Production Method 1

214360-73-3

1189-71-5

877134-77-5

Reaction Conditions

1.1 Solvents: Dichloromethane ;  2 h, rt

Reference

ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism

Luo, Lusong; et al, Nature Chemical Biology, 2007, 3(11), 722-726

Production Method 2

214360-73-3

1189-71-5

877134-77-5

Reaction Conditions

1.1 Solvents: Dichloromethane ;  1 h, 0 °C
1.2 Reagents: Water ;  2 h, 0 °C

Reference

Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa

Kitamura, Seiya; et al, Journal of Medicinal Chemistry, 2016, 59(10), 4790-4799

4-(Carbamoylamino)benzeneboronic Acid Pinacol Ester Raw materials

• 4-Aminophenylboronic acid pinacol ester
• Chlorosulfonyl isocyanate

4-(Carbamoylamino)benzeneboronic Acid Pinacol Ester Preparation Products

• 4-(Carbamoylamino)benzeneboronic Acid Pinacol Ester (877134-77-5)

• 1. Emerging investigator series: first-principles and thermodynamics comparison of compositionally-tuned delafossites: cation release from the (001) surface of complex metal oxides?
  Joseph W. Bennett,Diamond T. Jones,Blake G. Hudson,Joshua Melendez-Rivera,Robert J. Hamers,Sara E. Mason Environ. Sci.: Nano, 2020,7, 1642-1651
• 2. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 3. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847
• 4. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
• 5. Evolution of shape, size, and areal density of a single plane of Si nanocrystals embedded in SiO2 matrix studied by atom probe tomography
  Bin Han,Yasuo Shimizu,Gabriele Seguini,Celia Castro,Gérard Ben Assayag,Koji Inoue,Yasuyoshi Nagai,Sylvie Schamm-Chardon,Michele Perego RSC Adv., 2016,6, 3617-3622

Comprehensive Overview of 4-(Carbamoylamino)benzeneboronic Acid Pinacol Ester (CAS No. 877134-77-5)

4-(Carbamoylamino)benzeneboronic Acid Pinacol Ester (CAS No. 877134-77-5) is a highly specialized boronic acid derivative widely utilized in organic synthesis, pharmaceutical research, and material science. This compound belongs to the class of arylboronic esters, which are pivotal intermediates in Suzuki-Miyaura cross-coupling reactions—a cornerstone of modern drug discovery and agrochemical development. Its unique structure, featuring a carbamoylamino group and a pinacol-protected boronic ester, enhances stability and reactivity, making it indispensable for targeted molecular design.

The growing demand for 4-(Carbamoylamino)benzeneboronic Acid Pinacol Ester is driven by its applications in precision medicine and bioconjugation. Researchers frequently search for "boronic ester solubility," "Suzuki coupling optimization," and "arylboronate stability," reflecting its relevance in high-throughput screening and catalyst-free reactions. Recent advancements in cancer therapeutics have also spotlighted this compound due to its role in synthesizing kinase inhibitors and proteolysis-targeting chimeras (PROTACs).

From a synthetic chemistry perspective, the pinacol ester moiety in CAS No. 877134-77-5 offers superior handling advantages, mitigating the hygroscopic nature of free boronic acids. This property aligns with industry trends toward air-stable reagents, a topic frequently queried in AI-driven literature searches. Additionally, its compatibility with green chemistry protocols—such as aqueous-phase reactions—addresses environmental concerns, a hotspot in sustainable pharmaceutical manufacturing.

Analytical characterization of 4-(Carbamoylamino)benzeneboronic Acid Pinacol Ester typically involves NMR spectroscopy, HPLC purity testing, and mass spectrometry. These techniques ensure compliance with Good Manufacturing Practice (GMP) standards, a critical consideration for contract research organizations (CROs). The compound’s structure-activity relationship (SAR) data is also curated in cheminformatics databases, supporting AI-assisted drug design initiatives.

In summary, CAS No. 877134-77-5 exemplifies the intersection of innovation and practical utility in organoboron chemistry. Its adaptability to automated synthesis platforms and bioorthogonal labeling techniques positions it as a key player in next-generation therapeutic development. For researchers exploring "boronic acid derivatives in drug delivery" or "pinacol ester hydrolysis kinetics," this compound offers a robust scaffold for cutting-edge applications.

• 480424-94-0(4-Formamidophenylboronic acid, pinacol ester)
• 874291-03-9(4-(3-Isobutylureido)phenylboronic acid, pinacol ester)
• 874291-00-6(4-(3-Ethylureido)phenylboronic acid, pinacol ester)
• 874297-78-6(4-(3-t-Butyllureido)phenylboronic acid, pinacol ester)
• 874291-01-7(1-Propyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea)
• 874291-02-8(4-(3-Isopropylureido)phenylboronic acid, pinacol ester)
• 480425-37-4(3-Formamidophenylboronic Acid Pinacol Ester)
• 710348-69-9(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazol-2(3H)-one)
• 874290-99-0(1-Methyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea)
• 874290-93-4(4-(3-Dimethylureido)phenylboronic acid, pinacol ester)