Production Method 1

501-92-8

87688-90-2

Reaction Conditions

1.1 Reagents: tert-Butyl peroxide Solvents: Chlorobenzene ;  rt; 2 h, 130 °C

Reference

Development of the radical C-O coupling reaction of phenols toward the synthesis of natural products comprising a diaryl ether skeleton

Tanaka, Kumpei; et al, Tetrahedron, 2019, 75(29), 3875-3885

Production Method 2

501-92-8

87688-90-2

528-43-8

Reaction Conditions

1.1 Reagents: Hydrogen peroxide Solvents: Methanol ,  Water ;  18 min, pH 6, rt

Reference

Cytotoxic neolignans: an SAR study

Kong, Zwe-Ling; et al, Bioorganic & Medicinal Chemistry Letters, 2005, 15(1), 163-166

Production Method 3

501-92-8

87688-90-2

528-43-8

219475-49-7

139726-29-7

Reaction Conditions

1.1 Reagents: Hydrogen peroxide Catalysts: Peroxidase Solvents: Methanol ,  Water ;  pH 6, rt; 15 min, pH 6, rt
1.2 Reagents: Sodium bisulfite ;  rt
1.3 Reagents: Hydrogen ion Solvents: Water ;  acidified, rt

Reference

Peroxidase-catalyzed synthesis of neolignan and its anti-inflammatory activity

Tzeng, Shin-Cheng; et al, Journal of Molecular Catalysis B: Enzymatic, 2004, 32(1-2), 7-13

Production Method 4

501-92-8

87688-90-2

528-43-8

Reaction Conditions

1.1 Reagents: Oxygen ;  2 h, pH 4.5, 45 °C

Reference

Laccase catalyses phytophenol furanocyclic dimerization: Substrate specificity and diastereoselective process

Li, Xican ; et al, Journal of Molecular Structure, 2023, 1274,

Production Method 5

140-67-0

87688-90-2

528-43-8

Reaction Conditions

1.1 Reagents: (T-4)-Tribromo[1,1′-thiobis[methane]]boron ;  reflux
2.1 Reagents: Hydrogen peroxide Solvents: Methanol ,  Water ;  18 min, pH 6, rt

Reference

Cytotoxic neolignans: an SAR study

Kong, Zwe-Ling; et al, Bioorganic & Medicinal Chemistry Letters, 2005, 15(1), 163-166

Production Method 6

140-67-0

87688-90-2

528-43-8

219475-49-7

139726-29-7

Reaction Conditions

1.1 Reagents: (T-4)-Tribromo[1,1′-thiobis[methane]]boron Solvents: 1,2-Dichloroethane ;  1 h, reflux
1.2 Reagents: Water
2.1 Reagents: Hydrogen peroxide Catalysts: Peroxidase Solvents: Methanol ,  Water ;  pH 6, rt; 15 min, pH 6, rt
2.2 Reagents: Sodium bisulfite ;  rt
2.3 Reagents: Hydrogen ion Solvents: Water ;  acidified, rt

Reference

Peroxidase-catalyzed synthesis of neolignan and its anti-inflammatory activity

Tzeng, Shin-Cheng; et al, Journal of Molecular Catalysis B: Enzymatic, 2004, 32(1-2), 7-13

Production Method 7

501-92-8

87688-90-2

528-43-8

219475-52-2

219475-49-7

219475-53-3

139726-29-7

Reaction Conditions

1.1 Reagents: Sodium carbonate ,  Potassium ferricyanide Solvents: Water

Reference

Biomimetic Synthesis of Illicium Oligomeric Neolignans

Sy, Lai-King; et al, Journal of Chemical Research, 1998, (8), 476-477

Isomagnolol Raw materials

• Estragole
• 4-Allylphenol

Isomagnolol Preparation Products

• Magnolol (528-43-8)
• 4a,9b-Dihydro-8,9b-di-2-propen-1-yl-2-[4-(2-propen-1-yl)phenoxy]-3(4H)-dibenzofuranone (219475-52-2)
• 3(4H)-Dibenzofuranone, 4a,9b-dihydro-8,9b-di-2-propenyl- (219475-49-7)
• [1,1′:3′,1′′:3′′,1′′′-Quaterphenyl]-2,2′,2′′,2′′′-tetrol, 5,5′,5′′,5′′′-tetra-2-propenyl- (219475-53-3)
• Dunnianol (139726-29-7)
• Isomagnolol (87688-90-2)

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• 4. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
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• 5. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Diphenylethers

• 487-11-6(Elemicin)
• 18738-93-7(Benzene,2-methoxy-1-phenoxy-4-(2-propen-1-yl)-)
• 8068-83-5(N 2)
• 85187-52-6(Piperidine,[(tetrahydro-2-furanyl)methyl]- (9CI))
• 32601-56-2(Phenol, 2-methoxy-4-(2-propen-1-yl)-, zinc salt (2:1))
• 83864-78-2(Obovatol)
• 97-53-0(Eugenol)
• 93-15-2(Methyl Eugenol)
• 6627-88-9(4-allyl-2,6-dimethoxyphenol)
• 62486-66-2(Benzene, 4-(2-butenyl)-1,2-dimethoxy-, (E)-)