Production Method 1

874-23-7

Reaction Conditions

1.1 Reagents: Morpholine Catalysts: p-Toluenesulfonic acid Solvents: Toluene ;  rt → reflux; 3.5 h, reflux; reflux → rt
1.2 Reagents: Triethylamine Solvents: Chloroform ;  45 min, cooled; 1 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ;  1 h, rt → reflux; reflux → rt

Reference

Synthesis and characterization of 2-acetylcyclohexanone

Han, Feng; et al, Anhui Nongye Kexue, 2009, 37(17), 7816-7817

Production Method 2

10151-22-1

874-23-7

Reaction Conditions

1.1 Catalysts: Palladium, bis(acetonitrile)dichloro- Solvents: 1,4-Dioxane ;  12 h, rt

Reference

Development, Scope, and Mechanism of the Palladium-Catalyzed Intramolecular Hydroalkylation of 3-Butenyl β-Diketones

Qian, Hua; et al, Organometallics, 2005, 24(2), 287-301

Production Method 3

917-54-4

41302-34-5

874-23-7

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran

Reference

C-Acetylation of ketones

Huckin, Stuart N.; et al, Canadian Journal of Chemistry, 1974, 52(8), 1379-80

Production Method 4

3170-69-2

6651-36-1

874-23-7

Reaction Conditions

1.1 Reagents: Boron trifluoride

Reference

Acylation of ketone silyl enol ethers with acetyl tetrafluoroborate. Synthesis of 1,3-diketones

Kopka, Ihor; et al, Journal of Organic Chemistry, 1981, 46(19), 3771-3

Production Method 5

874-23-7

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Toluene ;  3 h, 40 °C
1.2 Solvents: Methanol ;  rt

Reference

Rh2(II)-Catalyzed Selective C(sp3)-H Bond Electrophilic Amination of Aryl Azide-Tethered 1,3-Dicarbonyl Compounds

Donthoju, Ashok; et al, Organic Letters, 2023, 25(41), 7589-7594

Production Method 6

79-20-9

874-23-7

Reaction Conditions

1.1 Reagents: Sodium hydride

Reference

Boron-catalyzed dehydrative allylation of 1,3-diketones and β-ketone esters with 1,3-diarylallyl alcohols in water

Zhang, Guo-Min; et al, RSC Advances, 2021, 11(28), 17025-17031

Production Method 7

2981-10-4

874-23-7

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  10 min, 0 °C
1.2 Solvents: Dichloromethane ;  2 h, 0 °C; 2 h, 0 °C; 3 h, 0 °C → rt; rt → 0 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ;  0 °C; 3 h, reflux

Reference

A Facile Total Synthesis of Kilogram-Scale Production of SKLB1039: A Novel and Selective Hexahydroisoquinolin-Containing EZH2 Inhibitor

Feng, Qiang; et al, Current Organic Synthesis, 2022, 19(5), 583-590

Production Method 8

874-23-7

Reaction Conditions

1.1 Reagents: Potassium fluoride Catalysts: 1-(Trimethylsiloxy)cyclohexene

Reference

Novel synthetic reactions using bis(2,2,2-trifluoroethoxy)diorganosulfuranes

Kitazume, Tomoya; et al, Bulletin of the Chemical Society of Japan, 1980, 53(7), 2064-6

Production Method 9

874-23-7

Reaction Conditions

1.1 Reagents: p-Toluenesulfonic acid Solvents: Toluene ;  overnight, 120 °C
1.2 Reagents: Water ;  rt
2.1 Reagents: Triethylamine Solvents: Dichloromethane ;  5 min, 0 °C
2.2 Solvents: Dichloromethane ;  0 °C; 30 min, 0 °C; 10 h, rt

Reference

Discovery of quinolone derivatives as antimycobacterial agents

Liu, Kun-Lin; et al, RSC Advances, 2021, 11(39), 24095-24115

Production Method 10

874-23-7

Reaction Conditions

1.1 Reagents: Sodium carbonate ,  Palladate(2-), di-μ-chlorotetrachlorodi-, sodium (1:2) Solvents: Water ;  overnight, rt

Reference

Bis(β-diketonato)- and allyl-(β-diketonato)-palladium(II) complexes: synthesis, characterization and MOCVD application

Assim, K.; et al, RSC Advances, 2016, 6(104), 102557-102569

Production Method 11

874-23-7

Reaction Conditions

1.1 Reagents: Morpholine Solvents: Toluene
1.2 -

Reference

Clay catalysis: Stork's alkylation and acylation of cyclohexanone without isolation of enamine

Hammadi, Mohamed; et al, Synthetic Communications, 1996, 26(15), 2901-2904

Production Method 12

3170-69-2

62791-22-4

874-23-7

Reaction Conditions

Reference

Acylation of ketone silyl enol ethers with acetyl tetrafluoroborate. Synthesis of 1,3-diketones

Kopka, Ihor; et al, Journal of Organic Chemistry, 1981, 46(19), 3771-3

Production Method 13

10151-22-1

874-23-7

Reaction Conditions

1.1 Catalysts: Palladium, bis(acetonitrile)dichloro- Solvents: 1,4-Dioxane ;  rt

Reference

Dichloro bis(acetonitrile) palladium

Carretero, Juan Carlos; et al, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2008, 1, 1-16

Production Method 14

874-23-7

Reaction Conditions

1.1 Catalysts: Zinc chloride ,  Silicon tetrachloride Solvents: Dichloromethane ;  5 h, 25 °C
1.2 Reagents: Sodium carbonate Solvents: Dichloromethane ,  Water ;  0 °C

Reference

Evaluation of TCS/ZnCl2 with acetic anhydride as an acetylating reagent for methylene ketones

Elmorsy, Saad S.; et al, Phosphorus, 2005, 180(1), 109-116

Production Method 15

6651-36-1

874-23-7

Reaction Conditions

1.1 Reagents: Zinc chloride ,  Water Solvents: Water

Reference

Acylation of ketone silyl enol ethers with acid chlorides. Synthesis of 1,3-diketones

Tirpak, Robin E.; et al, Journal of Organic Chemistry, 1982, 47(26), 5099-102

Production Method 16

557-99-3

6651-36-1

874-23-7

Reaction Conditions

1.1 Reagents: Boron trifluoride

Reference

Acylation of ketone silyl enol ethers with acetyl tetrafluoroborate. Synthesis of 1,3-diketones

Kopka, Ihor; et al, Journal of Organic Chemistry, 1981, 46(19), 3771-3

Production Method 17

874-23-7

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Toluene ;  rt; 3 h, 40 °C; rt
1.2 Reagents: Methanol
1.3 Reagents: Hydrochloric acid Solvents: Water ;  neutralized

Reference

Design, synthesis and biological evaluation of novel 1-methyl-3-oxo-2,3,5,6,7,8-hexahydroisoquinolins as potential EZH2 inhibitors

Zhang, Lidan; et al, RSC Advances, 2015, 5(33), 25967-25978

Production Method 18

874-23-7

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Toluene ;  0 °C → 40 °C

Reference

Assembly of multicyclic isoquinoline scaffolds from pyridines: formal total synthesis of fredericamycin A

Wang, Fang-Xin; et al, Chemical Science, 2021, 12(30), 10259-10265

Production Method 19

67696-25-7

874-23-7

Reaction Conditions

1.1 Catalysts: 1-(Trimethylsiloxy)cyclohexene

Reference

Novel synthetic reactions using bis(2,2,2-trifluoroethoxy)triphenylphosphorane

Kubota, Toshio; et al, Journal of Organic Chemistry, 1980, 45(25), 5052-7

Production Method 20

18162-48-6

874-23-7

Reaction Conditions

1.1 Catalysts: Lithium diisopropylamide
2.1 -

Reference

Acylation of ketone silyl enol ethers with acetyl tetrafluoroborate. Synthesis of 1,3-diketones

Kopka, Ihor; et al, Journal of Organic Chemistry, 1981, 46(19), 3771-3

2-acetylcyclohexan-1-one Raw materials

• tert-butyl(chloro)dimethylsilane
• 7-Octene-2,4-dione
• BIS(2,2,2-TRIFLUOROETHOXY)TRIPHENYLPHOSPHORANE
• Acetyl fluoride
• Ethyl, 1-oxo- (9CI)
• 1-(Cyclohex-1-en-1-yl)piperidine
• Methyllithium (1.6M in Diethyl Ether)
• Methyl acetate
• Methyl 2-oxocyclohexanecarboxylate
• 1-(Trimethylsiloxy)cyclohexene
• Silane, (1-cyclohexen-1-yloxy)(1,1-dimethylethyl)dimethyl-

2-acetylcyclohexan-1-one Preparation Products

• 2-acetylcyclohexan-1-one (874-23-7)

• 1. An integrated system for field analysis of Cd(ii) and Pb(ii) via preconcentration using nano-TiO2/cellulose paper composite and subsequent detection with a portable X-ray fluorescence spectrometer?
  Xiaofeng Lin RSC Adv., 2016,6, 9002-9006
• 2. Aluminium alkyl and aryloxide complexes of pyrazine and bipyridines: synthesis and structure?
  Doug Ogrin,Laura H. van Poppel,Simon G. Bott,Andrew R. Barron Dalton Trans., 2004, 3689-3694
• 3. An insight into the origin of room-temperature ferromagnetism in SnO2 and Mn-doped SnO2 quantum dots: an experimental and DFT approach?
  Dhamodaran Manikandan,S. Amirthapandian,I. S. Zhidkov,A. I. Kukharenko,S. O. Cholakh,Ramaswamy Murugan Phys. Chem. Chem. Phys., 2018,20, 6500-6514
• 4. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
• 5. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977

• Solvents and Organic Chemicals Organic Compounds Aldehyde/Ketone
• Solvents and Organic Chemicals Organic Compounds

• 35049-76-4(2-(2-Methylpropanoyl)cyclohexane-1,3,5-trione)
• 14208-97-0(1,6-Hexanedione, 1,6-bis(2-oxocyclohexyl)-)
• 125296-37-9(1,3-Cyclohexanedione, 2-acetyl-4-ethyl-)
• 110501-29-6(1,3-CYCLOHEXANEDIONE, 2-(1-OXODODECYL)-)
• 53472-34-7(1,3-CYCLOHEXANEDIONE, 2-(3-OXOHEXYL)-)
• 22122-93-6(2-Hexanoylcyclohexan-1-one)
• 63055-14-1(1,3(2H,4H)-NAPHTHALENEDIONE, HEXAHYDRO-, CIS-)
• 861538-72-9(2,4,6-triacetyl-cyclohexane-1,3,5-trione)
• 63055-15-2((4aS,8aR)-Hexahydronaphthalene-1,3(2H,4H)-dione)
• 20117-72-0(5-methyl-2-[(4-methyl-2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione)