Production Method 1

873-55-2

Reaction Conditions

1.1 Reagents: Sodium bicarbonate ,  Sodium sulfite Solvents: Water ;  4 h, rt → 80 °C

Reference

Design, synthesis and biological evaluation of phenyl vinyl sulfone based NLRP3 inflammasome inhibitors

Zhang, Xiangna; et al, Bioorganic Chemistry, 2022, 128,

Production Method 2

14874-70-5

10182-84-0

873-55-2

Reaction Conditions

1.1 Reagents: Rongalite Catalysts: Iron chloride (FeCl3) Solvents: Dimethylformamide ,  Acetonitrile ;  20 min, rt

Reference

Iron-catalyzed synthesis of arylsulfinates through radical coupling reaction

Zhang, Weixi; et al, Chemical Communications (Cambridge, 2016, 52(14), 2980-2983

Production Method 3

2927905-39-1

873-55-2

Reaction Conditions

1.1 Reagents: Sodium methoxide Solvents: Methanol ;  5 min, 0 °C; 30 min, rt

Reference

Facile access to sodium arylsulfinates via nucleophilic C-S bond cleavage of 2-(arylsulfonyl)pyrimidines

Kwon, Yujeong; et al, Tetrahedron Letters, 2023, 123,

Production Method 4

873-55-2

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ;  1 h, -78 °C
1.2 Reagents: 1,4-Diazoniabicyclo[2.2.2]octane, 1,4-disulfino-, bis(inner salt) ;  -78 °C; 3 h, -78 °C; -78 °C → rt
1.3 Reagents: Sodium carbonate Solvents: Water ;  rt

Reference

Synthesis of sodium aryl sulfinates from aryl bromides employing 1,4-diazabicyclo[2.2.2]octane bis(sulfur dioxide) adduct (DABSO) as a bench-stable, gas-free alternative to SO2

Skillinghaug, Bobo; et al, Tetrahedron Letters, 2016, 57(5), 533-536

Production Method 5

10182-84-0

37181-39-8

873-55-2

Reaction Conditions

1.1 Reagents: Rongalite Catalysts: Iron chloride (FeCl3) Solvents: Dimethylformamide ;  20 min, rt

Reference

Iron-catalyzed synthesis of arylsulfinates through radical coupling reaction

Zhang, Weixi; et al, Chemical Communications (Cambridge, 2016, 52(14), 2980-2983

Production Method 6

873-55-2

Reaction Conditions

1.1 Reagents: Magnesium ,  Iodine Solvents: Tetrahydrofuran ;  1 h, 100 °C
1.2 Reagents: 1,4-Diazoniabicyclo[2.2.2]octane, 1,4-disulfino-, bis(inner salt) ;  0 °C; 3 h, 0 °C; 0 °C → rt
1.3 Reagents: Sodium carbonate Solvents: Water ;  rt
1.4 Reagents: Sulfuric acid Solvents: Water ;  acidified, cooled

Reference

Synthesis of sodium aryl sulfinates from aryl bromides employing 1,4-diazabicyclo[2.2.2]octane bis(sulfur dioxide) adduct (DABSO) as a bench-stable, gas-free alternative to SO2

Skillinghaug, Bobo; et al, Tetrahedron Letters, 2016, 57(5), 533-536

Production Method 7

10154-72-0

873-55-2

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Methanol ,  Dichloromethane ;  0 °C

Reference

Copper Mediated C(sp2)-H sulfonylation of aldehydes using a catalytic transient imine directing group

Higham, Joe I.; et al, ChemRxiv, 2021, 1, 1-6

Production Method 8

873-55-2

Reaction Conditions

1.1 Reagents: Potassium chloride ,  Potassium peroxymonosulfate sulfate (2KHSO5.KHSO4.K2SO4) Solvents: Water ;  2 h, rt
2.1 Reagents: Sodium bicarbonate ,  Sodium sulfite Solvents: Water ;  3 h, reflux

Reference

The Photochemical Activity of a Halogen-Bonded Complex Enables the Microfluidic Light-Driven Alkylation of Phenols

Cuadros, Sara; et al, Organic Letters, 2022, 24(16), 2961-2966

Production Method 9

873-55-2

Reaction Conditions

1.1 Reagents: Potassium chloride ,  Potassium peroxymonosulfate sulfate (2KHSO5.KHSO4.K2SO4) Solvents: Water ;  60 °C
2.1 Reagents: Sodium bicarbonate ,  Sodium sulfite Solvents: Water ;  4 h, 80 °C

Reference

A radical cyclization cascade of 2-alkynylbenzonitriles with sodium arylsulfinates

Zhou, Bang; et al, Organic & Biomolecular Chemistry, 2018, 16(42), 7959-7963

Production Method 10

24040-12-8

873-55-2

Reaction Conditions

1.1 Catalysts: Ethyl cyanoacetate

Reference

Reaction of thiosulfonic acid esters with ethyl cyanoacetate in the presence of alcoholates

Bilozor, T. K.; et al, Zhurnal Organicheskoi Khimii, 1984, 20(4), 889-90

Production Method 11

24244-60-8

873-55-2

Reaction Conditions

1.1 Reagents: Sodium ethoxide Solvents: Ethanol

Reference

A convenient preparation of sulfinic acids by the reaction of 2-sulfonylpyridines and their N-oxides with nucleophiles

Furukawa, Naomichi; et al, Heterocycles, 1986, 24(11), 3019-22

Production Method 12

24244-60-8

873-55-2

Reaction Conditions

1.1 Catalysts: Sodium ethoxide

Reference

ipso-Substitution of a sulfinyl or sulfonyl group attached to pyridine rings and its application for the synthesis of macrocycles

Furukawa, Naomichi; et al, Journal of the Chemical Society, 1984, (8), 1839-45

Production Method 13

4972-29-6

873-55-2

Reaction Conditions

1.1 rt

Reference

Base-Mediated C4-Selective C-H-Sulfonylation of Pyridine

Friedrich, Marius; et al, European Journal of Organic Chemistry, 2022, 2022(34),

Production Method 14

52778-10-6

873-55-2

Reaction Conditions

Reference

Chemistry of the sulfur-nitrogen bond. 14. Arenesulfenic acids from N-alkylidenearenesulfinamides (sulfinimines)

Davis, Franklin A.; et al, Journal of the American Chemical Society, 1978, 100(9), 2844-52

Production Method 15

52736-48-8

873-55-2

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Tetrahydrofuran ,  Water ;  25 h, 25 °C

Reference

Iodide-Catalyzed Synthesis of Secondary Thiocarbamates from Isocyanides and Thiosulfonates

Mampuys, Pieter; et al, Organic Letters, 2016, 18(12), 2808-2811

Production Method 16

100-59-4

873-55-2

Reaction Conditions

1.1 Reagents: 1,4-Diazoniabicyclo[2.2.2]octane, 1,4-disulfino-, bis(inner salt) ;  0 °C; 3 h, 0 °C; 0 °C → rt
1.2 Reagents: Sodium carbonate Solvents: Water ;  rt
1.3 Reagents: Sulfuric acid Solvents: Water ;  acidified, cooled

Reference

Synthesis of sodium aryl sulfinates from aryl bromides employing 1,4-diazabicyclo[2.2.2]octane bis(sulfur dioxide) adduct (DABSO) as a bench-stable, gas-free alternative to SO2

Skillinghaug, Bobo; et al, Tetrahedron Letters, 2016, 57(5), 533-536

Production Method 17

14080-17-2

873-55-2

Reaction Conditions

1.1 Reagents: Sodium methoxide Solvents: Methanol ;  5 min, 0 °C; 30 min, rt

Reference

Facile access to sodium arylsulfinates via nucleophilic C-S bond cleavage of 2-(arylsulfonyl)pyrimidines

Kwon, Yujeong; et al, Tetrahedron Letters, 2023, 123,

Production Method 18

2927905-62-0

873-55-2

Reaction Conditions

1.1 Reagents: Sodium ethoxide Solvents: Ethanol ;  5 min, 0 °C; 30 min, rt

Reference

Facile access to sodium arylsulfinates via nucleophilic C-S bond cleavage of 2-(arylsulfonyl)pyrimidines

Kwon, Yujeong; et al, Tetrahedron Letters, 2023, 123,

Production Method 19

16722-51-3

10182-84-0

873-55-2

Reaction Conditions

1.1 Reagents: Rongalite Catalysts: Iron chloride (FeCl3) Solvents: Dimethylformamide ;  20 min, rt

Reference

Iron-catalyzed synthesis of arylsulfinates through radical coupling reaction

Zhang, Weixi; et al, Chemical Communications (Cambridge, 2016, 52(14), 2980-2983

Production Method 20

591-50-4

873-55-2

Reaction Conditions

1.1 Reagents: Magnesium ,  Iodine Solvents: Tetrahydrofuran ;  1 h, 100 °C
1.2 Reagents: 1,4-Diazoniabicyclo[2.2.2]octane, 1,4-disulfino-, bis(inner salt) ;  0 °C; 3 h, 0 °C; 0 °C → rt
1.3 Reagents: Sodium carbonate Solvents: Water ;  rt
1.4 Reagents: Sulfuric acid Solvents: Water ;  acidified, cooled

Reference

Synthesis of sodium aryl sulfinates from aryl bromides employing 1,4-diazabicyclo[2.2.2]octane bis(sulfur dioxide) adduct (DABSO) as a bench-stable, gas-free alternative to SO2

Skillinghaug, Bobo; et al, Tetrahedron Letters, 2016, 57(5), 533-536

Production Method 21

873-55-2

Reaction Conditions

1.1 Reagents: Methyl acrylate Catalysts: Sodium acetate Solvents: Tetrahydrofuran ,  Water ;  18 h, rt
1.2 Reagents: m-Chloroperbenzoic acid Solvents: Dichloromethane ;  rt
1.3 Reagents: Sodium hydroxide Solvents: Water ;  rt
1.4 Reagents: Sodium hydroxide Solvents: Methanol ,  Dichloromethane ;  0 °C

Reference

Amine-Catalyzed Copper-Mediated C-H Sulfonylation of Benzaldehydes via a Transient Imine Directing Group

Higham, Joe I. ; et al, Angewandte Chemie, 2022, 61(27),

Production Method 22

24040-12-8

873-55-2

Reaction Conditions

1.1 Catalysts: Sodium ethoxide

Reference

Study of thiosulfonic acids. XXXII. Reaction of aryl esters of thiosulfonic acids with substances containing an active methylene group

Boldyrev, B. G.; et al, Zhurnal Organicheskoi Khimii, 1984, 20(6), 1276-83

Production Method 23

31515-43-2

873-55-2

Reaction Conditions

1.1 Catalysts: Thiophenol

Reference

A method of producing alkali metal benzenesulfinates

, European Patent Organization, , ,

Production Method 24

39574-20-4

873-55-2

Reaction Conditions

Reference

Organic sulfinic acid salts

, Japan, , ,

Production Method 25

4972-29-6

873-55-2

Reaction Conditions

Reference

Reaction of organic sulfur compounds with superoxide anion. III. Oxidation of organic sulfur compounds to sulfinic and sulfonic acids

Oae, Shigeru; et al, Tetrahedron, 1981, 37(1), 37-44

Benzenesulfinic acid, sodium salt Raw materials

• Iodobenzene
• BENZENESULFINYL CHLORIDE
• Propanoic acid, 3-(phenylsulfonyl)-, methyl ester
• Borate(1-),tetrafluoro-
• Phenylmagnesium chloride
• BENZENESULFINAMIDE, N-(PHENYLMETHYLENE)-
• Benzenesulfonic acid,4-methyl-, ion(1-)
• 2-(Phenylsulfonyl)pyridine
• Pyrimidine, 2-(phenylsulfonyl)-
• 5-Pyrimidinecarboxylic acid, 4-methyl-6-phenyl-2-(phenylsulfonyl)-, ethyl ester
• Benzenesulfonothioic acid, S-(2,4-dinitrophenyl) ester
• Benzenesulfinic acid, 1-methylethyl ester
• 2-Nitrophenyl phenyl sulfone
• Iodonium, diphenyl-
• Pyrimidine, 4,5,6-trimethyl-2-(phenylsulfonyl)-

Benzenesulfinic acid, sodium salt Preparation Products

• Benzenesulfinic acid, sodium salt (873-55-2)

• 1. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 2. Distinctive size effects of Pt nanoparticles immobilized on Fe3O4@PPy used as an efficient recyclable catalyst for benzylic alcohol aerobic oxidation and hydrogenation reduction of nitroaromatics
  Yu Long,Bing Yuan,Jianrui Niu,Xin Tong,Jiantai Ma New J. Chem., 2015,39, 1179-1185
• 3. Fe3O4/PEG-SO3H as a heterogeneous and magnetically-recyclable nanocatalyst for the oxidation of sulfides to sulfones or sulfoxides
  Saeideh Mirfakhraei,Malak Hekmati,Fereshteh Hosseini Eshbala,Hojat Veisi New J. Chem., 2018,42, 1757-1761
• 4. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 5. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzene and substituted derivatives
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives
• Solvents and Organic Chemicals Organic Compounds Acids/Esters
• Catalysts and Inorganic Chemicals Inorganic Compounds Salt

• 64586-62-5(Copper(II) benzenesulfinate hydrate)
• 515-42-4(Sodium benzenesulfonate)
• 24308-84-7(Benzenesulfinic acid;zinc)
• 824-79-3(Sodium toluene-4-sulphinate)
• 613-49-0(2-Naphthalenesulfinic acid)
• 207801-20-5(Sodium p-toluenesulfinate)
• 31984-70-0(Benzenesulfonic acid,4-mercapto-, sodium salt (1:1))
• 618-41-7(Benzenesulfinic acid)
• 25932-11-0(Sodiumbenzenesulfinatedihydrate)
• 62283-33-4(Copper, bis(phenylsulfonyl)-)