyl chlorides and aryl iodides
Lee, Yong Ho ; et al, Nature Chemistry, 2018, 10(10), 1016-1022

Production Method 17

Reaction Conditions
1.1 Catalysts: Tris(dibenzylideneacetone)dipalladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Toluene ;  12 h, 100 °C
2.1 Catalysts: Tris(dibenzylideneacetone)dipalladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Toluene ;  12 h, 100 °C
Reference
Metathesis-active ligands enable a catalytic functional group metathesis between aroyl chlorides and aryl iodides
Lee, Yong Ho ; et al, Nature Chemistry, 2018, 10(10), 1016-1022

Production Method 18

Reaction Conditions
1.1 Catalysts: Tris(dibenzylideneacetone)dipalladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Toluene ;  12 h, 100 °C
2.1 Catalysts: Tris(dibenzylideneacetone)dipalladium ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Toluene ;  12 h, 100 °C
Reference
Metathesis-active ligands enable a catalytic functional group metathesis between aroyl chlorides and aryl iodides
Lee, Yong Ho ; et al, Nature Chemistry, 2018, 10(10), 1016-1022

1-Naphthoyl chloride Raw materials

1-Naphthoyl chloride Preparation Products

1-Naphthoyl chloride Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd
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(CAS:879-18-5)1-Naphthoyl Chloride
Order Number:LE1459;LE1755198
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 11:40
Price ($):discuss personally

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Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:879-18-5)1-Naphthoyl Chloride
LE1459;LE1755198
Purity:99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry
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