Production Method 1

393-53-3

876919-08-3

Reaction Conditions

1.1 Catalysts: Sulfuric acid Solvents: Methanol ;  48 h, rt
1.2 Reagents: Sodium carbonate Solvents: Water ;  basified, rt

Reference

Accessing (Multi)Fluorinated Piperidines Using Heterogeneous Hydrogenation

Wagener, Tobias; et al, ACS Catalysis, 2020, 10(20), 12052-12057

Production Method 2

103698-10-8

876919-08-3

Reaction Conditions

1.1 Reagents: Cesium fluoride Solvents: Dimethyl sulfoxide ;  1.5 h, 120 °C

Reference

A simple synthetic route to methyl 3-fluoropyridine-4-carboxylate by nucleophilic aromatic substitution

Tjosaas, Freddy; et al, Molecules, 2006, 11(2-3), 130-133

methyl 3-fluoropyridine-4-carboxylate Raw materials

• 3-fluoropyridine-4-carboxylic acid
• Methyl 3-nitroisonicotinate

methyl 3-fluoropyridine-4-carboxylate Preparation Products

• methyl 3-fluoropyridine-4-carboxylate (876919-08-3)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids

• 1353102-03-0(methyl 2,3-difluoropyridine-4-carboxylate)
• 1803821-90-0(4-Pyridinecarboxylic acid, 3-fluoro-5-methyl-, methyl ester)
• 1256809-70-7(ethyl 3-fluoro-5-methylpyridine-4-carboxylate)
• 1214324-60-3(Methyl 3,5-difluoroisonicotinate)
• 1260784-53-9(Ethyl 3-fluoro-2-methylisonicotinate)
• 876919-10-7(Methyl 2-chloro-5-fluoroisonicotinate)
• 393-53-3(3-fluoropyridine-4-carboxylic acid)
• 885588-15-8(methyl 5-fluoro-2-methyl-pyridine-4-carboxylate)
• 903522-29-2(3,5-Difluoroisonicotinic acid)
• 343-72-6(3-fluoro-4-Pyridinecarboxylic acid ethyl ester)