Production Method 1

88284-48-4

87698-82-6

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Tetrahydrofuran ;  1 h, rt
1.2 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  4 h, rt
1.3 Reagents: Sodium carbonate Solvents: Water

Reference

Synthesis of ortho-Haloaminoarenes by Aryne Insertion of Nitrogen-Halide Bonds

Hendrick, Charles E.; et al, Journal of Organic Chemistry, 2015, 80(2), 1059-1069

Production Method 2

5765-65-1

1229227-01-3

87698-82-6

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: 1,4-Dioxane ;  20 h, 130 °C; 4 h, 130 °C

Reference

Transition-Metal-Free Electrophilic Amination of Arylboroxines

Xiao, Qing; et al, Organic Letters, 2012, 14(16), 4230-4233

Production Method 3

5414-19-7

87698-82-6

Reaction Conditions

1.1 Catalysts: N,N-Diethyl-2-propanamine

Reference

"Tert-Amino effect" in heterocyclic synthesis. Formation of N heterocycles by ring-closure reactions of substituted 2-vinyl-N,N-dialkylanilines

Verboom, Willem; et al, Journal of Organic Chemistry, 1984, 49(2), 269-76

Production Method 4

375-72-4

87698-82-6

Reaction Conditions

1.1 Reagents: Diisopropylamine Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ;  0 °C; 0 °C → rt; 12 h, rt
1.2 Solvents: Water
2.1 Reagents: Sodium tert-butoxide Catalysts: Tris(dibenzylideneacetone)dipalladium ,  BINAP Solvents: Toluene ;  rt; 24 h, 105 °C

Reference

Palladium-Catalyzed Amination of Aryl Nonaflates

Anderson, Kevin W.; et al, Journal of Organic Chemistry, 2003, 68(25), 9563-9573

Production Method 5

92-53-5

87698-82-6

30483-75-1

Reaction Conditions

1.1 Reagents: Sodium bromide ,  Hydrogen peroxide Catalysts: Benzeneseleninic acid Solvents: Diethyl ether ,  Water ;  24 h, pH 6, rt

Reference

Substituent Effects in Arylseleninic Acid-Catalyzed Bromination of Organic Substrates with Sodium Bromide and Hydrogen Peroxide

Drake, Michael D.; et al, Organometallics, 2003, 22(20), 4158-4162

Production Method 6

583-55-1

87698-82-6

Reaction Conditions

1.1 Reagents: Sodium tert-butoxide ,  18-Crown-6 Catalysts: Tris(dibenzylideneacetone)dipalladium ,  (-)-BINAP Solvents: Chloroform

Reference

Room temperature catalytic amination of aryl iodides

Wolfe, John P.; et al, Journal of Organic Chemistry, 1997, 62(17), 6066-6068

Production Method 7

87698-82-6

Reaction Conditions

1.1 Reagents: Sodium tert-butoxide Catalysts: Tris(dibenzylideneacetone)dipalladium ,  BINAP Solvents: Toluene ;  rt; 24 h, 105 °C

Reference

Palladium-Catalyzed Amination of Aryl Nonaflates

Anderson, Kevin W.; et al, Journal of Organic Chemistry, 2003, 68(25), 9563-9573

Production Method 8

87698-82-6

Reaction Conditions

1.1 Reagents: Sodium tert-butoxide Catalysts: Tris(dibenzylideneacetone)dipalladium ,  BINAP Solvents: Toluene ;  16 h, 80 °C

Reference

Palladium-catalyzed monoamination of dihalogenated benzenes

Larsen, Simon Birkso; et al, Tetrahedron, 2008, 64(13), 2938-2950

Production Method 9

88284-48-4

87698-82-6

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile ;  1 h, rt
1.2 Reagents: Cesium fluoride ;  60 °C

Reference

Insertion of Arynes into N-Halo Bonds: A Direct Approach to o-Haloaminoarenes

Hendrick, Charles E.; et al, Organic Letters, 2013, 15(13), 3444-3447

Production Method 10

87698-82-6

Reaction Conditions

1.1 Reagents: Dipotassium phosphate Solvents: Dimethylformamide ;  rt
2.1 Reagents: Potassium carbonate Solvents: 1,4-Dioxane ;  20 h, 130 °C; 4 h, 130 °C

Reference

Transition-Metal-Free Electrophilic Amination of Arylboroxines

Xiao, Qing; et al, Organic Letters, 2012, 14(16), 4230-4233

Production Method 11

244205-40-1

87698-82-6

Reaction Conditions

1.1 Solvents: Toluene ;  1.5 h, reflux
2.1 Reagents: Potassium carbonate Solvents: 1,4-Dioxane ;  20 h, 130 °C; 4 h, 130 °C

Reference

Transition-Metal-Free Electrophilic Amination of Arylboroxines

Xiao, Qing; et al, Organic Letters, 2012, 14(16), 4230-4233

Production Method 12

88284-48-4

87698-82-6

92-53-5

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile ;  1 h, rt
1.2 Reagents: Cesium fluoride ;  80 °C

Reference

Insertion of Arynes into N-Halo Bonds: A Direct Approach to o-Haloaminoarenes

Hendrick, Charles E.; et al, Organic Letters, 2013, 15(13), 3444-3447

4-(2-Bromophenyl)morpholine Raw materials

• Nonafluoro-1-butanesulfonyl Fluoride
• Bis(2-bromoethyl) ether
• 2-Bromoiodobenzene
• 4-Phenylmorpholine
• (2-Bromophenyl)boronic acid
• benzoic acid morpholin-4-yl ester
• Boroxin, 2,4,6-tris(2-bromophenyl)-
• 2-(Trimethylsilyl)phenyl trifluoromethanesulfonate

4-(2-Bromophenyl)morpholine Preparation Products

• 4-(4-Bromophenyl)morpholine (30483-75-1)
• 4-(2-Bromophenyl)morpholine (87698-82-6)
• 4-Phenylmorpholine (92-53-5)

• 1. Alumina coating on 5 V lithium cobalt fluorophosphate cathode material for lithium secondary batteries – synthesis and electrochemical properties?
  S. Amaresh,K. Karthikeyan,K. J. Kim,Y. S. Lee RSC Adv., 2014,4, 23107-23115
• 2. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
• 3. An atomic scale study of defects in Co2FeAl
  Ravi Kumar Yadav,R. Govindaraj Phys. Chem. Chem. Phys., 2020,22, 26876-26886
• 4. An approach to the structure and vibrational analysis of cis- and trans-3-chlorostyrene through IR/Raman and INS spectroscopies and theoretical ab initio/DFT calculations?
  J. M. Granadino-Roldán,M. Fernández-Gómez,A. Navarro,T. Pe?a Ruiz,U. A. Jayasooriya Phys. Chem. Chem. Phys., 2004,6, 1133-1143
• 5. An investigation on the second-order nonlinear optical response of cationic bipyridine or phenanthroline iridium(iii) complexes bearing cyclometallated 2-phenylpyridines with a triphenylamine substituent?
  David B. Cordes,Alexandra M. Z. Slawin,Stefania Righetto,Denis Jacquemin,Eli Zysman-Colman,Véronique Guerchais Dalton Trans., 2018,47, 8292-8300

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Oxazinanes Phenylmorpholines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Oxazinanes Morpholines Phenylmorpholines
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

• 88799-18-2(Morpholinium, 4-bromo-4-(4-bromophenyl)-, bromide)
• 494774-44-6(Piperazine, 1-(2-bromophenyl)-4-(2-methoxyethyl)-)
• 197846-83-6(4-(3-Bromophenyl)morpholine, Hydrochloride Salt)
• 1257665-20-5(4-(2-Bromo-5-chlorophenyl)morpholine)
• 30483-75-1(4-(4-Bromophenyl)morpholine)
• 27173-18-8(4-(3,5-Dibromophenyl)morpholine)
• 1186663-63-7(4-(4-Bromophenyl)morpholine hydrochloride)
• 197846-82-5(4-(3-Bromophenyl)morpholine)
• 88799-23-9(Morpholinium, 4-(4-bromophenyl)-4-methyl-, bromide)
• 347324-26-9(3-Bromo-4-morpholinoaniline)