Production Method 1

393-39-5

875664-27-0

Reaction Conditions

1.1 Reagents: Bromine Solvents: Acetic acid ,  Acetic anhydride ,  Water ;  80 - 85 °C

Reference

Preparation of 1-bromo-3-fluoro-5-trifluoromethylbenzene

, China, , ,

Production Method 2

393-09-9

875664-27-0

Reaction Conditions

1.1 Reagents: Acetic acid Solvents: Water ;  30 min, reflux
1.2 90 - 95 °C; 2 h, reflux
2.1 Reagents: Bromine Solvents: Acetic acid ,  Acetic anhydride ,  Water ;  80 - 85 °C

Reference

Preparation of 1-bromo-3-fluoro-5-trifluoromethylbenzene

, China, , ,

2-Bromo-4-fluoro-6-(trifluoromethyl)aniline Raw materials

• 2-Amino-5-fluorobenzotrifluoride
• 5-Fluoro-2-nitrobenzotrifluoride

2-Bromo-4-fluoro-6-(trifluoromethyl)aniline Preparation Products

• 2-Bromo-4-fluoro-6-(trifluoromethyl)aniline (875664-27-0)

• 1. Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization.
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• 2. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
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• 3. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
• 4. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
• 5. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Trifluoromethylbenzenes
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

Professional Introduction to 2-Bromo-4-fluoro-6-(trifluoromethyl)aniline (CAS No. 875664-27-0)

2-Bromo-4-fluoro-6-(trifluoromethyl)aniline is a highly specialized organic compound that has garnered significant attention in the field of pharmaceutical chemistry and materials science. This compound, characterized by its unique structural features, plays a crucial role in the synthesis of various bioactive molecules and advanced materials. The presence of multiple halogen atoms, specifically bromo and fluoro substituents, along with a trifluoromethyl group, endows it with distinct chemical properties that make it invaluable in modern research.

The chemical formula of 2-Bromo-4-fluoro-6-(trifluoromethyl)aniline can be represented as C?H?BrF?N?. This molecular structure not only highlights its complexity but also underscores its potential utility in the development of novel compounds. The compound's aniline core provides a versatile platform for further functionalization, enabling researchers to design molecules with tailored properties for specific applications.

In recent years, the demand for halogenated aromatic compounds has surged due to their broad spectrum of biological activities and industrial applications. Among these, 2-Bromo-4-fluoro-6-(trifluoromethyl)aniline stands out due to its ability to serve as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. Its structural motifs are frequently employed in medicinal chemistry to develop inhibitors, agonists, and other therapeutic agents.

One of the most compelling aspects of 2-Bromo-4-fluoro-6-(trifluoromethyl)aniline is its role in the development of small-molecule drugs. The combination of bromine and fluoro substituents enhances the compound's reactivity, making it an excellent precursor for further chemical transformations. These transformations can lead to the creation of highly potent and selective drug candidates that target various diseases.

The trifluoromethyl group is particularly noteworthy, as it is known to improve the metabolic stability and binding affinity of drug molecules. This feature has been extensively exploited in the design of kinase inhibitors, which are critical in treating cancers and inflammatory diseases. Researchers have leveraged the reactivity of 2-Bromo-4-fluoro-6-(trifluoromethyl)aniline to develop novel inhibitors that exhibit superior pharmacological profiles compared to existing therapies.

Recent studies have also highlighted the compound's significance in materials science. The unique electronic properties imparted by the halogen substituents make 2-Bromo-4-fluoro-6-(trifluoromethyl)aniline an attractive building block for organic semiconductors and liquid crystals. These materials are essential components in advanced display technologies, photovoltaic devices, and sensors. The ability to fine-tune their properties through strategic functionalization has opened up new avenues for innovation in nanotechnology.

The synthesis of 2-Bromo-4-fluoro-6-(trifluoromethyl)aniline involves multi-step organic reactions that require precise control over reaction conditions. Advanced synthetic methodologies, such as cross-coupling reactions and palladium-catalyzed transformations, are commonly employed to achieve high yields and purity. These synthetic strategies not only highlight the compound's complexity but also showcase the ingenuity of modern synthetic chemistry.

In conclusion, 2-Bromo-4-fluoro-6-(trifluoromethyl)aniline (CAS No. 875664-27-0) is a multifaceted compound with far-reaching implications in pharmaceuticals and materials science. Its unique structural features and reactivity make it a cornerstone in the development of innovative drugs and advanced materials. As research continues to uncover new applications for this compound, its importance is set to grow even further.

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