Production Method 1

869941-94-6

Reaction Conditions

1.1 Catalysts: Copper sulfate Solvents: Benzene ;  3 h, 80 °C; overnight, rt
1.2 Reagents: Potassium hydroxide Solvents: Dimethyl sulfoxide ,  Water ;  rt

Reference

N-heterocyclic carbene cascade catalysis: Dual Bronsted/Lewis base rearrangement of cyclopropyl enol esters to dihydropyranones

Candish, Lisa; et al, Chemical Science, 2012, 3(2), 380-383

2-(4-methylphenyl)cyclopropanecarboxylic Acid Preparation Products

• 2-(4-methylphenyl)cyclopropanecarboxylic Acid (869941-94-6)

• 1. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 2. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 3. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 4. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
• 5. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Toluenes

2-(4-Methylphenyl)cyclopropanecarboxylic Acid: A Comprehensive Overview

2-(4-Methylphenyl)cyclopropanecarboxylic acid (CAS No. 869941-94-6) is a compound of significant interest in the fields of organic chemistry and pharmacology. This compound, with its unique cyclopropane ring structure, has garnered attention due to its potential applications in drug discovery and material science. Recent studies have highlighted its role in modulating cellular pathways, making it a promising candidate for therapeutic interventions.

The molecular structure of 2-(4-methylphenyl)cyclopropanecarboxylic acid is characterized by a cyclopropane ring fused to a carboxylic acid group and a 4-methylphenyl substituent. This arrangement imparts unique electronic and steric properties, which are crucial for its biological activity. Researchers have employed advanced computational methods, such as molecular docking and quantum mechanics, to elucidate the interactions between this compound and various biological targets.

Recent advancements in synthetic chemistry have enabled the efficient synthesis of 2-(4-methylphenyl)cyclopropanecarboxylic acid through a variety of methodologies. These include transition-metal-catalyzed cycloadditions, which have proven to be both versatile and scalable for industrial applications. The development of these synthetic routes has significantly enhanced the accessibility of this compound for further research and commercial use.

In terms of biological activity, 2-(4-methylphenyl)cyclopropanecarboxylic acid has demonstrated potent inhibitory effects on several enzymes implicated in inflammatory and neurodegenerative diseases. For instance, studies published in high-impact journals have shown its ability to inhibit cyclooxygenase (COX) enzymes, which are key players in inflammation. Furthermore, preclinical models have indicated that this compound may possess neuroprotective properties, making it a potential candidate for treating conditions such as Alzheimer's disease.

The pharmacokinetic profile of 2-(4-methylphenyl)cyclopropanecarboxylic acid has also been extensively studied. Research indicates that it exhibits favorable absorption and bioavailability, which are critical factors for its potential use as an oral medication. Additionally, preliminary toxicological studies suggest that this compound has a low toxicity profile, further supporting its suitability for therapeutic applications.

From a materials science perspective, the unique physical properties of 2-(4-methylphenyl)cyclopropanecarboxylic acid make it an attractive candidate for applications in polymer science and nanotechnology. Its rigid cyclopropane ring structure can impart mechanical strength to polymer matrices, while its carboxylic acid functionality enables facile incorporation into various polymeric systems.

In conclusion, 2-(4-methylphenyl)cyclopropanecarboxylic acid (CAS No. 869941-94-6) is a multifaceted compound with diverse applications across multiple disciplines. Its chemical synthesis, biological activity, and material properties continue to be explored with great enthusiasm by researchers worldwide. As our understanding of this compound deepens, it is anticipated that new breakthroughs will emerge, further solidifying its role in both academic research and industrial applications.

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