Production Method 1

27466-83-7

874-73-7

Reaction Conditions

1.1 Reagents: Pinacolborane Catalysts: Sodium triethylborohydride ;  12 h, 60 °C
1.2 Reagents: Hydrochloric acid Solvents: Diethyl ether

Reference

NaHBEt3-catalyzed HBpin hydroboration and deoxygenation of primary, secondary, and tertiary amides

Yan, Ben; et al, New Journal of Chemistry, 2023, 47(7), 3202-3206

1-(4-Bromophenyl)-N-methylmethanamine hydrochloride Raw materials

• N-Methyl 4-bromobenzamide

1-(4-Bromophenyl)-N-methylmethanamine hydrochloride Preparation Products

• 1-(4-Bromophenyl)-N-methylmethanamine hydrochloride (874-73-7)

• 1. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
  Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873
• 2. Alumina grafted SBA-15 sustainable bifunctional catalysts for direct cross-coupling of benzylic alcohols to diarylmethanes?
  Chandran Rajendran,Govindaswamy Satishkumar,Charlotte Lang,Eric M. Gaigneaux Catal. Sci. Technol., 2020,10, 2583-2592
• 3. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 4. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
  Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
• 5. Acetylcholinesterase amperometric detection system based on a cobalt(II) tetraphenylporphyrin-modified electrode
  Analyst, 1996,121, 1123-1126

• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides
• Solvents and Organic Chemicals Organic Compounds

Comprehensive Analysis of 1-(4-Bromophenyl)-N-methylmethanamine hydrochloride (CAS 874-73-7): Properties, Applications, and Industry Insights

1-(4-Bromophenyl)-N-methylmethanamine hydrochloride (CAS 874-73-7), a specialized organic compound, has garnered significant attention in pharmaceutical and chemical research due to its unique structural features. This brominated aromatic amine derivative serves as a critical intermediate in synthetic chemistry, particularly in the development of bioactive molecules. The presence of both a bromophenyl group and a methylamine hydrochloride moiety enables diverse reactivity patterns, making it valuable for cross-coupling reactions and drug discovery applications.

Recent trends in AI-assisted molecular design and high-throughput screening have amplified interest in compounds like 1-(4-Bromophenyl)-N-methylmethanamine HCl. Researchers frequently search for "CAS 874-73-7 solubility data", "synthetic routes for bromophenyl amines", and "N-methylmethanamine derivatives applications", reflecting the compound's relevance in modern chemistry. Its crystalline hydrochloride salt form enhances stability, addressing common challenges in handling aromatic amine precursors.

The compound's molecular structure optimization potential aligns with current industry demands for green chemistry alternatives. Studies highlight its utility in constructing pharmacophore models, particularly for CNS-targeting compounds. Analytical techniques such as HPLC purity testing and X-ray crystallography are commonly employed to characterize this material, with many researchers seeking "874-73-7 spectral data" for verification purposes.

In material science applications, the 4-bromophenyl moiety facilitates π-stacking interactions in polymer design, while the protonated amine group enables salt formation with various counterions. This dual functionality explains growing patent activity surrounding N-methylmethanamine derivatives in electronic materials and catalysis systems. The compound's structure-activity relationship (SAR) profile makes it particularly valuable for medicinal chemistry optimization projects.

Quality control protocols for 1-(4-Bromophenyl)-N-methylmethanamine hydrochloride emphasize residual solvent analysis and heavy metal screening, addressing regulatory requirements for GMP-grade intermediates. The scientific community continues to investigate its potential in bioconjugation chemistry, with particular interest in its amine protection/deprotection kinetics. These characteristics position CAS 874-73-7 as a versatile building block for next-generation chemical synthesis.

Emerging applications in fluorescent probe development leverage the compound's halogenated aromatic system, while its hydrogen bonding capacity enables design of molecular recognition systems. Recent publications discussing "bromophenylamine synthetic methodology" frequently reference this compound's regioselective reactivity, particularly in palladium-catalyzed transformations. These attributes contribute to its growing importance in parallel synthesis platforms for drug discovery.

Thermal analysis studies of 1-(4-Bromophenyl)-N-methylmethanamine HCl reveal excellent stability profiles, addressing industry needs for heat-resistant intermediates. The compound's hygroscopic nature necessitates proper storage conditions, a topic frequently searched as "874-73-7 handling precautions". Its compatibility with continuous flow chemistry systems further enhances its utility in modern process chemistry applications.

The electrophilic aromatic substitution potential of this compound enables diverse heterocyclic ring formations, making it valuable for library synthesis in combinatorial chemistry. Analytical method development for chiral separation of related derivatives often begins with this racemic reference standard. These applications align with current research trends toward fragment-based drug design and targeted molecular imaging agents.

Environmental fate studies of brominated aromatic compounds increasingly include derivatives like CAS 874-73-7, particularly regarding their biodegradation pathways. The compound's structure-property relationships inform predictive models for ADMET profiling, a critical consideration in preclinical development. These multidisciplinary applications underscore its importance across chemical biology and materials science research domains.

Future research directions likely will explore the compound's potential in metal-organic frameworks (MOFs) and supramolecular chemistry, capitalizing on its dual functional group architecture. The continued demand for high-purity brominated building blocks ensures ongoing interest in 1-(4-Bromophenyl)-N-methylmethanamine hydrochloride as a versatile synthetic intermediate with broad applicability across multiple scientific disciplines.

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