Cas no 869681-70-9 ((3R)-4-[(tert-butoxy)carbonyl]morpholine-3-carboxylic acid)

(3R)-4-[(tert-butoxy)carbonyl]morpholine-3-carboxylic acid structure
869681-70-9 structure
Product Name:(3R)-4-[(tert-butoxy)carbonyl]morpholine-3-carboxylic acid
CAS No:869681-70-9
MF:C10H17NO5
MW:231.245683431625
MDL:MFCD04114909
CID:69136
PubChem ID:1512538
Update Time:2024-10-26

(3R)-4-[(tert-butoxy)carbonyl]morpholine-3-carboxylic acid Chemical and Physical Properties

Names and Identifiers

    • (R)-4-(tert-Butoxycarbonyl)morpholine-3-carboxylic acid
    • (R)-Morpholine-3,4-dicarboxylic acid 4-tert-butyl ester
    • (3r)-4-[(2-methylpropan-2-yl)oxycarbonyl]morpholine-3-carboxylic Acid
    • (R)-N-Boc-morpholine-3-carboxylic acid
    • 4-Boc-3(R)-morpholinecarboxylic acid
    • (r)-4-boc-morpholine-3-carboxylic acid
    • (R)-4-Boc-morpholine-3-carboxylicacid
    • (r)-4-n-boc-3-morpholinecarboxylic acid
    • (R)-4-Boc-morpholine-3-carboxylic acid, AldrichCPR
    • (R)-Morpholine-3,4-dicarboxylic acid 4-tert-butylester
    • KVXXEKIGMOEPSA-SSDOTTSWSA-N
    • BH059
    • (3R)-4-[(tert-butoxy)carbonyl]morpholine-3-carboxylic acid
    • 4-(1,1-Dimethylethyl) (3R)-3,4-morpholinedicarboxylate (ACI)
    • DTXSID10363714
    • EN300-159831
    • DS-12719
    • CS-W019728
    • AC-9323
    • MFCD04114909
    • (r)-4-(tert-butoxycarbonyl)morpholine-3-carboxylicacid
    • (R)-morpholine-3,4-dicarboxylic acid-4-tert-butyl ester
    • (R)-4-tert-Butyloxycarbonyl-3-morpholine carboxylic acid
    • 4-Boc-(3R)-morpholinecarboxylic acid
    • (R)-N-BOC-MORPHOLINE-3CARBOXYLIC ACID
    • (3R)-4-(TERT-BUTOXYCARBONYL)MORPHOLINE-3-CARBOXYLIC ACID
    • 869681-70-9
    • (3R)-4-{[(1,1-dimethylethyl)oxy]carbonyl}-3-morpholinecarboxylic acid
    • AKOS015912493
    • Q-103226
    • AKOS015841580
    • SCHEMBL186174
    • MDL： MFCD04114909
    • Inchi： 1S/C10H17NO5/c1-10(2,3)16-9(14)11-4-5-15-6-7(11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)/t7-/m1/s1
    • InChI Key： KVXXEKIGMOEPSA-SSDOTTSWSA-N
    • SMILES： C(N1CCOC[C@@H]1C(=O)O)(=O)OC(C)(C)C

Computed Properties

  • Exact Mass: 231.11100
  • Monoisotopic Mass: 231.111
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 5
  • Heavy Atom Count: 16
  • Rotatable Bond Count: 3
  • Complexity: 283
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 1
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 76.1
  • XLogP3: 0.4

Experimental Properties

  • Color/Form: White to Yellow Solid
  • Density: 1.23
  • Melting Point: 181 °C
  • Boiling Point: 369.5°C at 760 mmHg
  • Flash Point: 177.3℃
  • Refractive Index: 1.492
  • PSA: 76.07000
  • LogP: 0.64480

(3R)-4-[(tert-butoxy)carbonyl]morpholine-3-carboxylic acid Security Information

(3R)-4-[(tert-butoxy)carbonyl]morpholine-3-carboxylic acid Customs Data

  • HS CODE：2934999090
  • Customs Data：

    China Customs Code:

    2934999090

    Overview:

    2934999090. Other heterocyclic compounds. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

(3R)-4-[(tert-butoxy)carbonyl]morpholine-3-carboxylic acid Pricemore >>

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(3R)-4-[(tert-butoxy)carbonyl]morpholine-3-carboxylic acid Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran
2.1 Reagents: Triethylamine Solvents: Methanol ;  0 - 5 °C; 1 h, rt
2.2 Reagents: Water ;  rt
3.1 Reagents: Sodium bicarbonate ,  Tempo ,  Sodium hypochlorite ,  Potassium bromide Solvents: Acetone ,  Water
Reference
Synthesis of chiral C/N-functionalized morpholine alcohols: study of their catalytic ability as ligand in asymmetric diethylzinc addition to aldehyde
Dave, Rajesh; et al, Tetrahedron: Asymmetry, 2006, 17(3), 388-401

Production Method 2

Reaction Conditions
1.1 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ;  0 - 5 °C; 1 h, rt
1.2 Reagents: Triethylamine ,  Diisopropylethylamine Solvents: Methanol ;  4 h, 80 °C
2.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran
3.1 Reagents: Triethylamine Solvents: Methanol ;  0 - 5 °C; 1 h, rt
3.2 Reagents: Water ;  rt
4.1 Reagents: Sodium bicarbonate ,  Tempo ,  Sodium hypochlorite ,  Potassium bromide Solvents: Acetone ,  Water
Reference
Synthesis of chiral C/N-functionalized morpholine alcohols: study of their catalytic ability as ligand in asymmetric diethylzinc addition to aldehyde
Dave, Rajesh; et al, Tetrahedron: Asymmetry, 2006, 17(3), 388-401

Production Method 3

Reaction Conditions
1.1 Reagents: Sodium bicarbonate ,  Tempo ,  Sodium hypochlorite ,  Potassium bromide Solvents: Acetone ,  Water
Reference
Synthesis of chiral C/N-functionalized morpholine alcohols: study of their catalytic ability as ligand in asymmetric diethylzinc addition to aldehyde
Dave, Rajesh; et al, Tetrahedron: Asymmetry, 2006, 17(3), 388-401

Production Method 4

Reaction Conditions
1.1 Reagents: Triethylamine Solvents: Methanol ;  0 - 5 °C; 1 h, rt
1.2 Reagents: Water ;  rt
2.1 Reagents: Sodium bicarbonate ,  Tempo ,  Sodium hypochlorite ,  Potassium bromide Solvents: Acetone ,  Water
Reference
Synthesis of chiral C/N-functionalized morpholine alcohols: study of their catalytic ability as ligand in asymmetric diethylzinc addition to aldehyde
Dave, Rajesh; et al, Tetrahedron: Asymmetry, 2006, 17(3), 388-401

Production Method 5

Reaction Conditions
1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  -30 °C; 2 h, rt
2.1 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ;  0 - 5 °C; 1 h, rt
2.2 Reagents: Triethylamine ,  Diisopropylethylamine Solvents: Methanol ;  4 h, 80 °C
3.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran
4.1 Reagents: Triethylamine Solvents: Methanol ;  0 - 5 °C; 1 h, rt
4.2 Reagents: Water ;  rt
5.1 Reagents: Sodium bicarbonate ,  Tempo ,  Sodium hypochlorite ,  Potassium bromide Solvents: Acetone ,  Water
Reference
Synthesis of chiral C/N-functionalized morpholine alcohols: study of their catalytic ability as ligand in asymmetric diethylzinc addition to aldehyde
Dave, Rajesh; et al, Tetrahedron: Asymmetry, 2006, 17(3), 388-401

Production Method 6

Reaction Conditions
1.1 Reagents: Diisobutylaluminum hydride Solvents: Dichloromethane ,  Toluene ;  1 h, -78 °C; -78 °C → 0 °C; 2 h, 0 °C
1.2 Reagents: Hydrochloric acid Solvents: Methanol ,  Water ;  -78 °C
1.3 Reagents: Lithium borohydride Solvents: Diethyl ether ;  0 - 5 °C; 12 h, rt
1.4 Reagents: Hydrochloric acid Solvents: Water ;  0 - 5 °C
2.1 Reagents: Triethylamine Solvents: Dichloromethane ;  -30 °C; 2 h, rt
3.1 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ;  0 - 5 °C; 1 h, rt
3.2 Reagents: Triethylamine ,  Diisopropylethylamine Solvents: Methanol ;  4 h, 80 °C
4.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran
5.1 Reagents: Triethylamine Solvents: Methanol ;  0 - 5 °C; 1 h, rt
5.2 Reagents: Water ;  rt
6.1 Reagents: Sodium bicarbonate ,  Tempo ,  Sodium hypochlorite ,  Potassium bromide Solvents: Acetone ,  Water
Reference
Synthesis of chiral C/N-functionalized morpholine alcohols: study of their catalytic ability as ligand in asymmetric diethylzinc addition to aldehyde
Dave, Rajesh; et al, Tetrahedron: Asymmetry, 2006, 17(3), 388-401

(3R)-4-[(tert-butoxy)carbonyl]morpholine-3-carboxylic acid Raw materials

(3R)-4-[(tert-butoxy)carbonyl]morpholine-3-carboxylic acid Preparation Products

(3R)-4-[(tert-butoxy)carbonyl]morpholine-3-carboxylic acid Related Literature

Related Categories

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