Production Method 1

1975-51-5

593-56-6

876343-38-3

Reaction Conditions

1.1 Reagents: Oxalyl chloride Catalysts: Dimethylformamide Solvents: Dichloromethane ;  < 5 min, 0 °C; 4 h, rt
1.2 Reagents: Potassium carbonate Solvents: Ethyl acetate ,  Water ;  12 h, rt
2.1 Reagents: Cupric acetate Catalysts: L-Alanine ,  Bis[dichloro[η5-(pentamethylcyclopentadienyl)]rhodium] ,  Silver hexafluoroantimonate Solvents: 2,2,2-Trifluoroethanol ;  24 h, 110 °C

Reference

Rhodium(III)-Catalyzed Intramolecular Benzylic C(sp 3 )-H Amidation for the Synthesis of Isoindolinones

Yang, Darun; et al, Synthesis, 2023, 55(3), 481-488

Production Method 2

1387684-86-7

876343-38-3

Reaction Conditions

1.1 Reagents: Cupric acetate Catalysts: L-Alanine ,  Bis[dichloro[η5-(pentamethylcyclopentadienyl)]rhodium] ,  Silver hexafluoroantimonate Solvents: 2,2,2-Trifluoroethanol ;  24 h, 110 °C

Reference

Rhodium(III)-Catalyzed Intramolecular Benzylic C(sp 3 )-H Amidation for the Synthesis of Isoindolinones

Yang, Darun; et al, Synthesis, 2023, 55(3), 481-488

5-Nitroisoindolin-1-one Raw materials

• 2-Methyl-4-nitrobenzoic acid
• Methoxyamine hydrochloride
• N-Methoxy-2-methyl-4-nitrobenzamide

5-Nitroisoindolin-1-one Preparation Products

• 5-Nitroisoindolin-1-one (876343-38-3)

• 1. Dissociative dynamics of O2 on Ag(110)?
  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
• 2. Excess electrons in lithium–ethylamine solutions—density, electrical conductivity and EPR studies
  Phys. Chem. Chem. Phys., 1999,1, 3561-3565
• 3. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
• 4. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 5. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Isoindoles and derivatives Isoindolones
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Isoindoles and derivatives Isoindolines Isoindolones

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