Cas no 874285-19-5 (1-(bromomethyl)-2-chloro-3-fluorobenzene)

1-(bromomethyl)-2-chloro-3-fluorobenzene structure
874285-19-5 structure
Product Name:1-(bromomethyl)-2-chloro-3-fluorobenzene
CAS No:874285-19-5
MF:C7H5BrClF
MW:223.470003843307
MDL:MFCD09038462
CID:69195
PubChem ID:44782644
Update Time:2024-10-26

1-(bromomethyl)-2-chloro-3-fluorobenzene Chemical and Physical Properties

Names and Identifiers

    • 1-(Bromomethyl)-2-chloro-3-fluorobenzene
    • 2-Chloro-3-fluorobenzyl bromide
    • 2-chloro-3-fluorobenzylbromide
    • Benzene, 1-(bromomethyl)-2-chloro-3-fluoro-
    • KSC493Q5B
    • 3-fluoro-2-chlorobenzyl bromide
    • AQQPRCFCKCXWGZ-UHFFFAOYSA-N
    • CL8695
    • BBL101137
    • STL554933
    • PF10781
    • AS00676
    • AM62201
    • ST2415055
    • AB0010158
    • FT
    • 1-(Bromomethyl)-2-chloro-3-fluorobenzene (ACI)
    • DTXSID20660660
    • 1-Bromomethyl-2-chloro-3-fluorobenzene
    • EN300-125431
    • SCHEMBL5627142
    • W-203994
    • SY026865
    • CS-W005451
    • DB-006045
    • AKOS005257293
    • 874285-19-5
    • MFCD09038462
    • DS-15862
    • 1-(bromomethyl)-2-chloro-3-fluorobenzene
    • MDL： MFCD09038462
    • Inchi： 1S/C7H5BrClF/c8-4-5-2-1-3-6(10)7(5)9/h1-3H,4H2
    • InChI Key： AQQPRCFCKCXWGZ-UHFFFAOYSA-N
    • SMILES： FC1C(Cl)=C(CBr)C=CC=1

Computed Properties

  • Exact Mass: 221.925
  • Monoisotopic Mass: 221.925
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 10
  • Rotatable Bond Count: 1
  • Complexity: 110
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: 3.2

Experimental Properties

  • Color/Form: No data avaiable
  • Density: 1.654
  • Melting Point: No data available
  • Boiling Point: 227.1℃ at 760 mmHg
  • Flash Point: 91.1°C
  • Refractive Index: 1.561
  • Vapor Pressure: No data available

1-(bromomethyl)-2-chloro-3-fluorobenzene Security Information

1-(bromomethyl)-2-chloro-3-fluorobenzene Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd.
B839483-1g
1-(Bromomethyl)-2-chloro-3-fluorobenzene
 874285-19-5 98%
1g
 ￥86.40 2022-09-02
Fluorochem
211176-1g
1-(Bromomethyl)-2-chloro-3-fluorobenzene
 874285-19-5 95%
1g
 ￡10.00 2022-02-28
Fluorochem
211176-5g
1-(Bromomethyl)-2-chloro-3-fluorobenzene
 874285-19-5 95%
5g
 ￡44.00 2022-02-28
Fluorochem
211176-10g
1-(Bromomethyl)-2-chloro-3-fluorobenzene
 874285-19-5 95%
10g
 ￡82.00 2022-02-28
Fluorochem
211176-25g
1-(Bromomethyl)-2-chloro-3-fluorobenzene
 874285-19-5 95%
25g
 ￡177.00 2022-02-28
TRC
C427585-500mg
2-Chloro-3-fluorobenzyl Bromide
 874285-19-5
500mg
 $69.00 2023-05-18
TRC
C427585-1g
2-Chloro-3-fluorobenzyl Bromide
 874285-19-5
1g
 $ 65.00 2022-06-06
TRC
C427585-5g
2-Chloro-3-fluorobenzyl Bromide
 874285-19-5
5g
 $207.00 2023-05-18
TRC
C427585-10g
2-Chloro-3-fluorobenzyl Bromide
 874285-19-5
10g
 $385.00 2023-05-18
TRC
C427585-25g
2-Chloro-3-fluorobenzyl Bromide
 874285-19-5
25g
 $793.00 2023-05-18

1-(bromomethyl)-2-chloro-3-fluorobenzene Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Triethylamine ,  Methanesulfonyl chloride Solvents: Tetrahydrofuran ;  35 min, 0 °C; 25 min, 0 °C
1.2 Reagents: Lithium bromide Solvents: Tetrahydrofuran ;  15 min, 0 °C; 1 h, 0 °C
Reference
Quinolone Carboxylic Acids as a Novel Monoketo Acid Class of Human Immunodeficiency Virus Type 1 Integrase Inhibitors
Sato, Motohide; et al, Journal of Medicinal Chemistry, 2009, 52(15), 4869-4882

Production Method 2

Reaction Conditions
1.1 Reagents: Borane Solvents: Tetrahydrofuran ;  rt; 10 h, rt → reflux; reflux → 0 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  0 °C
2.1 Reagents: Phosphorus tribromide Solvents: Diethyl ether ;  0 °C; overnight, 0 °C → rt
Reference
Discovery of Highly Potent Liver X Receptor β Agonists
Kick, Ellen K.; et al, ACS Medicinal Chemistry Letters, 2016, 7(12), 1207-1212

Production Method 3

Reaction Conditions
1.1 Reagents: Phosphorus tribromide Solvents: Diethyl ether ;  0 °C; overnight, 0 °C → rt
Reference
Discovery of Highly Potent Liver X Receptor β Agonists
Kick, Ellen K.; et al, ACS Medicinal Chemistry Letters, 2016, 7(12), 1207-1212

Production Method 4

Reaction Conditions
1.1 Reagents: Borane Solvents: Tetrahydrofuran ;  40 min, -15 °C; -15 °C → rt; 1 h, rt; rt → 50 °C; 2 h, 50 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  0 °C; 0 °C → rt; overnight, rt
2.1 Reagents: Triethylamine ,  Methanesulfonyl chloride Solvents: Tetrahydrofuran ;  35 min, 0 °C; 25 min, 0 °C
2.2 Reagents: Lithium bromide Solvents: Tetrahydrofuran ;  15 min, 0 °C; 1 h, 0 °C
Reference
Quinolone Carboxylic Acids as a Novel Monoketo Acid Class of Human Immunodeficiency Virus Type 1 Integrase Inhibitors
Sato, Motohide; et al, Journal of Medicinal Chemistry, 2009, 52(15), 4869-4882

1-(bromomethyl)-2-chloro-3-fluorobenzene Raw materials

1-(bromomethyl)-2-chloro-3-fluorobenzene Preparation Products

1-(bromomethyl)-2-chloro-3-fluorobenzene Related Literature

Related Categories

874285-19-5 (1-(bromomethyl)-2-chloro-3-fluorobenzene) Related Products

Recommended suppliers
Zhejiang Brunova Technology Co., Ltd.
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Zhejiang Brunova Technology Co., Ltd.
Shaanxi pure crystal photoelectric technology co. LTD
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Reagent
Shaanxi pure crystal photoelectric technology co. LTD
Wuhan Comings Biotechnology Co., Ltd.
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Wuhan Comings Biotechnology Co., Ltd.
Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Suzhou Senfeida Chemical Co., Ltd
Hunan Well Medicine Synthesis Technology Co., Ltd.
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Reagent
Hunan Well Medicine Synthesis Technology Co., Ltd.