Production Method 1

69-72-7

60-12-8

87-22-9

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: stereoisomer of Bis(η5-2,4-cyclopentadien-1-yl)(tetrahydrofuran)bis(1,1,1-triflu… Solvents: (Trifluoromethyl)benzene ;  24 h, 80 °C

Reference

Kinetic Analysis as an Optimization Tool for Catalytic Esterification with a Moisture-Tolerant Zirconium Complex

Villo, Piret; et al, Journal of Organic Chemistry, 2020, 85(11), 6959-6969

Phenethylsalicylate Raw materials

• Salicylic acid
• 2-Phenylethanol

Phenethylsalicylate Preparation Products

• Phenethylsalicylate (87-22-9)

• 1. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 2. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 3. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 4. Fe3O4 nanosphere@microporous organic networks: enhanced anode performances in lithium ion batteries through carbonization?
  Byungho Lim,Jaewon Jin,Jin Yoo,Seung Yong Han,Kyeongyeol Kim,Sungah Kang,Nojin Park,Sang Moon Lee,Hae Jin Kim,Seung Uk Son Chem. Commun., 2014,50, 7723-7726
• 5. Estimates of hydride ion stability in condensed systems: energy of formation and solvation in aqueous and polar-organic solvents
  Craig A. Kelly,David R. Rosseinsky Phys. Chem. Chem. Phys., 2001,3, 2086-2090

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives o-Hydroxybenzoic acid esters
• Natural Products and Extracts Flavors and Fragrances Essential Oils

Phenethylsalicylate (CAS 87-22-9): A Comprehensive Guide to Properties, Applications, and Market Trends

Phenethylsalicylate (CAS 87-22-9), also known as 2-phenylethyl salicylate, is an organic ester compound widely used in the fragrance and flavor industries. This versatile chemical combines the aromatic properties of phenethyl alcohol with the therapeutic characteristics of salicylic acid, making it valuable for various applications. With growing consumer interest in natural fragrance alternatives and cosmetic ingredients, Phenethylsalicylate has gained attention for its unique properties and benefits.

The chemical structure of Phenethylsalicylate features a benzene ring attached to an ethyl group, which is esterified with salicylic acid. This configuration gives the compound its distinctive floral, balsamic aroma with subtle spicy undertones, often described as reminiscent of honey or hyacinth. In recent years, searches for "long-lasting floral fragrances" and "skin-friendly perfume ingredients" have increased significantly, highlighting the relevance of compounds like Phenethylsalicylate in modern formulations.

One of the primary applications of Phenethylsalicylate is in the perfume industry, where it serves as a fixative agent to prolong fragrance longevity. Its ability to blend well with other aromatic compounds makes it particularly valuable in creating complex floral bouquets and oriental scent profiles. The compound's stability and low volatility contribute to its effectiveness as a fragrance base note, addressing the common consumer concern about "how to make perfume last longer."

In addition to its olfactory applications, Phenethylsalicylate finds use in cosmetic formulations and personal care products. The compound's relationship to salicylic acid gives it potential benefits for skin care, aligning with current trends toward "multifunctional cosmetic ingredients." While not as potent as pure salicylic acid, Phenethylsalicylate may offer mild skin-conditioning properties, making it suitable for products like lotions and creams where both fragrance and skin benefits are desired.

The flavor industry also utilizes Phenethylsalicylate as a flavoring agent, particularly in products requiring a sweet, floral note. Its application in food products is carefully regulated, with usage levels typically kept low due to its potent flavor characteristics. Recent interest in "natural flavor enhancers" and "clean label ingredients" has led to renewed examination of compounds like Phenethylsalicylate that can provide distinctive flavors at minimal concentrations.

From a chemical perspective, Phenethylsalicylate demonstrates excellent stability under normal storage conditions. Its hydrolysis resistance and oxidation stability make it particularly suitable for products requiring long shelf lives. These properties respond to frequent industry searches about "stable fragrance ingredients" and "how to prevent perfume degradation." The compound typically appears as a colorless to pale yellow liquid with a characteristic sweet, floral odor.

The global market for Phenethylsalicylate has shown steady growth, driven by increasing demand in the personal care industry and expanding applications in fine fragrance formulations. Market analysts note particular interest in Asia-Pacific regions, where rising disposable incomes have fueled growth in premium fragrance products. Industry reports frequently cite "floral fragrance market trends" and "growth of niche perfumery" as key factors influencing demand for specialized ingredients like Phenethylsalicylate.

Quality specifications for Phenethylsalicylate typically include parameters such as purity (usually ≥98%), refractive index, and specific gravity. Manufacturers and suppliers often emphasize these quality markers in response to buyer inquiries about "how to identify high-quality fragrance ingredients." The compound is generally recognized as safe when used appropriately, though proper handling procedures should always be followed in industrial settings.

Innovative applications for Phenethylsalicylate continue to emerge, particularly in the realm of functional fragrances and aromatherapy products. Some researchers are exploring its potential in mood-enhancing formulations, capitalizing on the growing interest in "fragrances for wellbeing" and "scent and emotional health." While these applications require further study, they demonstrate the compound's versatility beyond traditional uses.

Environmental considerations have become increasingly important in the fragrance industry, and Phenethylsalicylate scores favorably in this regard. The compound is biodegradable and does not bioaccumulate, addressing concerns about "eco-friendly fragrance ingredients" and "sustainable perfumery." Its production process has also seen improvements in recent years to reduce environmental impact, responding to industry demands for "green chemistry in fragrance."

For formulators working with Phenethylsalicylate, compatibility with other ingredients is generally excellent. The compound blends well with a wide range of essential oils and synthetic aromatics, making it versatile for various fragrance types. This characteristic answers common formulation questions like "best floral note fixatives" and "how to balance fragrance compositions." Its moderate tenacity makes it suitable for both fine fragrances and functional products.

Regulatory status for Phenethylsalicylate varies by region and application. In cosmetic use, it is generally approved within specified concentration limits. The fragrance industry's self-regulatory bodies include it on approved substance lists, providing assurance to manufacturers concerned about "IFRA compliance" and "cosmetic ingredient regulations." Always consult current regulations for specific applications and markets.

The future outlook for Phenethylsalicylate appears positive, with continued demand expected in traditional applications and potential growth in innovative uses. As consumers increasingly seek "unique fragrance experiences" and "multifunctional cosmetic ingredients," compounds like Phenethylsalicylate that offer both aromatic and potential skin benefits may see expanded use. Ongoing research into its properties and applications will likely reveal additional opportunities for this versatile ester compound.

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