Production Method 1

705-76-0

877-88-3

Reaction Conditions

1.1 Reagents: Phosphorus tribromide Solvents: 1,4-Dioxane ;  1 h, 40 °C; 40 °C → rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  rt

Reference

Studies toward the synthesis of caramboxin analogues

Filho, Ronaldo E. Oliveira; Higa, Vanessa M. ; Omori, Alvaro T., Journal of the Brazilian Chemical Society, 2019, 30(3), 528-540

Production Method 2

705-76-0

877-88-3

Reaction Conditions

1.1 Reagents: Triphenylphosphine Solvents: Dichloromethane ;  10 min, rt
1.2 Reagents: Carbon tetrabromide ;  -78 °C; 80 min, -50 °C

Reference

Synthesis and biological evaluation of bilobol and adipostatin A

Tanaka, Ayano; Arai, Yasuhiro; Kim, Su-Nam; Ham, Jungyeob; Usuki, Toyonobu, Journal of Asian Natural Products Research, 2011, 13(4), 290-296

Production Method 3

705-76-0

877-88-3

Reaction Conditions

1.1 Reagents: Pyridine ,  Phosphorus tribromide Solvents: Dichloromethane ;  0 °C; 4 h, 0 °C → rt
1.2 Solvents: Water ;  cooled

Reference

Design, synthesis, and evaluation of resveratrol derivatives as Ass1-42 aggregation inhibitors, antioxidants, and neuroprotective agents

Lu, Chuanjun; Guo, Yueyan; Li, Jianheng; Yao, Meicun; Liao, Qiongfeng; et al, Bioorganic & Medicinal Chemistry Letters, 2012, 22(24), 7683-7687

Production Method 4

705-76-0

2857-97-8

877-88-3

Reaction Conditions

Reference

Synthesis of nonadeutero olivetol and nonadeutero cannabinoids

Seltzman, Herbert H.; Begum, Mosammat K.; Wyrick, Christopher D., Journal of Labelled Compounds and Radiopharmaceuticals, 1991, 29(9), 1009-18

Production Method 5

705-76-0

877-88-3

Reaction Conditions

1.1 Reagents: Phosphorus tribromide Solvents: Dichloromethane ;  0 °C; 2 h, 0 °C; 0 °C → rt; 1 h, rt
1.2 Solvents: Water ;  0 °C; 0 °C → rt

Reference

Simple and high-efficiency method for synthesis of trans-resveratrol

, China, , ,

Production Method 6

705-76-0

877-88-3

Reaction Conditions

1.1 Reagents: Phosphorus tribromide Solvents: Dichloromethane ;  2 h, rt

Reference

Synthesis of cannabinol by a modified Ullmann-Ziegler cross-coupling

Nuellen, Max P.; Goettlich, Richard, Synlett, 2013, 24(9), 1109-1112

Production Method 7

705-76-0

877-88-3

Reaction Conditions

1.1 Reagents: Pyridine ,  Phosphorus tribromide Solvents: Diethyl ether ;  25 °C; 3 h, 40 °C

Reference

Total synthesis of resveratrol-based natural products: a chemoselective solution

Snyder, Scott A.; Zografos, Alexandros L.; Lin, Yunqing, Angewandte Chemie, 2007, 46(43), 8186-8191

Production Method 8

705-76-0

877-88-3

Reaction Conditions

1.1 Reagents: Phosphorus tribromide Solvents: Dichloromethane ;  cooled; 4.5 h, rt
1.2 Reagents: Water ;  cooled

Reference

Synthesis and HIV-1 inhibitory activity of natural products isolated from Gnetum parvifolium and their analogues

Piao, Zhisong; Feng, Yabing; Wang, Lin; Zhang, Xingquan; Lin, Mao, Yaoxue Xuebao, 2010, 45(12), 1509-1515

Production Method 9

705-76-0

877-88-3

Reaction Conditions

1.1 Reagents: Phosphorus tribromide Solvents: Diethyl ether ;  0 °C; 30 min, 0 °C
1.2 Reagents: Potassium bromide Solvents: Water ;  0 °C

Reference

Synthesis and biological evaluation of novel resveratrol-oxadiazole hybrid heterocycles as potential antiproliferative agents

Murty, M. S. R.; Penthala, Raju; Polepalli, Sowjanya; Jain, N., Medicinal Chemistry Research, 2016, 25(4), 627-643

Production Method 10

705-76-0

877-88-3

Reaction Conditions

1.1 Reagents: Pyridine ,  Phosphorus tribromide Solvents: Dichloromethane ;  0 °C; 0 °C → rt; 4 h, rt
1.2 Reagents: Water ;  cooled

Reference

Multitarget-directed resveratrol derivatives: anti-cholinesterases, anti-β-amyloid aggregation and monoamine oxidase inhibition properties against Alzheimer's disease

Pan, Long-Fei; Wang, Xiao-Bing; Xie, Sai-Sai; Li, Su-Yi; Kong, Ling-Yi, MedChemComm, 2014, 5(5), 609-616

Production Method 11

705-76-0

877-88-3

Reaction Conditions

1.1 Reagents: Phosphorus tribromide Solvents: Dichloromethane ;  0 °C; 4 h, rt

Reference

Design, synthesis and antiproliferative activity of the new conjugates of E7010 and resveratrol as tubulin polymerization inhibitors

Kamal, Ahmed; Ashraf, Md.; Basha, Shaik Thokhir; Ali Hussaini, S. M.; Singh, Shamshair; et al, Organic & Biomolecular Chemistry, 2016, 14(4), 1382-1394

Production Method 12

705-76-0

877-88-3

Reaction Conditions

1.1 Reagents: Pyridine ,  Phosphorus tribromide Solvents: Diethyl ether ;  25 °C; 3 h, 40 °C
1.2 Reagents: Water ;  cooled

Reference

Total Synthesis of Diverse Carbogenic Complexity within the Resveratrol Class from a Common Building Block

Snyder, Scott A.; Breazzano, Steven P.; Ross, Audrey G.; Lin, Yunqing; Zografos, Alexandros L., Journal of the American Chemical Society, 2009, 131(5), 1753-1765

Production Method 13

705-76-0

877-88-3

Reaction Conditions

1.1 Reagents: Phosphorus tribromide Solvents: Dichloromethane

Reference

A convenient synthesis of 14C-labeled resveratrol

Zeng, Dongli; Mi, Qixi; Sun, Hongfang; Wang, Haifang, Journal of Labelled Compounds & Radiopharmaceuticals, 2004, 47(3), 167-174

Production Method 14

7311-34-4

877-88-3

Reaction Conditions

1.1 Reagents: Sodium borohydride Solvents: Ethanol ;  1 - 3 h, 0 °C
1.2 Reagents: Sulfuric acid Solvents: Water ;  acidified
1.3 Reagents: Phosphorus tribromide Solvents: Diethyl ether ;  3 - 12 h, 0 °C
1.4 Reagents: Water

Reference

New potential mammalian lignan metabolites of environmental phytoestrogens

Raffaelli, Barbara; Leppala, Eija; Chappuis, Clement; Wahala, Kristiina, Environmental Chemistry Letters, 2006, 4(1), 1-9

3,5-Dimethoxybenzyl bromide Raw materials

• 3,5-Dimethoxybenzyl alcohol
• Bromotrimethylsilane
• 3,5-Dimethoxybenzaldehyde

3,5-Dimethoxybenzyl bromide Preparation Products

• 3,5-Dimethoxybenzyl bromide (877-88-3)

• 1. Excess electrons in lithium–ethylamine solutions—density, electrical conductivity and EPR studies
  Phys. Chem. Chem. Phys., 1999,1, 3561-3565
• 2. Enantiocontrolled construction of sistodiolynne, an unusual polyketide from the wood-decay fungus Sistrema raduloides
  Chem. Commun., 1997, 767-768
• 3. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
• 4. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
• 5. Excellent kinetics of single-phase Gd-doped ceria fuel electrodes in solid oxide cells?
  Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Dimethoxybenzenes
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Methoxybenzenes Dimethoxybenzenes
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

• 2746-25-0(4-Methoxybenzyl bromide)
• 35047-51-9(5-(Bromomethyl)-1,3-dimethoxy-2-methyl-benzene)
• 496853-18-0(Methylium, bromo(4-methoxyphenyl)-)
• 19254-79-6(1,3-bis(Bromomethyl)-5-methoxy-Benzene)
• 874-98-6(3-Methoxybenzyl bromide)
• 51632-16-7(1-(Bromomethyl)-3-phenoxybenzene)
• 21852-50-6(5-(Bromomethyl)-1,2,3-trimethoxybenzene)
• 4542-75-0(4,4'-Oxybis((bromomethyl)benzene))
• 36881-42-2(1-(Bromomethyl)-4-phenoxybenzene)
• 106116-42-1(1-(Bromomethyl)-3-methoxy-5-methylbenzene)