Production Method 1

878285-14-4

452-77-7

452-80-2

878285-13-3

Reaction Conditions

1.1 Reagents: Trifluoromethanesulfonic acid ,  Fluorine ;  rt
1.2 Reagents: Sodium hydroxide Solvents: Water ;  neutralized, rt

Reference

Electrophilic aromatic fluorination with fluorine: meta-Directed fluorination of anilines

Alric, J. P.; Marquet, B.; Billard, T.; Langlois, B. R., Journal of Fluorine Chemistry, 2005, 126(4), 661-667

2,5-Difluoro-4-methylaniline Preparation Products

• 3-Fluoro-4-methylaniline (452-77-7)
• 2-Fluoro-4-methylaniline (452-80-2)
• 3,5-Difluoro-4-methylaniline (878285-13-3)
• 2,5-Difluoro-4-methylaniline (878285-14-4)

• 1. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 2. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 3. Emerging investigators
  Polym. Chem., 2015,6, 5501-5502
• 4. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
  Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696
• 5. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Aminotoluenes
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Toluenes Aminotoluenes
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

• 119915-59-2(Benzenamine,2,3,5-trifluoro-4-methyl-)
• 119916-26-6(Benzenamine,2,4,5-trifluoro-3-methyl-)
• 76350-70-4(2,4-Difluoro-3-methylaniline)
• 144851-63-8(2,6-Difluoro-3-methylaniline)
• 4127-63-3(2,3,5,6-tetrafluoro-4-methylaniline)
• 401909-15-7(Benzenemethanamine, 4-amino-2,5-difluoro- (9CI))
• 1978-33-2(2-Fluoro-3-methylaniline)
• 452-77-7(3-Fluoro-4-methylaniline)
• 452-80-2(2-Fluoro-4-methylaniline)
• 886503-79-3(2,3-Difluoro-4-methylaniline)