Production Method 1

765-30-0

99-05-8

871673-24-4

Reaction Conditions

1.1 Reagents: 1-Hydroxybenzotriazole ,  Diisopropylethylamine ,  1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride Solvents: Dimethylformamide ;  overnight, rt

Reference

Targeting the Kv11.1 (hERG) channel with allosteric modulators. Synthesis and biological evaluation of three novel series of LUF7346 derivatives

van Veldhoven, Jacobus P. D.; et al, European Journal of Medicinal Chemistry, 2021, 212,

Production Method 2

392709-17-0

871673-24-4

Reaction Conditions

1.1 Reagents: Stannous chloride Solvents: Ethanol ;  2 h, rt → 100 °C

Reference

Pyrrolo[3,2-b]quinoxaline Derivatives as Types I1/2 and II Eph Tyrosine Kinase Inhibitors: Structure-Based Design, Synthesis, and in Vivo Validation

Unzue, Andrea; et al, Journal of Medicinal Chemistry, 2014, 57(15), 6834-6844

Production Method 3

392709-17-0

871673-24-4

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  24 h, rt

Reference

Discovery and biological evaluation of 4,6-pyrimidine analogues with potential anticancer agents as novel colchicine binding site inhibitors

Zhang, Jifa; et al, European Journal of Medicinal Chemistry, 2023, 248,

Production Method 4

765-30-0

111331-82-9

871673-24-4

Reaction Conditions

1.1 Reagents: Diisopropylethylamine ,  Propylphosphonic anhydride Solvents: Dichloromethane ,  Ethyl acetate ;  10 min, rt
1.2 overnight, rt
2.1 Reagents: Hydrochloric acid Solvents: Dichloromethane ,  1,4-Dioxane ;  72 h, rt

Reference

Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors

Thomas, Michael G.; et al, Journal of Medicinal Chemistry, 2023, 66(15), 10413-10431

Production Method 5

923154-01-2

871673-24-4

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Dichloromethane ,  1,4-Dioxane ;  72 h, rt

Reference

Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors

Thomas, Michael G.; et al, Journal of Medicinal Chemistry, 2023, 66(15), 10413-10431

Production Method 6

765-30-0

99-05-8

871673-24-4

Reaction Conditions

1.1 Reagents: 1-Hydroxybenzotriazole ,  Diisopropylethylamine ,  1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride Solvents: Dimethylformamide ;  8 h, rt

Reference

Synthesis and bioactivity of novel adamantyl derivatives as potent MDR reversal agents

Naik, Ravi; et al, Bulletin of the Korean Chemical Society, 2011, 32(12), 4444-4446

Production Method 7

765-30-0

871673-24-4

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  0 °C; 3 h, rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  rt
2.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  24 h, rt

Reference

Discovery and biological evaluation of 4,6-pyrimidine analogues with potential anticancer agents as novel colchicine binding site inhibitors

Zhang, Jifa; et al, European Journal of Medicinal Chemistry, 2023, 248,

Production Method 8

765-30-0

871673-24-4

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  15 h, 25 °C
2.1 Reagents: Stannous chloride Solvents: Ethanol ;  2 h, rt → 100 °C

Reference

Pyrrolo[3,2-b]quinoxaline Derivatives as Types I1/2 and II Eph Tyrosine Kinase Inhibitors: Structure-Based Design, Synthesis, and in Vivo Validation

Unzue, Andrea; et al, Journal of Medicinal Chemistry, 2014, 57(15), 6834-6844

3-Amino-N-cyclopropylbenzamide Raw materials

• N-cyclopropyl-3-nitrobenzamide
• Tert-butyl (3-(cyclopropylcarbamoyl)phenyl)carbamate
• cyclopropanamine
• 3-Aminobenzoic acid
• Boc-3-Abz-OH

3-Amino-N-cyclopropylbenzamide Preparation Products

• 3-Amino-N-cyclopropylbenzamide (871673-24-4)

• 1. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 2. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
• 3. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
• 4. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 5. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
  Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Aminobenzoic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Aminobenzoic acids and derivatives

• 313524-32-2(4-amino-N-(butan-2-yl)benzamide)
• 54977-91-2(3-Amino-N-benzylbenzamide)
• 38681-77-5(N-Cyclopropyl 4-Aminobenzamide)
• 25900-62-3(3-amino-N-tert-butylbenzamide)
• 774-67-4(4-amino-N-(propan-2-yl)benzamide)
• 81882-62-4(3-Amino-N-isopropylbenzamide)
• 81882-78-2(3-Amino-N-propylbenzamide)
• 727674-35-3(1,3-Benzenedicarboxamide,5-amino-N1,N3-dicyclopropyl-)
• 6837-99-6(3-Amino-N-butylbenzamide)
• 623155-19-1(3-Amino-N-cyclopropyl-4-methylbenzamide)